Positive Paradigm As The Barrier of Art Creativity Interpretation

In the modern era, during the end of 17 century, appears empiric paradigm in the philosophy field. This paradigm emerges due to the critic towards mythical social thought. The next step appears positivism thought by Auguste Comte in 1830, which stated that Sociology based on science analogy that can be learned in the form of empiric data with exact calculation; out of this is rated as not scientific. The education field also trails the modern thought tradition, along with Comte’s positivistic thought. This modern era eventually has been opposed by postmodern philosophers. The frailties in the modern era are criticized by the appearance of the postmodern paradigm. Positivistic thought, in reality, could not reveal study beyond human and society, because this study is strong, and can only reach the ontologic stage, in substance of the object. While this could not be revealed because its level involves human and society’s way of thinking, primordial, tradition, and historical aspects, this study focuses on the weaknesses of positivistic research. Then it will present post-positivistic-postmodern research through Hermeneutika and Foucauldian Genealogy research.

FEATURES OF THE CONTENT AND METHODS OF CONDUCTING CLASS WITH STUDENTS OF THE SPECIAL DEPARTMENT OF THE DISCIPLINE “PHYSICAL CULTURE AND SPORT”

The changing features of the work of the special organization, taking into account the number of students and differences, associated with the frequent diseases, have been revealed. In the course of research, the percentage of students of the Special Department to the total number of students, entered the State University of Management in the 2018/2019 academic year (12.53 %), has been determined. Four vain groups of diseases have been identified: musculoskeletal system, cardiovascular system, vision, and some students with multiple diseases. In the selection of means and methods of training in physical culture, it is necessary to study in more detail the distribution of students with several diseases among university institutes and reveal study groups in the schedule grid, which require a special teaching approach. The results of this study will serve as the basis of the optimizing medical and prophylactic complexes of exercises for students of the State University of Management.

Disease Characteristics of Minority Patient Populations with Polycythemia Vera: An Analysis from the Reveal Study

Introduction: Polycythemia vera (PV) is associated with increased blood cell counts, risk of thrombosis, and symptoms including fatigue and pruritus. Few studies have examined the presence or absence of racial/ethnic disparities among patients with PV. The objective of this analysis is to describe differences in disease characteristics, diagnosis, treatment, and quality of life (QOL) among Caucasian and non-Caucasian patients with PV in the United States enrolled in the prospective, observational REVEAL study. Methods: The ongoing REVEAL study (ClinicalTrials.gov ID, NCT02252159) is a prospective, multicenter, observational study of adult patients with PV in the United States. Patients were observed during a 36-month period, during which clinical data were collected from usual care visits. This analysis compared demographics, disease and clinical characteristics, disease management, comorbidities, and QOL between Caucasian and non-Caucasian patients with PV at enrollment. QOL was measured by the European Organisation for Research and Treatment of Cancer Questionnaire C30 (EORTC QLQ-C30) and Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score (MPN-SAF TSS). Results are summarized with descriptive statistics. Results: Of the 2,510 patients enrolled in REVEAL, 2,237 were Caucasian (89.1%); 199 (7.9%) were non-Caucasian, comprised of African American (5.7%), Asian (1.5%), Native American Indian (0.2%), Pacific Islander (0.1%), and other patients (0.4%); no information was provided regarding race or ethnicity for 74 patients (2.9%). Baseline disease characteristics were similar for Caucasian and non-Caucasian groups with respect to gender and disease duration. There were no differences in method of diagnosis, laboratory values, or overall history of thrombosis between groups (Figure 1A). Mean age was higher among Caucasian patients compared to non-Caucasian patients (66.6 vs 63.8 years, respectively). The proportion of patients from rural areas was higher among Caucasian vs non-Caucasian patients (28.8% vs 12.6%); similarly, the proportion of patients from urban areas was lower among Caucasian vs non-Caucasian patients (23.1% vs 46.7%). The proportion of patients with some college or higher level of education was higher among Caucasian vs non-Caucasian patients (64.1% vs 50.3%). A higher proportion of Caucasian vs non-Caucasian patients were retired (52.0% vs 43.2%); a higher proportion of non-Caucasian patients reported being unable to work or were disabled (3.8% vs 10.1%). More Caucasian patients had high-risk disease (78.0%) compared with non-Caucasian patients (71.4%), and patients with high-risk disease were managed similarly between groups. However, Caucasian patients with low-risk disease received more phlebotomies (56.6%) than non-Caucasian patients with low-risk disease (40.4%), and over twice as many non-Caucasian patients received hydroxyurea (38.6%) than Caucasian patients (15.6%) (Figure 1B). MPN-SAF TSSs were higher for non-Caucasian patients compared with Caucasian patients, suggesting a worse symptom burden. Similarly, non-Caucasian patients reported lower functional and symptom outcomes on the EORTC QLQ-C30, including a disparity in financial difficulties, compared to Caucasian patients (Figure 1C). Conclusions: This analysis evaluated a cohort of racial/ethnic minority patients with PV treated in the United States. As in other cancer-related trials, there is a risk that racial and ethnic minorities may be underrepresented in REVEAL. With this limitation in mind, in this analysis, differences were not observed among Caucasian and non-Caucasian patients with respect to method of diagnosis, duration of disease, thrombosis rates, or management of high-risk disease. Non-Caucasian patients demonstrated higher rates of low-risk disease and cytoreductive therapy for low-risk disease yet had worse symptom burden, lower functional scores, and greater disability. This study underscores the importance of symptom assessment and ancillary resource availability for patients with PV Disclosures Altomare: Bayer: Consultancy; Genentech: Consultancy; Ipsen: Other: Advisory Board Member; Celgene: Other: Advisory Board Member; Incyte: Consultancy; Novartis: Consultancy; Amgen: Consultancy. Colucci:Incyte: Employment, Equity Ownership. Parasuraman:Incyte: Employment, Equity Ownership. Paranagama:Incyte: Employment, Equity Ownership.