Informationisation construction of pharmacology continuing education – a case study on big data analysis of the aetiology of rheumatoid arthritis

The goal of promoting Information and Communication Technology of continuing education in colleges and universities is to standardise the process of teaching and scientific research, make the process more scientific and refined, so as to facilitate and improve the quality of teaching and scientific research, as well as professional disciplines. Rheumatoid arthritis is a disease with chronic, symmetrical and non-specific inflammation of the synovium of the joints (subcutaneous nodules, pericarditis, pleurisy, pneumonia, peripheral neuritis etc.) as the main clinical manifestations. The analysis of pharmacological big data information helps to understand its aetiology and pathological mechanism, which is complex and involves various pathogenic factors.

A CRITICAL REVIEW ON MADHUMEHA JANYA TWAK-GATA VATA WITH SPECIAL REFERENCE TO DIABETIC PERIPHERAL NEURITIS

With the increasing prevalence of Diabetes mellitus especially in the middle age group, the chances of developing neuro-vascular complications are very high. One such complication is Diabetic Peripheral Neuropathy / Distal Symmetric sensory Polyneuropathy (DSPN). Diabetes mellitus can be correlated to Madhumeha and its complication Peripheral neuropathy to that of Twak-gata vata. Twakgata vata is one such vatavyadhi which can manifest in a Madhumeha Rogi. According to Acharya Charaka, Prakupita vata localized in twak brings about dryness of skin, skin cracks open, numbness in that part, emaciation, black discolouration, pricking type of pain, a feeling of stretching in that part, redness, and pain in small joints. Charaka has explained the special reason for the manifestation of a vatavyadhi. He says that depending upon the specific cause and site the aggravated vata produces different types of vyadhis, like twak-gata vata, raktagata vata, etc. Though, Daha as a lakshana has not been mentioned under Twakgata vata lakshanas, when there is anubandha of vata with pitta, daha is seen. Sushruta says in rasa-rakta etc., if vata gets associated with other doshas it produces various disorders. Ex: If there is daha, then association of vata with pitta should be inferred.

Common ocular motor paralysis in a tabetic anatomical examination. A. Papadaki. (Neurological Review, 1904)

Musculi externi eyes are rarely (39: 100) paralyzed in the prodromal period of the tabes. Paralysis is mild and transient at first, but returns severe and prolonged. In this case, all, or almost all, of the motor of the eye is affected, which deviates outward, and ptosis sets in. Temporary paralysis, according to some, are considered to be a consequence of peripheral neuritis, and long-term paralysis is a consequence of damage to the centers of the medulla oblongata. Adamkievitz considered the cause of transient diplopia to be a short-term rush of blood to the nerve trunks and nuclei, and Gweicher - sclerosis of the arteries and ischemia of the motor centers. Dejerine, in a case of isolated paralysis, of a tabetik's eyelid lifter, after opening, found a deep degeneration of his nerve filament, while the trunk of nervi oculomotorii turned out to be unchanged. Because of this, he considers the disease to be peripheral nervo-tabes.

Peripheral neuropathy in Chronic Kidney Diseases: prevalence and its correlates

Background: Peripheral polyneuropathy is most common Chronic Kidney Diseases (CKD) related complication with prevalence of more than 60%. The prevalence of peripheral neuropathy is directly proportional to duration and severity of CKD. Objective of the study was to study and assess the prevalence of peripheral neuritis and its correlates in patients with chronic kidney diseases.Methods: The present study was a cross sectional; descriptive study was conducted in October 2016 to October 2018. Data analysed by using SPSS 23.0 version.Results: Out of 90 subjects, majority were from 45-54 years age group (26). 70% were male and 30% were females. Out of 60 pre-HD patients, 33(55%) showed peripheral neuropathy. Out of 30 HD patients, 24(80%) showed peripheral neuropathy. Maximum percentage of PN seen in 45-54 age group (76.92%) amongst the 60 males 39 (65%) and amongst 30 females 18(60%) showed peripheral neuropathy. Maximum percentage of PN seen in >5 years age group (79.31%). Pure axonal sensory motor neuropathy (28.88%) was most common pattern.Conclusions: Peripheral neuropathy is very common in CKD, more common in dialysis patients as compared to predialysis patients.