Quantitatively monitoring polymer chain growth and topology formation based on monodisperse polymers

In this work, a novel technique for monitoring polymer chain growth and topology formation was demonstrated by precision synthesis of monodisperse polymers, which opened a novel avenue for obtaining real-time polymer structure information.

Dendrimers: The Novel Pharmaceutical Drug Carriers

Dendrimers represent a novel class of structurally controlled macromolecules derived from a branches-upon-branches structural motif. These consist of well defined, highly branched moieties that radiate from a central core and are synthesized through a stepwise, repetitive reaction sequence that guarantees complete shells for each generation, leading to formation of monodisperse polymers. The synthetic procedures developed for dendrimer preparation permit nearly complete control over the critical molecular design parameters, such as size, shape, surface/interior chemistry, flexibility, and topology by virtue of which these macromolecules offer diverse applications in drug delivery, solubility enhancement, gene therapy and diagnostic field. This article provides an insight into the structure, synthesis, properties, types and the applications of dendrimers in the bio-medical field.