The design and sensitivity of JUNO’s scintillator radiopurity pre-detector OSIRIS

The OSIRIS detector is a subsystem of the liquid scintillator filling chain of the JUNO reactor neutrino experiment. Its purpose is to validate the radiopurity of the scintillator to assure that all components of the JUNO scintillator system work to specifications and only neutrino-grade scintillator is filled into the JUNO Central Detector. The aspired sensitivity level of $$10^{-16}\hbox { g/g}$$ 10 - 16 g/g of $$^{238}\hbox {U}$$ 238 U and $$^{232}\hbox {Th}$$ 232 Th requires a large ($$\sim 20\,\hbox {m}^3$$ ∼ 20 m 3 ) detection volume and ultralow background levels. The present paper reports on the design and major components of the OSIRIS detector, the detector simulation as well as the measuring strategies foreseen and the sensitivity levels to U/Th that can be reached in this setup.

Implantable NMR Microcoils in Rats: A New Tool for Exploring Tumor Metabolism at Sub-Microliter Scale?

The aim of this study was to evaluate the potential of a miniaturized implantable nuclear magnetic resonance (NMR) coil to acquire in vivo proton NMR spectra in sub-microliter regions of interest and to obtain metabolic information using magnetic resonance spectroscopy (MRS) in these small volumes. For this purpose, the NMR microcoils were implanted in the right cortex of healthy rats and in C6 glioma-bearing rats. The dimensions of the microcoil were 450 micrometers wide and 3 mm long. The MRS acquisitions were performed at 7 Tesla using volume coil for RF excitation and microcoil for signal reception. The detection volume of the microcoil was measured equal to 450 nL. A gain in sensitivity equal to 76 was found in favor of implanted microcoil as compared to external surface coil. Nine resonances from metabolites were assigned in the spectra acquired in healthy rats (n = 5) and in glioma-bearing rat (n = 1). The differences in relative amplitude of choline, lactate and creatine resonances observed in glioma-bearing animal were in agreement with published findings on this tumor model. In conclusion, the designed implantable microcoil is suitable for in vivo MRS and can be used for probing the metabolism in localized and very small regions of interest in a tumor.

Detecting plastic items in the water column using an Acoustic Doppler Current Profiler (ADCP)

<p>An Acoustic Doppler Current Profiler (ADCP) is commonly used to monitor flow velocity. An accurate method to obtain discharge in a river or a channel is to mount an ADCP to a boat and sail transects across the channel. Additionally, these surveys may also be used to obtain the amount of plastic items in the water column. The transport of plastic items suspended in the water column may be substantial and is more challenging to monitor than the transport of floating items. We carried out a feasibility test in a harbour of a river. We deployed the ADCP horizontally at 1.0 m depth and released plastic items (and similarly shaped organic items for comparison) 5 times at 1.0, 3.0 and 5.0 m from the ADCP. We compared the signal strength in a 5 s period after release with the background signal strength.</p><p>The item was steady within the detection volume for the majority of the 5 s periods. Three out of five plastic items had signal strengths a least 5 dB higher than the background strength (at several distances). We conclude that at least these items were detected. The similarly shaped organic items generally had a lower signal strength. Although the response of each item as a function of orientation, distance along and across the beam should be investigated further, the feasibility study shows the potential to additionally determine the amount of plastic items in the water column from ADCP observations.  </p>

Sterile neutrino oscillometry with Jinping

The existence of sterile neutrino is an open question in neutrino physics up to now. The method of neutrino oscillometry provides a powerful tool to test the common 3 + 1 sterile neutrino hypothesis, i.e. three active flavors and one sterile flavor. There are several antineutrino sources which can be used for this method. One of them is the well known isotope chain of $$^{144}\mathrm{Ce}$$144Ce–$$^{144}{\mathrm{Pr}}$$144Pr with initial activity around 50–100 kCi. It has compact size and might be installed either outside or inside the detector. Another one is the short-lived isotope $$^8{\mathrm{Li}}$$8Li, which can be produced in nuclear reaction of a proton beam hitting a beryllium target. The lithium source has only the out-of-detector option due to its large size. The proposed Jinping water-based liquid scintillator detector will be used as a detection volume. Above experimental setups will allow us to cover the current best fit values of oscillation parameters with 90% C.L. At the same time, it is sensitive to the region of the Neutrino-4 result.

Abstract TP90: Advance: Automated Detection and Volumetric Assessment of Intracerebral Hemorrhage

Introduction: Intracerebral hemorrhages (ICHs) accounts for approximately 15% of all strokes but carry high rates of morbidity and mortality. The location and volume of hematoma are strongly associated with outcomes. As novel treatments become established, early detection and proper volume measurement are becoming increasingly important. We aim to evaluate an artificial intelligence-based algorithm (Viz-ICH® v1.4) for ICH detection, volume measurement, and its differentiation from intraventricular hemorrhage (IVH). Methods: We performed single center retrospective analysis of non-contrast CTs (NCCTs), randomly picked from prospective cohort of acute stroke patients, with and without parenchymal ICHs, admitted to our stroke center from 02/14-03/17. Experienced stroke neurologists graded NCCTs with a semi-automated tool (OsiriX MD v.9.0.1) for presence and volume of ICH, and also presence of intraventricular hemorrhage (IVH). AI- and human-based readings were compared. Results: A total of 211 NCCTs were evaluated including 163 ICHs and 48 controls. The ICH location was basal ganglionic in 55.8%, Lobar in 23.3% and posterior fossa in 12% of the cases and 51.5 % of patients had associated IVH with mean volume 41.94 cc. The AI algorithm demonstrated high accuracy for ICH detection and volumetric measurement (Table). The maximal running time of the algorithm was under 15s. Conclusion: The presence and volume of ICHs can be accurately detected by AI Viz-ICH Algorithm, with good differentiation from IVH which will help in early triage of these patients.