Going Bone Deep: Osseous Rosai–Dorfman Disease in an Adult with Recurrent, Culture-Negative Osteomyelitis

A patient presented for medical care on three separate occasions over the course of two years with recurrent right knee pain attributed to chronic osteomyelitis. Careful assessment revealed that his symptoms were caused by osseous Rosai–Dorfman disease. This case presents an alternative diagnostic possibility for culture-negative chronic osteomyelitis.

Nuevos casos de feocromocitoma en el hospital universitario de Neiva

El feocromocitoma es un tumor productor de catecolaminas con una prevalencia de 2 a 8 por millón de personas, que deriva en 85% de los casos de las células cromafines de la médula suprarrenal. La presente revisión, ilustrada con una serie de casos, brinda una actualización del tema que muestra situaciones de la vida real que ocurren en nuestra institución. Las dificultades para el estudio y diagnóstico, por la pobre disponibilidad de las pruebas para determinar el exceso de catecolaminas o sus metabolitos y lo infrecuente de la condición, pueden retardar la sospecha de esta patología como una posibilidad diagnóstica y diferir la interconsulta a endocrinología, necesaria para aportar en el tratamiento de los casos de feocromocitoma. Con este documento describimos lo que ocurre en nuestra población y realizamos una revisión práctica del estudio, diagnóstico y manejo actual de este tipo de tumores.Abstract Pheochromocytoma is a catecholamine producing tumor with a prevalence of 2 to 8 per million people, 85% arise from chromaffin cells of the adrenal medulla. The present review, illustrated with a case series, gives an update on the issue showing real life situations that occur in our institution. The difficulties in the study and diagnosis by the poor availability of tests for excess catecholamines or their metabolites and uncommon condition, can slow the suspicion of this disease as a diagnostic possibility and defer interconsultation to endocrinology, necessary for contribute to treat pheochromocytoma cases. In this paper we describe what happens in our community and realize a practical review in the study, diagnosis and current management of these tumors.

Renal cell carcinoma with secondary hemophagocytic syndrome:A case report

A patient with a suspected malignancy and pancytopenia warrants much consideration. Most clinicians would consider bone marrow infiltrative process, heralding a grave prognosis. However, rare occurrence of hemophagocytic lymphohistiocytosis is another diagnostic possibility we should keep in mind. The treatment choices and overall prognosis may differ from patients without hemophagocytosis. We present a case of incidentally found advanced renal cell carcinoma (RCC) concurrent with hemophagocytosis process in the bone marrow. We also discuss the importance of this finding.