Thermal transport properties of graphite carbon nitride

Graphite carbon nitride (GCN), which can be regarded as a nitrogen heteroatom-substituted graphite framework, has attracted great attention as a new 2D layered structure material with semiconductor electronic characteristics.

Hetero-Tricyclic Lead Scaffold as Novel PDE5A Inhibitor for Antihypertensive Activity: In Silico Docking Studies

Objective:To screen the phytochemicals for phosphodiesterase 5A (PDE5A) inhibitory potential and identify lead scaffolds of antihypertensive phytochemicals using in silico docking studies.Methods:In this perspective, reported 269 antihypertensive phytochemicals were selected. Sildenafil, a PDE5A inhibitor was used as the standard. In silico docking study was carried out to screen and identify the inhibiting potential of the selected phytochemicals against PDE5A enzyme using vLife MDS 4.4 software.Results:Based on docking score, π-stacking, H-bond and ionic interactions, 237 out of 269 molecules were selected which have shown one or more interactions. Protein residue Gln817A was involved in H-boding whereas Val782A, Phe820A and Leu804A were involved in π-stacking interaction with ligand. The selected 237 phytochemicals were structurally diverse, therefore 82 out of 237 molecules with one or more tricycles were filtered out for further analysis. Amongst tricyclic molecules, 14 molecules containing nitrogen heteroatom were selected for lead scaffold identification which finally resulted in three different basic chemical backbones like pyridoindole, tetrahydro-pyridonaphthyridine and dihydro-pyridoquinazoline as lead scaffolds.Conclusion:In silico docking studies revealed that nitrogen-containing tetrahydro-pyridonaphthyridine and dihydro-pyridoquinazoline tricyclic lead scaffolds have emerged as novel PDE5A inhibitors for antihypertensive activity. The identified lead scaffolds may provide antihypertensive lead molecules after its optimization.

Synthesis of Five-Membered Heterocycles Containing Nitrogen Heteroatom Under Ultrasonic Irradiation

Ultrasonic irradiation is employed to accelerate organic reactions. Under sonication reduced time, good selectivity, excellent yield, and milder conditions were observed for many organic reactions. Ultrasonic reactions are increasingly used as green, clean, and environment-friendly methods in organic synthesis in terms of energy conservation and waste minimization. The use of ultrasound irradiation is increasing in coming years. The use of ultrasound irradiation in the synthesis of five-membered N-heterocycles is depicted in the present review article.

Interesting Mechanistic Approach for Nitrogen Heterocycles of Industrial Importance

Nitrogen heterocycles have played an important role in different industrial sectors.Porphyrins the macrocyclic compounds containing pyrrole rings provide an extremely versatile platform with desired peripheral functionality and metal complexes to form the self assembly under varying reaction conditions. Haemoglobin an iron complex is responsible for binding molecular oxygen and transporting it to different sites. Mechanistically interesting N-heterocycles, Arylidene-1,3-indandione adducts (6) and (7) synthesized frequently are of immense pharmaceutical importance showing fungicidal and bactericidal activities. Nitrogen heteroatom phthalimide derivatives(8),(9) and (10) have been evaluated as possible potential prodrugs. A wide range of Nitrogen heterocycles have been synthesized for every imaginable use in dye and polymer industries.

Influence of N-heteroaromatic π–π stacking on supramolecular assembly and coordination geometry; effect of a single-atom change in the ligand

A study on how the polarization of aromatic systems, through the introduction of a nitrogen heteroatom, affects the π–π interactions and crystal packing of mercury coordination compounds.