Seasonal Surface Fluctuation of a Slow-Moving Landslide Detected by Multitemporal Interferometry (MTI) on the Huafan University Campus, Northern Taiwan

A slow-moving landslide on the Huafan University campus, which is located on a dip slope in northern Taiwan, has been observed since 1990. However, reliable monitoring data are difficult to acquire after 2018 due to the lack of continuous maintenance of the field measurement equipment. In this study, the multitemporal interferometry (MTI) technique is applied with Sentinel-1 SAR images to monitor the slow-moving landslide from 2014–2019. The slow-moving areas detected by persistent scatterer (PS) pixels are consistent with the range of previous studies, which are based on in situ monitoring data and field surveys. According to the time series of the PS pixels, a long period gravity-induced deformation of the slow-moving landslide can be clearly observed. Moreover, a short period seasonal surface fluctuation of the slow-moving landslide, which has seldom been discussed before, can also be detected in this study. The seasonal surface fluctuation is in-phase with precipitation, which is inferred to be related to the geological and hydrological conditions of the study area. The MTI technique can compensate for the lack of surface displacement data, in this case, the Huafan University campus, and provide information for evaluating and monitoring slow-moving landslides for possible landslide early warning in the future.

Cell surface fluctuations regulate early embryonic lineage sorting

In development, lineage segregation of multiple lineages must be coordinated in time and space. An important example is the mammalian inner cell mass (ICM), in which the primitive endoderm (PrE, founder of the yolk sac) physically segregates from the epiblast (EPI, founder of the foetus). The physical mechanisms that determine this spatial segregation between EPI and PrE are still poorly understood. Here, we identify an asymmetry in cell-cell affinity, a mechanical property thought to play a significant role in tissue sorting in other systems, between EPI and PrE precursors (pEPI and pPrE). However, a computational model of cell sorting indicated that these differences alone appeared insufficient to explain the spatial segregation. We also observed significantly greater surface fluctuations in pPrE compared to pEPI. Including the enhanced surface fluctuation in pPrE in our simulation led to robust cell sorting. We identify phospho-ERM regulated membrane tension as an important mediator of the increased surface fluctuations in pPrE. Using aggregates of engineered cell lines with different surface fluctuation levels cells with higher surface fluctuations were consistently excluded to the outside of the aggregate. These cells behaved similarly when incorporated in the embryo. Surface fluctuations-driven segregation is reminiscent of activity-induced phase separation, a sorting phenomenon in colloidal physics. Together, our experiments and model identify dynamic cell surface fluctuations, in addition to static mechanical properties, as a key factor for orchestrating the correct spatial positioning of the founder embryonic lineages.