behavioral phase
Recently Published Documents


TOTAL DOCUMENTS

23
(FIVE YEARS 6)

H-INDEX

12
(FIVE YEARS 0)

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Amicia D Elliott ◽  
Adama Berndt ◽  
Matthew Houpert ◽  
Snehashis Roy ◽  
Robert L Scott ◽  
...  

Identifying neural substrates of behavior requires defining actions in terms that map onto brain activity. Brain and muscle activity naturally correlate via the output of motor neurons, but apart from simple movements it has been difficult to define behavior in terms of muscle contractions. By mapping the musculature of the pupal fruit fly and comprehensively imaging muscle activation at single cell resolution, we here describe a multiphasic behavioral sequence in Drosophila. Our characterization identifies a previously undescribed behavioral phase and permits extraction of major movements by a convolutional neural network. We deconstruct movements into a syllabary of co-active muscles and identify specific syllables that are sensitive to neuromodulatory manipulations. We find that muscle activity shows considerable variability, with sequential increases in stereotypy dependent upon neuromodulation. Our work provides a platform for studying whole-animal behavior, quantifying its variability across multiple spatiotemporal scales, and analyzing its neuromodulatory regulation at cellular resolution.



2021 ◽  
Author(s):  
Amicia D. Elliott ◽  
Adama Berndt ◽  
Matthew Houpert ◽  
Snehashis Roy ◽  
Robert L. Scott ◽  
...  

SummaryIdentifying neural substrates of behavior requires defining actions in terms that map onto brain activity. Brain and muscle activity naturally correlate via the output of motor neurons, but apart from simple movements it has been difficult to define behavior in terms of muscle contractions. By mapping the musculature of the pupal fruit fly and comprehensively imaging muscle activation at single cell resolution, we here describe a multiphasic behavioral sequence in Drosophila. Our characterization identifies a previously undescribed behavioral phase and permits extraction of major movements by a convolutional neural network. We deconstruct movements into a syllabary of co-active muscles and identify specific syllables that are sensitive to neuromodulatory manipulations. We find that muscle activity shows considerable variability, which reduces upon neuromodulation. Our work provides a platform for studying whole-animal behavior, quantifying its variability across multiple spatiotemporal scales, and analyzing its neuromodulatory regulation at cellular resolution.



2021 ◽  
Vol 2 (1) ◽  
pp. 100285
Author(s):  
Boyan Kostadinov ◽  
Hannah Lee Pettibone ◽  
Evardra Valerie Bell ◽  
Xiaona Zhou ◽  
Ausra Pranevicius ◽  
...  


2020 ◽  
Vol 35 (6) ◽  
pp. 576-587
Author(s):  
Phan Q. Duy ◽  
Ruchi Komal ◽  
Melissa E. S. Richardson ◽  
Katie S. Hahm ◽  
Diego C. Fernandez ◽  
...  

To be physiologically relevant, the period of the central circadian pacemaker, located in the suprachiasmatic nucleus (SCN), has to match the solar day in a process known as circadian photoentrainment. However, little is known about the spatiotemporal molecular changes that occur in the SCN in response to light. In this study, we sought to systematically characterize the circadian and light effects on activity-dependent markers of transcriptional (cFos), translational (pS6), and epigenetic (pH3) activities in the mouse SCN. To investigate circadian versus light influences on these molecular responses, we harvested brains from adult wild-type mice in darkness at different circadian times (CT) or from mice exposed to a 15-min light pulse at the middle of the subjective day (CT6, no phase shifts), early subjective night (CT14, large phase delays), or late subjective night (CT22, small phase advances). We found that cFos and pS6 exhibited rhythmic circadian expression in the SCN with distinct spatial rhythms, whereas pH3 expression was undetectable at all circadian phases. cFos rhythms were largely limited to the SCN shell, whereas pS6 rhythms encompassed the entire SCN. pH3, pS6, and cFos showed gating in response to light; however, we were surprised to find that the expression levels of these markers were not higher at phases when larger phase shifts are observed behaviorally (CT14 versus CT22). We then used animals lacking melanopsin (melanopsin knockout [MKO]), which show deficits in phase delays, to further investigate whether changes in these molecular markers correspond to behavioral phase shifts. Surprisingly, only pS6 showed deficits in MKOs at CT14. Therefore, our previous understanding of the molecular pathways that lead to circadian photoentrainment needs to be revised.



2020 ◽  
Vol 7 (2) ◽  
pp. 25-33
Author(s):  
Bernardo Urbani ◽  
Dionisios Youlatos ◽  
Martín M. Kowalewski

Abstract. Sleep is the longest and most continuous behavioral phase in the 24 h cycle of mammals. However, selection of postures, substrates, and tree parts during sleep has not been adequately explored, as well as their evolutionary consequences. The present study investigates postural behavior, substrate, and tree part use during sleep in three howler species (A. palliata, A. macconnelli, and A. caraya) in Nicaragua, French Guiana, and Argentina. All three species were consistent in the use of a crouched ball-like sit-in posture on large, horizontal, unramified, or bifurcated substrates, and in avoiding the periphery of tree crowns. The regularities of these sleeping patterns are very likely functionally associated with protection from potential predators and extreme weather conditions, biomechanical stability, thermoregulation, and enhancement of the digestive process of hard-to-decompose plant material.



2020 ◽  
Vol 121 ◽  
pp. 103374
Author(s):  
Li Hou ◽  
Xuesong Wang ◽  
Pengcheng Yang ◽  
Beibei Li ◽  
Zhe Lin ◽  
...  


2012 ◽  
Vol 8 (8) ◽  
pp. e1002642 ◽  
Author(s):  
Chad M. Topaz ◽  
Maria R. D'Orsogna ◽  
Leah Edelstein-Keshet ◽  
Andrew J. Bernoff


Author(s):  
N. Beckers ◽  
D. Pool ◽  
A.R. Valente Pais ◽  
M.M. van Paassen ◽  
M. Mulder


Author(s):  
P. Maffezzoni ◽  
S. Levantino ◽  
C. Samori ◽  
A. L. Lacaita ◽  
D. D'Amore ◽  
...  


Sign in / Sign up

Export Citation Format

Share Document