Radiomics Analysis Based on CT’s greater-omental caking for Predicting Pathological Grading of Pseudomyxoma Peritonei

Purpose: The objective of this study was to predict the preoperative pathological grading and survival period of Pseudomyxoma peritonei (PMP) by establishing models, including a radiomics model with greater mental caking as the imaging observation index, a clinical model including clinical indexes, and a combination model of these two.Methods: A total of 88 PMP patients were selected. Clinical data of patients, including age, sex, preoperative serum tumor markers [CEA, CA125, and CA199], survival time, and preoperative computed tomography (CT) images were analyzed. Three models (clinical model, radiomics model and joint model) were used to predict PMP pathological grading. The models’ diagnostic efficiency was compared and analyzed by building the receiver operating characteristic (ROC) curve. Simultaneously, the impact of PMP’s different pathological grades was evaluated.Results: The results showed that the radiomics model based on the CT’s greater omental caking, an area under the ROC curve ([AUC] = 0.878), and the combined model (AUC = 0.899) had diagnostic power n for determining PMP pathological grade.Conclusion: The imaging radiomics model based on CT greater omental caking can be used to predict PMP pathological grade, which is important in the treatment selection method and prognosis assessment.

Temporal Evolutions of N2+ Meinel (1,2) Band Near 1.5 μm Associated with Aurora Breakup and their Effects on Mesopause Temperature Estimations from OH Meinel (3,1) Band

We have carried out ground-based NIRAS (Near-InfraRed Aurora and airglow Spectrograph) observations at Syowa station, Antarctic (69.0°S, 39.6°E) and Kiruna (67.8°N, 20.4°E), Sweden for continuous measurements of hydroxyl (OH) rotational temperatures and a precise evaluation of aurora contaminations to OH Meinel (3,1) band. A total of 368-nights observations succeeded for two winter seasons, and three cases in which N+2 Meinel (1,2) band around 1.5 μm was significant were identified. Focusing on two specific cases, detailed spectral characteristics with high temporal resolutions of 30 seconds are presented. Intensities of N+2 band were estimated to be 228 kR and 217 kR just at the moment of the aurora breakup and arc intensifications during pseudo breakup, respectively. At a wavelength of P1(2) line (∼ 1523 nm), N+2 emissions were almost equal to or greater than the OH line intensity. On the other hand, at a wavelength of P1(4) line (∼ 1542 nm), the OH line was not seriously contaminated and still dominant to N+2 emissions. Furthermore, we evaluated N+2 (1,2) band effects on OH rotational temperature estimations quantitatively for the first time. Aurora contaminations from N+2 (1,2) band basically lead negative bias in OH rotational temperature estimated by line-pair-ratio method with P1(2) and P1(4) lines in OH (3,1) band. They possibly cause underestimations of OH rotational temperatures up to 40 K. In addition, N+2 (1,2) band contaminations were temporally limited to a moment around aurora breakup. This is consistent with proceeding studies reporting that enhancements of N+2 (1,2) band were observed associated with International Brightness Coefficient 2-3 auroras. It is also suggested that the contaminations would be neglected in polar cap and sub-aurora zone, where strong aurora intensifications are less observed. Further spectroscopic investigations at this wavelength are needed especially for more precise evaluations of to N+2 (1,2) band contaminations. For example, simultaneous 2-D imaging observation and spectroscopic measurement with high spectral resolutions for airglow in OH (3,1) band will make great advances in more robust temperature estimations.

Calcific Myonecrosis of the Leg: A Rare Entity

Calcific myonecrosis is a rare disease that has been shown to be a late sequela of trauma. This article presents a 68-year-old man with calcific myonecrosis of the leg 40 years after a tibial fracture complicated with peroneal nerve palsy. The soft tissue mass increased in size after another injury to the leg that occurred two years before his presentation. Physical examination at presentation showed a palpable extra-osseous mass at the anterior aspect of the left leg; the mass was not adherent to adjacent soft-tissues and bone, and it was painless but tender to palpation. Radiographs of the left leg showed extensive calcification at the soft-tissue of the anterior and posterior leg. An ultrasonography-guided trocar biopsy was done; histological findings were indicative of calcific myonecrosis. Given the benign entity of the lesion and known high rate of complications, he was recommended for no further treatment except for clinical and imaging observation. Located at the site of the biopsy, he experienced infection with drainage that eventually healed after six months with antibiotics and wound dressing changes. During the last follow-up examination, two years after diagnosis, the patient was asymptomatic without progression of the mass.

Triaging Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ on Percutaneous Core Biopsy to Surgery or Observation: Assiduous Radiologic-Pathologic Correlation Works, Quantitating Extent of Disease Does Not

Context.— The management of lobular neoplasia (LN) found on core biopsy is controversial and ranges from obligatory surgical excision to clinical/imaging observation. Objective.— To determine if in cases of core needle biopsy yielding LN, quantification of normal and diseased terminal ductal lobular units (TDLUs) can predict which cases require surgical excision and which can be safely followed. A secondary goal is to assess whether the concordance or discordance of core biopsy results, determined by rigorous radiologic-pathologic correlation, can predict for upgrade to malignancy at excision. Design.— In this retrospective study, 79 specimens from 78 women who underwent image-guided core needle biopsies between 2005 and 2012 yielding LN were evaluated for total number of TDLUs and total number and percentage of TDLUs involved by LN. Additionally, radiologic-pathologic correlation was performed to assess concordance or discordance. All were correlated with the results of surgical excisional biopsy or imaging/clinical follow-up. Results.— There were 5 upgrades to malignancy. There was no association between upgrade to malignancy and any of the 3 TDLU variables evaluated, including total TDLUs in the specimen (P = .42), total abnormal TDLUs (P = .56), and percent of TDLUs that are abnormal (P = .07). Kendall rank correlation demonstrated a correlation between discordance and upgrade to cancer at surgery that was statistically significant (τb = −0.394, P < .001). Conclusions.— Quantifying total TDLU and those involved by LN on core biopsy will not aid in triaging patients to surgery or observation. Assiduous radiologic-pathologic correlation to determine lesion concordance/discordance can predict those patients who would benefit from surgical excision.