Taurodontism in dental genetics

Taurodontism is a dental anomaly defined by enlargement of the pulp chamber of multirooted teeth with apical displacement of the pulp floor and bifurcation of the roots. Taurodontism can be an isolated trait or part of a syndrome. A study was conducted to document the dental and craniofacial aspects of genetic thin bone disorders in South Africa. Sixty-four individuals with Osteogenesis imperfecta (OI), one individual with Pyle disease and one with Torg-Winchester syndrome respectively, were assessed clinically, radiographically and at a molecular level. Ten patients with OI XI and those with Pyle disease and Torg-Winchester syndrome had taurodontism. Taurodontism has been identified in several genetic disorders necessitating cognizance of the possible existence and implications of this characteristic when managing patients in the dental environment. Further studies should be directed toward identifying the incidence, etiology, and molecular pathways leading to taurodontism and its relationship to genetic syndromes.

Clinical and genetic characteristics and orthopedic manifestations of the Saul–Wilson syndrome in two Russian patients

Background. SaulWilson syndrome (SWS, microcephalic osteodysplastic dysplasia) is a rare genetic variant of skeletal dysplasia and is determined based on the modern classification for thin bone dysplasias. To date, 16 patients with SWS from different countries have been identified. Clinical cases. We presented the first description of the clinical and genetic characteristics of two Russian patients with SWS and compared them with published data. The main clinical manifestations of SWS are characterized by a combination of nanism and pathology of long tubular bones, spine, and eyes. Changes in the phenotype of patients in different age groups were analyzed. Discussion. In the analysis of the clinical manifestations of the observed patients and patients described in the literature, typical dysmorphic features of the face and radiographic data help in the diagnosis of SWS upon clinical examination. In the majority of the described patients, the nucleotide substitution c.1546GA is the major mutation in the gene responsible for SWS, which leads to the replacement of the amino acid Gly516Arg in the protein molecule. Conclusion. Based on the identified specific features of the phenotype of patients with SWS and the presence of a major mutation in the COG4 gene, a priority analysis of gene mutations is necessary. Orthopedic manifestations of SWS can lead to life-threatening conditions (cervical spine instability) and motor limitations (progressive osteoarthritis) and thus should be monitored dynamically.

Shaping of comminuted midface fractures with stock Titanium mesh: a technical note

Multiply fragmented fractures of the maxillofacial region are difficult to fix with traditional miniplate osteosynthesis because of the extremely small size of fragments, complex three-dimensional anatomy, thin bone unable to hold screws and multidirectional pull of muscles. We intend to present a technical note on a case series of extremely comminuted midfacial fractures reconstructed with stock Titanium mesh, cut to shape and used to mold the small fragmented segments into the shape of the facial bones. Severe fragmentation of midface leads to facial hollowing, tissue prolapse and asymmetry even after major facial buttresses are fixed and reconstructed. Simple stock Titanium mesh can be used to reconstruct these severe fragmentations of thin bones of the midface as shown in the series and avoid late and unsightly complications.

Placement of leads for stereotactic electroencephalography without the use of anchor bolts: technical note

OBJECTIVEStereotactic electroencephalography (SEEG) is an increasingly common technique that neurosurgeons use to help identify the epileptogenic zone. The anchor bolt, which typically secures the electrode to the skull, can be problematic in very thin bone or in electrodes placed in the occiput.METHODSA technique is described to place electrodes without the use of an anchor bolt. Accuracy data for entry point, target point, and depth were collected and compared between electrodes placed with and those placed without an anchor bolt.RESULTSA total of 58 patients underwent placement of 793 electrodes, of which 25 were boltless. The mean entry and depth errors at target were equivalent, although there was a trend toward greater depth error with boltless electrodes (3.4 mm vs 2.01 mm and 2.59 mm in the bolted groups, respectively). The mean lateral target error was slightly but significantly smaller for boltless electrodes. The majority (60%) of boltless leads were placed into thin temporal squamous bone. The average skull thickness at the entry point for all boltless leads was 1.85 mm.CONCLUSIONSBoltless SEEG electrodes can be placed through thin bone, adjacent to a cranial defect, or in the occiput with equivalent accuracy to electrodes placed with anchor bolts.

The Effect of Zirconia Material for Dental Implant To Osseointegrated Process

Objective: Tooth lost is the one of mostly case in dentistry. Dental implant are the proper and fast procedure to rehabilitated full or partial edentulous ridge. Many research and clinical study said that the successful of dental implant application are depend on osseointegration which considered by anatomical of the bone structure with implant or mechanical feature of implant. Dissucion : The composition of material and topographic surface are the important thing in osseointegration process . For many patient, Titanium give a good results, but some of patient worried because it can make a grey line in sub gingival or across the ridge which have a thin bone and soft gingival structure, So with zirconia implant hopefully that grey line doesn’t appear. Both of titanium and zirconia are very strong, Titanium have a high flexibility and fracture resistence but, zirconia have a low elasticity, which can cause a micro fracture. Conclusion : Zirconia implant have a good esthetics and looked naturally.

Osseous malformation in calves and its relationship with ingestion of apple pomace in pregnant cows

ABSTRACT: Three outbreaks of osseous malformation in claves born of cows fed apple pomace throughout pregnancy are described. This study was carried out from historical surveys on properties where apple pomace was used in cattle feeding. The outbreaks occurred in the municipalities of Lages, Santa Catarina state, from 2007 to 2012, and Ipê, Rio Grande do Sul state, from 2011 to 2012. These calves presented bone deformity characterized mainly by arthrogryposis and chondrodysplasia of the anterior limbs. At necropsy, the observed changes were restricted to bending and thickening of the anterior limbs and skull. Microscopically, a disorganized, irregular, misaligned hypertrophic zone was observed in the humeral-radio-ulnar joints, in addition to absence of growth zone, thin bone trabeculae, and closed epiphyseal growth plate.