The Impact of Resampling and Denoising Deep Learning Algorithms on Radiomics in Brain Metastases MRI

Background: Magnetic resonance imaging (MRI) is predominant in the therapeutic management of cancer patients, unfortunately, patients have to wait a long time to get an appointment for examination. Therefore, new MRI devices include deep-learning (DL) solutions to save acquisition time. However, the impact of these algorithms on intensity and texture parameters has been poorly studied. The aim of this study was to evaluate the impact of resampling and denoising DL models on radiomics. Methods: Resampling and denoising DL model was developed on 14,243 T1 brain images from 1.5T-MRI. Radiomics were extracted from 40 brain metastases from 11 patients (2049 images). A total of 104 texture features of DL images were compared to original images with paired t-test, Pearson correlation and concordance-correlation-coefficient (CCC). Results: When two times shorter image acquisition shows strong disparities with the originals concerning the radiomics, with significant differences and loss of correlation of 79.81% and 48.08%, respectively. Interestingly, DL models restore textures with 46.15% of unstable parameters and 25.96% of low CCC and without difference for the first-order intensity parameters. Conclusions: Resampling and denoising DL models reconstruct low resolution and noised MRI images acquired quickly into high quality images. While fast MRI acquisition loses most of the radiomic features, DL models restore these parameters.

Which GAN? A comparative study of generative adversarial network-based fast MRI reconstruction

Fast magnetic resonance imaging (MRI) is crucial for clinical applications that can alleviate motion artefacts and increase patient throughput. K -space undersampling is an obvious approach to accelerate MR acquisition. However, undersampling of k -space data can result in blurring and aliasing artefacts for the reconstructed images. Recently, several studies have been proposed to use deep learning-based data-driven models for MRI reconstruction and have obtained promising results. However, the comparison of these methods remains limited because the models have not been trained on the same datasets and the validation strategies may be different. The purpose of this work is to conduct a comparative study to investigate the generative adversarial network (GAN)-based models for MRI reconstruction. We reimplemented and benchmarked four widely used GAN-based architectures including DAGAN, ReconGAN, RefineGAN and KIGAN. These four frameworks were trained and tested on brain, knee and liver MRI images using twofold, fourfold and sixfold accelerations, respectively, with a random undersampling mask. Both quantitative evaluations and qualitative visualization have shown that the RefineGAN method has achieved superior performance in reconstruction with better accuracy and perceptual quality compared to other GAN-based methods. This article is part of the theme issue ‘Synergistic tomographic image reconstruction: part 1’.