Research on Multiple Spectral Ranges with Deep Learning for SpO2 Measurement

Oxyhemoglobin saturation by pulse oximetry (SpO2) has always played an important role in the diagnosis of symptoms. Considering that the traditional SpO2 measurement has a certain error due to the number of wavelengths and the algorithm and the wider application of machine learning and spectrum combination, we propose to use 12-wavelength spectral absorption measurement to improve the accuracy of SpO2 measurement. To investigate the multiple spectral regions for deep learning for SpO2 measurement, three datasets for training and verification were built, which were constructed over the spectra of first region, second region, and full region and their sub-regions, respectively. For each region under the procedures of optimization of our model, a thorough of investigation of hyperparameters is proceeded. Additionally, data augmentation is preformed to expand dataset with added noise randomly, increasing the diversity of data and improving the generalization of the neural network. After that, the established dataset is input to a one dimensional convolution neural network (1D-CNN) to obtain a measurement model of SpO2. In order to enhance the model accuracy, GridSearchCV and Bayesian optimization are applied to optimize the hyperparameters. The optimal accuracies of proposed model optimized by GridSearchCV and Bayesian Optimization is 89.3% and 99.4%, respectively, and trained with the dataset at the spectral region of six wavelengths including 650 nm, 680 nm, 730 nm, 760 nm, 810 nm, 860 nm. The total relative error of the best model is only 0.46%, optimized by Bayesian optimization. Although the spectral measurement with more features can improve the resolution ability of the neural network, the results reveal that the training with the dataset of the shorter six wavelength is redundant. This analysis shows that it is very important to construct an effective 1D-CNN model area for spectral measurement using the appropriate spectral ranges and number of wavelengths. It shows that our proposed 1D-CNN model gives a new and feasible approach to measure SpO2 based on multi-wavelength.

The NMR Spectral Measurement Database: A System for Organizing and Accessing NMR Spectra of Therapeutic Proteins

The Nuclear Magnetic Resonance Spectral Measurement Database (NMR-SMDB) was developed for the purpose of organizing and searching NMR spectral data of protein therapeutics, linking spectra to corresponding sample information and enabling quick access to full datasets and entire studies. In addition to supporting internal research at the National Institute of Standards and Technology (NIST), the system could facilitate data access to stakeholders outside of NIST, and future versions of the database software itself could be installed by others for their own data storage and retrieval.

Mixed Spectra for Stable Signals from Discrete Observations

This paper concerns the continuous-time stable alpha symmetric processes which are inivitable in the modeling of certain signals with indefinitely increasing variance. Particularly the case where the spectral measurement is mixed: sum of a continuous measurement and a discrete measurement. Our goal is to estimate the spectral density of the continuous part by observing the signal in a discrete way. For that, we propose a method which consists in sampling the signal at periodic instants. We use Jackson's polynomial kernel to build a periodogram which we then smooth by two spectral windows taking into account the width of the interval where the spectral density is non-zero. Thus, we bypass the phenomenon of aliasing often encountered in the case of estimation from discrete observations of a continuous time process.

Automated stopping criterion for spectral measurements with active learning

The automated stopping of a spectral measurement with active learning is proposed. The optimal stopping of the measurement is realised with a stopping criterion based on the upper bound of the posterior average of the generalisation error of the Gaussian process regression. It is revealed that the automated stopping criterion of the spectral measurement gives an approximated X-ray absorption spectrum with sufficient accuracy and reduced data size. The proposed method is not only a proof-of-concept of the optimal stopping problem in active learning but also the key to enhancing the efficiency of spectral measurements for high-throughput experiments in the era of materials informatics.

Review on Speckle-Based Spectrum Analyzer

Accurate spectral measurement and wavelength determination are fundamental and vital for many fields. A compact spectrum analyzer with high performance is expected to meet the growing requirements, and speckle-based spectrum analyzer is a potential solution. The basic principle is based on using the random medium to establish a speckle-to-wavelength mapping relationship for spectrum reconstruction. This article introduces current speckle-based spectrum analyzers with different schemes and reviews recent advances in this field. Besides, some applications by using speckle-based spectrum analyzers are also introduced. Finally, the existing challenges and the future prospects of using speckle for spectrum recovery are discussed.