hepatocyte toxicity
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scholarly journals Development of Novel Diclofenac Analogs Designed to Avoid Metabolic Activation and Hepatocyte Toxicity

ACS Omega ◽  
2020 ◽  
Vol 5 (50) ◽  
pp. 32608-32616
Author(s):  
Yasuhiro Tateishi ◽  
Tomoyuki Ohe ◽  
Mai Ogawa ◽  
Kyoko Takahashi ◽  
Shigeo Nakamura ◽  
...  
Keyword(s):  
Metabolic Activation ◽  
Hepatocyte Toxicity

Predicting direct hepatocyte toxicity in humans by combining high-throughput imaging of HepaRG cells and machine learning-based phenotypic profiling

2020 ◽  
Vol 94 (8) ◽  
pp. 2749-2767 ◽  
Author(s):  
Faezah Hussain ◽  
Sreetama Basu ◽  
Javen Jun Hao Heng ◽  
Lit-Hsin Loo ◽  
Daniele Zink
Keyword(s):  
Machine Learning ◽  
High Throughput ◽  
Heparg Cells ◽  
High Throughput Imaging ◽  
Hepatocyte Toxicity

The Effect of Glutathione on Itraconazole‐Associated Hepatocyte Toxicity in an In Vitro Canine Model

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Natalie M. Kirk ◽  
Miranda D. Vieson ◽  
Kimberly A. Selting ◽  
Jennifer M. Reinhart
Keyword(s):  
Canine Model ◽  
Hepatocyte Toxicity

scholarly journals Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Katherine Shortt ◽  
Daniel P. Heruth ◽  
NiNi Zhang ◽  
Weibin Wu ◽  
Shipra Singh ◽  
...  
Keyword(s):  
Regulatory Genes ◽  
Genome Wide ◽  
A Genome ◽  
Hepatocyte Toxicity

scholarly journals Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine

2016 ◽  
Vol 35 ◽  
pp. 66-76 ◽  
Author(s):  
Smita S. Ghare ◽  
Hridgandh Donde ◽  
Wei-Yang Chen ◽  
David F. Barker ◽  
Leila Gobejishvilli ◽  
...  
Keyword(s):  
Epigenetic Modifications ◽  
Fasl Expression ◽  
Anti Hiv ◽  
Hepatocyte Toxicity

Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes

2015 ◽  
Vol 29 (7) ◽  
pp. 1454-1463 ◽  
Author(s):  
Takeshi Susukida ◽  
Shuichi Sekine ◽  
Eiichiro Ogimura ◽  
Shigeki Aoki ◽  
Kumiko Oizumi ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Cultured Hepatocytes ◽  
Drug Induced ◽  
Hepatocyte Toxicity

scholarly journals Acetaminophen (APAP) hepatocyte toxicity is associated with increased translocation of glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) to the nucleus.

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Nadia Ciriaci ◽  
Belén Vigo ◽  
Juan Rigalli ◽  
Aldo Mottino ◽  
María Ruiz ◽  
...  
Keyword(s):  
Hepatocyte Toxicity

Oxidation Potentials of N-Modified Derivatives of the Analgesic Flupirtine Linked to Potassium KV7 Channel Opening Activity But Not Hepatocyte Toxicity

ChemMedChem ◽  
2014 ◽  
Vol 10 (2) ◽  
pp. 368-379 ◽  
Author(s):  
Christian J. Lemmerhirt ◽  
Mirko Rombach ◽  
Anja Bodtke ◽  
Patrick J. Bednarski ◽  
Andreas Link
Keyword(s):  
Oxidation Potentials ◽  
Channel Opening ◽  
Derivatives Of ◽  
Hepatocyte Toxicity
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