167. Incidence of Acute Kidney Injury with Aminoglycoside Impregnated Foreign Body Implantation

Background During orthopedic surgeries, antibiotic impregnated cement is sometimes used to prevent infection. Elution from these cements can lead to systemically detectable levels of aminoglycosides, a known adverse effect of which is nephrotoxicity. The purpose of this study is to determine if the implantation of aminoglycoside impregnated cement is associated with subsequent development of Acute Kidney Injury (AKI). Methods A retrospective chart review from 1/1/2018-1/1/2021 was conducted to identify a relationship between aminoglycoside impregnated cement and subsequent development of AKI. Data were extracted from Electronic Health Records (Epic) and SAP Business Objects WebI. All patients with knee or hip arthroplasty or hardware removal procedures conducted at a Legacy Health facility during the specified time frame were included. Patients were excluded from the study if < 2 serum creatinine levels were drawn during that hospitalization, AKI occurred prior to the procedure, or dialysis was required at baseline. The primary outcome was development of AKI, a > 150% increase from baseline serum creatinine according to the Acute Kidney Injury Network (AKIN) criteria. The power level was set to 80% with an alpha level of 0.05. A multiple regression analysis was conducted to control for confounding variables Results A total of 2229 patients were included (591 received aminoglycoside cement,1638 did not). Aminoglycoside impregnated cement implantation was not associated with an increased incidence of AKI (1.5% versus 2.3%, P = 0.25). After controlling for covariates, aminoglycoside cement was not associated with development of AKI (adjusted OR 0.68, P = 0.32). Conclusion The results of this study suggest aminoglycoside impregnated foreign body implantation was not associated with a greater incidence of AKI development compared to implantation of foreign bodies lacking aminoglycosides. It is possible that development of AKI post-discharge was not identified in patients with uncomplicated procedures due to omission of lab draws once discharged. Patients admitted for longer durations were more likely to have multiple serum creatinine labs drawn during hospitalization, and likely had multiple comorbid conditions or complications, innately biasing and predisposing AKI development. Disclosures All Authors: No reported disclosures

True grit? Learning points from a facial soft tissue wound

We write this short piece regarding a recently referred case to our oral and maxillofacial surgery (OMFS) unit, which highlights several important learning points for OMFS junior staff. We describe a pertinent case in which the importance of history, examination and relevant investigations during the workup of soft tissue facial injuries is illustrated. Fundamentally, all facial traumatic wounds require a thorough assessment that is performed with a high index of suspicion of foreign body implantation. This case report highlights that all facial traumatic wounds require a thorough assessment performed with a high index of suspicion for foreign body implantation.

Infection Rate in 1033 Elective Neurosurgical Procedures at a University Hospital in South China

Objective Infection following surgery is a serious complication, especially in neurosurgery. The aim of the study is to report the change of incidence rates of infection in patients undergoing elective neurosurgical procedures at a university hospital in South China as well as the risk factors. Material and Methods The medical records and postoperative courses for patients undergoing 1,033 neurosurgical procedures from 2008 to 2014 were reviewed retrospectively to determine the incidence of neurosurgical infection, the identity of the offending organisms, and the factors associated with infection. Results A total of 33 patients (40 cases) experienced postoperative infection representing 3.19% of the study population. Twenty cases were incision infections (1.94%), and 20 were cranial/spinal infections (1.94%) including 15 intracranial infections and 5 intraspinal infections. The 2.4-fold greater incidence of postoperative infection in 2008 to 2010 was compared with that in 2011 to 2014 with perioperative antibiotic prophylaxis (p <0.01). The neurosurgical procedure associated with the highest rate of infection was cranioplasty (6.85%); the lowest rate of infection was associated with functional neurosurgery (1.08%). The most common offending organism was Staphylococcus aureus (27.5%). Foreign body implantation, operative time > 4 hours, and cerebrospinal fluid (CSF) leak (13 infections in 158 patients; p <0.001) were risk factors for infections (p <0.05). Conclusion The neurosurgical infection rate is usually low with perioperative antibiotic prophylaxis even in developing countries. Less foreign body implantation, shorter operative times, and controlling CSF leak could reduce infection rates.

An Unusual Case of Guava Seed Embedded in Buccal Mucosa for Past 6 Months

ABSTRACT Foreign bodies in the oral cavity have included bullets, impression materials, teeth, fish bones, needles, plastics, pistachio nuts, earrings, and the traumatic implantation of a toothbrush and various food products.1 These foreign bodies have been found by, inspection, palpation or as incidental findings on radiographs. A thorough history may establish an etiology and timeframe in which the foreign body was embedded in soft-tissue. Foreign body implantation has been reported in the literature from long but exact nature of the specimen is not always revealed. This article documents a case of a foreign body which was a guava seed embedded in buccal mucosa for 6 months which was ruled out by its typical radiographic presentation. How to cite this article Sharma S, Bumb D, Sen S, Priyadardshini S. An Unusual Case of Guava Seed Embedded in Buccal Mucosa for Past 6 Months. World J Dent 2014; 5(3):193-195.

Mitigation of free radical toxicity in hyperoxaluric condition by a novel derivative eicosapentaenoate-lipoate

Lipoic acid (LA) and eicosapentaenoic acid (EPA) have been shown to ameliorate the changes associated with hyperoxaluria. This prompted us to study the effect of EPA-LA, a new derivative, in experimental urolithiatic condition. Foreign body implantation method followed by supple-mentation of ammonium oxalate was adopted to induce stone formation in the bladder. Significant depletion in the antioxidant status was observed in the kidney and bladder of stone-forming animals, associated with increased lipid peroxidation. The present observations provide supporting evidence to the hypothesis that free radicals might be involved in causing toxicity in hyperoxaluric condition. The three drugs, namely LA, EPA and EPA-LA had reversed the above changes, but the effect was more pronounced in EPA-LA-treated stone formers. These features highlight the beneficial effect of EPA-LA wherein the potency of two drugs has been combined. The practical outcome of these findings is that the cellular antioxidant defence can be increased by the supplementation of lipoate and its derivative EPA-LA. Human & Experimental Toxicology (2002) 21, 153–158.