The interrelation of Smoking and changes of rheological properties of blood of women of fertile age is studied and established. On the basis of the Samara city polyclinic, the results of blood parameters were studied in 107 smokers and 136 non-smokers of fertile age, observed in the women’s clinic. The study found that Smoking helps to reduce blood clotting time, increase the number of red blood cells, blood hemoglobin. Under the influence of Smoking increases blood coagulating activity. Cessation of Smoking causes a decrease in hematocrit, hemoglobin concentration. Active detection of Smoking adolescents, as well as Smoking relatives in the family, preventive measures, including the organization of schools for the treatment of tobacco dependence, will significantly reduce the likelihood of severe chronic multiple organ disease.