Background :
The presence of condensed tannins, flavonones, flavonols, flavones, xantones, catechins and
alkaloids in the ethanolic extract of Lantana undulata leaves has been associated to cytotoxicity and virucidal effect on suid
herpesvirus.
Objective:
Evaluate cellular toxicity, antimicrobial and antioxidant activities, and anti-phlogistic property of the ethanolic
extract leaves Lantana undulata, a plant from Verbenaceae family.
Method:
Cytotoxicity was evaluated on Madin Darby bovine kidney (MDBK) cells and erythrocytes and through leukocyte
DNA damage. Antibacterial and antifungal activities were performed using agar diffusion technique and broth
microdilution. The inhibition percentage and viral inhibition index were stablished against bovine herpesvirus. The
antioxidant effect (EC50) was determined by the DPPH technique and the mouse ear edema model was used to determine
the anti-phlogistic activity.
Results:
The maximum nontoxic concentration for MDBK cells was 650 µg/ml. The ethanolic extract of L. undulata was
considered non-hemolytic from 2 to 16 μg/ml and not genotoxic at concentration tested (<8 μg/ml). High concentrations
(≥500 µg/ml) were needed to inhibit bacteria and yeasts, and the action of the extract was bacteriostatic or fungistatic. The
IIV was of 0.37 and the IP was of 57.34% against bovine herpesvirus. The antioxidant EC50 was 540.87 μg/ml and the
reduction of oedema occurred at 10, 30 and 100 mg/kg in the mouse model used.
Conclusion:
Although the leaves ethanolic extract of L. undulata showed to be potentially toxic and to have a reduced
spectrum of action on microorganisms, the outstanding antiphlogistic action puts the therapeutic potential of this plant into
perspective.
Effect of Feed Supplemented with Selenium-Enriched Olive Leaves on Plasma Oxidative Status, Mineral Profile, and Leukocyte DNA Damage in Growing Rabbits