Sweet potato (Ipomea batatas) is a plant found mostly in America. The rich content of flavonoid in sweet potato which acts as anti-oxidant can prevent premature aging and can also protect cells from damages caused by free-radicals. Flavonoid possesses an anti-bacterial nature which can disturb the cell wall function of bacteria through the mechanism of complex formation with extracellular protein. This article is written using narrative review method through electronic scientific article, journal, and textbook. Authors identified 16 articles which published from 2010-2020. Out of 16 articles, 11 of them were in match to the criteria and the results were found that the physical characteristics of anti-acne spray gel can be determined through the dispersibility test, organoleptic test, adhesivity, dry time, and stability test. For the biological characteristic of spray gel can be done using Well method for the Propinibacterium acnes. Sweet potato-based spray gel possesses physical and biological characteristic which can slows bacterial growth significantly compared to green tea shoots and purple leaf.