Adipose Stem Cell-Based Treatments for Wound Healing

Wound healing is one of the most complex physiological regulation mechanisms of the human body. Stem cell technology has had a significant impact on regenerative medicine. Adipose stem cells (ASCs) have many advantages, including their ease of harvesting and high yield, rich content of cell components and cytokines, and strong practicability. They have rapidly become a favored tool in regenerative medicine. Here, we summarize the mechanism and clinical therapeutic potential of ASCs in wound repair.

Characterization of a Novel Mitovirus Infecting Melanconiella theae Isolated From Tea Plants

A dsRNA segment was identified in the fungus Melanconiella theae isolated from tea plants. The complete dsRNA sequence, determined by random cloning together with RACE protocol, is 2,461 bp in length with an AU-rich content (62.37%) and comprises a single ORF of 2,265-nucleotides encoding an RNA-dependent RNA-polymerase (RdRp, 754 amino acids in size). The terminus sequences can fold into predicted stable stem-loop structures. A BLASTX and phylogenetic analysis revealed the dsRNA genome shows similarities with the RdRp sequences of mitoviruses, with the highest identity of 48% with those of grapevine-associated mitovirus 20 and Colletotrichum fructicola mitovirus 1. Our results reveal a novel member, tentatively named Melanconiella theae mitovirus 1 (MtMV1), belongs to the family Mitoviridae. MtMV1 is capsidless as examined by transmission electron microscope, efficiently transmitted through conidia as 100 conidium-generated colonies were analyzed, and easily eliminated by hyphal tipping method combined with green-leaf tea powder. MtMV1 has a genomic sequence obviously divergent from those of most members in the family Mitoviridae and some unique characteristics unreported in known members. This is the first report of a mycovirus infecting Melanconiella fungi to date.

Status Quo of Piano Coach in China

The major of piano coach nowadays has a large market demand and is promising in China, and should be attached great importance. However, many music learners in China believe that the students of the piano studies major are sufficiently competent in the work of piano coach, and they often confuse piano coach with piano accompaniment. Although the two majors both require deep understanding of music and good performance skills, they are different in many aspects. The piano coach requires practitioners to have rigorous logic, rich content, corresponding mastery and understanding of the universal law of art and other qualities.

Pharmacological Role of Ostericum koreanum: A Short Viewpoint

Ostericum koreanum Maxim., a perennial medicinal plant native to Asian countries, is traditionally exploited in Korean Oriental and Chinese Herbal Medicine. It has been used in the treatment of neuralgia, respiratory problems, and joint pain due to its rich content of phytochemicals. Therefore, the significant role of compounds present in O. koreanum should not be overlooked to explore and develop drugs against diseases. The purpose of this review is to provide a reference for researchers and to describe the phytochemical constituents and pharmacological activity of O. koreanum. In this mini review, we have collected the data from 1980 to 2020 regarding the phytochemicals present and pharmacological activities of this plant. Our findings indicated that this plant possesses a rich source of phytochemicals that have significant pharmacological activities, such as anti-microbial, anti-inflammatory, anti-pyretic, anti-influenza, anti-cancer, and neuroprotective. These phytochemicals have promising pharmacological activity which should be further explored for the treatment of various diseases.

The Twenty-Four Egyptian Days in Yiddish

The object of this study is a list of twenty-four Egyptian days in Yiddish discovered at the end of a Hebrew miscellany from medieval Ashkenaz, preserved in the Basel Universitätsbibliothek. Egyptian days are inauspicious days for bloodletting; these are listed according to the Julian calendar and sometimes identified by saint names and feast days. The list is edited and translated into English. Dates and variants of these Egyptian days are then compared with those of the only other known list of its kind, found in the earliest dated astro-medical fragment in Old Western Yiddish, from 1396–1397. A tabular comparison and descriptive commentary of the names and dates in both lists follows. Preceding this analysis, the status and knowledge of Jewish physicians in medieval Ashkenaz is addressed, as well as a brief description of Ms R IV 2, revealing its rich content and some of its codicological and paleographical characteristics.

3D Modeling and Animation Design of Flying Apsaras in Dunhuang Frescoes

With rich content and long history, flying Apsaras in Dunhuang frescoes is precious material for studying the artistic style and artistic modeling of ancient Chinese murals. This article aims to explore the 3D modeling and video animation design of flying Apsaras in Dunhuang frescoes, which not only provides Dunhuang Museum with digital cultural heritage content and popular science materials, but also helps develop cultural heritage protection methods and encourages further exploration of Chinese historic art.

Ancient mural classification methods based on a multichannel separable network

Ancient murals are of high artistic value and boast rich content. The accurate classification of murals is a challenging task for researchers and can be arduous even for experienced researchers. The image classification algorithms currently available are not effective in the classification of mural images with strong background noise. A new multichannel separable network model (MCSN) is proposed in this study to solve this issue. Using the GoogLeNet network model as the basic framework, we adopt a small convolution kernel for the extraction of the shallow-layer background features of murals and then decompose larger, two-dimensional convolution kernels into smaller convolution kernels, for example, 7 × 7 and 3 × 3 kernels into 7 × 1 and 1 × 7 kernels and 3 × 1 and 1 × 3 kernels, respectively, to extract important deep-layer feature information. A soft thresholding activation scaling strategy is adopted to enhance the stability of the network during training, and finally, the murals are classified through the softmax layer. A minibatch SGD algorithm is employed to update the parameters. The accuracy, recall and F1-score reached 88.16%, 90.01%, and 90.38%, respectively. Compared with mainstream classification algorithms, the model demonstrates improvement in terms of classification accuracy, generalizability, and stability to a certain extent, supporting its suitability in efficiently classifying murals.

PhaLP: A Database for the Study of Phage Lytic Proteins and Their Evolution

Phage lytic proteins are a clinically advanced class of novel enzyme-based antibiotics, so-called enzybiotics. A growing community of researchers develops phage lytic proteins with the perspective of their use as enzybiotics. A successful translation of enzybiotics to the market requires well-considered selections of phage lytic proteins in early research stages. Here, we introduce PhaLP, a database of phage lytic proteins, which serves as an open portal to facilitate the development of phage lytic proteins. PhaLP is a comprehensive, easily accessible and automatically updated database (currently 16,095 entries). Capitalizing on the rich content of PhaLP, we have mapped the high diversity of natural phage lytic proteins and conducted analyses at three levels to gain insight in their host-specific evolution. First, we provide an overview of the modular diversity. Secondly, datamining and interpretable machine learning approaches were adopted to reveal host-specific design rules for domain architectures in endolysins. Lastly, the evolution of phage lytic proteins on the protein sequence level was explored, revealing host-specific clusters. In sum, PhaLP can act as a starting point for the broad community of enzybiotic researchers, while the steadily improving evolutionary insights will serve as a natural inspiration for protein engineers.

Prospects for the Production of Aromatized Wines Enriched with Biologically Active Compounds

Within the experiment, for preparation of the aromatized wines, enriched with biologically active compounds, were used the endemic medicinal plants and fruits. In the control and trial samples, by application of high performance liquid chromatography, were determined the content of total phenols, resveratrol, quercetin, myricetin and micronutrients. Compared to the corresponding control samples – sweet fortified wine, Saperavi and Hawthorn Red Aromatized Wine contents 21%, and Rkatsiteli, Kiwi and Elecampane White Aromatized Wine, 18.25% more total phenols. Based on conducted analyses, the trial samples contain twice more antioxidants, than they are typically identified in wines: Saperavi, Blackberry, Plum and Leonurus Red Aromatized Wine is characterized with the rich content of resveratrol, while, Rkatsiteli, buckthorn and balm with - quercetin and myricetin. These compounds are widely used in pharmaceutical industry. The enrichment of wines with these antioxidant is achieved by the usage of plants and herbs. Besides, the selected materials influenced on micronutrients, their content is also significantly increased. The obtained results confirm, that the selected materials and worked out recipes are effective for the production of beverages that have a positive effect on the human health.