microsomal glutathione
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2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Sussie Dalvin ◽  
Christiane Eichner ◽  
Michael Dondrup ◽  
Aina-Cathrine Øvergård

Abstract Background The salmon louse (Lepeophtheirus salmonis) is a parasite of salmonid fish. Atlantic salmon (Salmo salar) exhibit only a limited and ineffective immune response when infested with this parasite. Prostaglandins (PGs) have many biological functions in both invertebrates and vertebrates, one of which is the regulation of immune responses. This has led to the suggestion that prostaglandin E2 (PGE2) is important in the salmon louse host–parasite interaction, although studies of a salmon louse prostaglandin E2 synthase (PGES) 2 gene have not enabled conformation of this hypothesis. The aim of the present study was, therefore, to characterize two additional PGES-like genes. Methods Lepeophtheirus salmonis microsomal glutathione S-transferase 1 like (LsMGST1L) and LsPGES3L were investigated by sequencing, phylogenetics, transcript localization and expression studies. Moreover, the function of these putative PGES genes in addition to the previously identified LsPGES2 gene was analyzed in double stranded (ds) RNA-mediated knockdown (KD) salmon louse. Results Analysis of the three putative LsPGES genes showed a rather constitutive transcript level throughout development from nauplius to the adult stages, and in a range of tissues, with the highest levels in the ovaries or gut. DsRNA-mediated KD of these transcripts did not produce any characteristic changes in phenotype, and KD animals displayed a normal reproductive output. The ability of the parasite to infect or modulate the immune response of the host fish was also not affected by KD. Conclusions Salmon louse prostaglandins may play endogenous roles in the management of reproduction and oxidative stress and may be a product of salmon louse blood digestions. Graphic Abstract





2020 ◽  
Vol 121 ◽  
pp. 109562 ◽  
Author(s):  
Baozhen Zeng ◽  
Chunlei Ge ◽  
Ruilei Li ◽  
Zhiwei Zhang ◽  
Qiaofen Fu ◽  
...  


2019 ◽  
Vol 38 (10) ◽  
pp. 111-115
Author(s):  
Wenjie Yan ◽  
Jiao Liu ◽  
Samphal Seng ◽  
Bin Zhou ◽  
Kuke Ding


2019 ◽  
Author(s):  
Jie Zhang ◽  
Zhi-wei Ye ◽  
Danyelle M. Townsend ◽  
Ralf Morgenstern ◽  
Kenneth D. Tew


2019 ◽  
Author(s):  
Jie Zhang ◽  
Zhi-wei Ye ◽  
Danyelle M. Townsend ◽  
Ralf Morgenstern ◽  
Kenneth D. Tew


2017 ◽  
Vol 91 ◽  
pp. 114-122 ◽  
Author(s):  
Zhen Zhang ◽  
Zhimeng Lv ◽  
Zhixin Wei ◽  
Chenghua Li ◽  
Yina Shao ◽  
...  


PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3935 ◽  
Author(s):  
Jingjing Zhang ◽  
Toshihiko Matsuo

Background/AimStrabismus is a common condition with misalignment between two eyes that may lead to decrease of visual acuity, lack of binocularity, and diplopia. It is caused by heterogeneous environmental and genetic risk factors. Our previous research has identified new chromosomal susceptibility loci in 4q28.3 and 7q31.2 regions for comitant strabismus in Japanese families. We conducted a verification study by linkage analysis to narrow the chromosomal loci down to a single gene.MethodsFrom Japanese and U.S. databases, 24 rsSNPs and 233 rsSNPs were chosen from the 4q28.3 and 7q31.2 region, respectively, and were typed in 108 affected subjects and 96 unaffected subjects of 58 families with primary and non-syndromic comitant strabismus. Three major analytical methods were used: transmission disequilibrium test (TDT), TDT allowing for errors (TDTae), and linkage analysis under dominant and recessive inheritance.ResultsThe SNPs with significantPvalues in TDT and TDTae were located solely at the gene, microsomal glutathione S-transferase 2 (MGST2), on chromosome 4q28.3 locus. In contrast, significant SNPs were dispersed in a few genes, containing wingless-type MMTV integration site family member 2 (WNT2), on chromosome 7q31.2 locus. The distribution of significant SNPs on the 7q31.2 locus showed that only theST7toWNT2region in the same big haplotype block contained significant SNPs for all three methods of linkage analysis.ConclusionsThis study suggests thatMGST2andWNT2are potential candidates for comitant strabismus in Japanese population.



2017 ◽  
Vol 275 ◽  
pp. 116-120
Author(s):  
Mireille M.J.P.E. Sthijns ◽  
Gertjan J.M. den Hartog ◽  
Caterina Scasso ◽  
Jan P. Haenen ◽  
Aalt Bast ◽  
...  


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