Radical pairs can explain magnetic field and lithium effects on the circadian clock

Drosophila’s circadian clock can be perturbed by magnetic fields, as well as by lithium administration. Cryptochromes are critical for the circadian clock. Further, the radical pairs in cryptochrome also can explain magnetoreception in animals. Based on a simple radical pair mechanism model of the animal magnetic compass, we show that both magnetic fields and lithium can influence the spin dynamics of the naturally occurring radical pairs and hence modulate the circadian clock’s rhythms. Using a simple chemical oscillator model for the circadian clock, we show that the spin dynamics influence a rate in the chemical oscillator model, which translates into a change in the circadian period. Our model can reproduce the results of two independent experiments, magnetic field and lithium effects on the circadian clock. Our model predicts that stronger magnetic fields would shorten the clock’s period. We also predict that lithium influences the clock in an isotope-dependent manner. Furthermore, our model also predicts that magnetic fields and hyperfine interactions modulate oxidative stress. The findings of this work suggest that the quantum nature of radical pairs might play roles in the brain, as another piece of evidence in addition to recent results on xenon anesthesia and lithium effects on hyperactivity.

Radical pairs can explain magnetic field and lithium effects on the circadian clock

Drosophila's circadian clock can be perturbed by magnetic fields, as well as by lithium administration. Cryptochromes are critical for the circadian clock. Further, the radical pairs in cryptochrome also can explain magnetoreception in animals. Based on a simple radical pair mechanism model of the animal magnetic compass, we show that both magnetic fields and lithium can influence the spin dynamics of the naturally occurring radical pairs and hence modulate the circadian clock's rhythms. Using a simple chemical oscillator model for the circadian clock, we show that the spin dynamics influence a rate in the chemical oscillator model, which translates into a change in the circadian period. Our model can reproduce the results of two independent experiments, magnetic fields and lithium effects on the circadian clock. Our model predicts that stronger magnetic fields would shorten the clock's period. We also predict that lithium influences the clock in an isotope-dependent manner. Furthermore, our model also predicts that magnetic fields and hyperfine interactions modulate oxidative stress. The findings of this work suggest that quantum nature and entanglement of radical pairs might play roles in the brain, as another piece of evidence in addition to recent results on xenon anesthesia and lithium effects on hyperactivity.

Study of Lotka–Volterra Biological or Chemical Oscillator Problem Using the Normalization Technique: Prediction of Time and Concentrations

The normalization of dimensionless groups that rule the system of nonlinear coupled ordinary differential equations defined by the Lotka–Volterra biological or chemical oscillator has been derived in this work by applying a normalized nondimensionalization protocol. The normalization procedure, which is quite accurate, does not require complex mathematical steps; however, a deep physical understanding of the problem is required to choose the appropriate references to define the dimensionless variables. From the dimensionless groups derived, the functional dependences of some unknowns of interest are established. Due to the coupled nature of the problem that induces temporal concentration rates of each species that are quite different at each point of the phase diagram, this diagram has been divided into four stretches corresponding to the four quadrants. For each stretch, the limit values (maximum or minimum) of the variables, as well as their duration, are expressed in terms of the dimensionless groups derived before. Finally, to check all the mentioned dependences, a numerical simulation has been carried out.

Dynamical regime of resorcinol based Belousov–Zhabotinsky chemical oscillator in the presence or absence of some hydrophobic antioxidants in aqueous–organic mixed media

BZ reaction acts as radical generator in AN/DMF mixed solvent system.