Template-controlled synthesis of chiral cyclohexylhemicucurbit[8]uril

Efficient control of macrocycle size was achieved by dynamic covalent chemistry and anionic template.

Kinetic Analysis for Macrocyclizations Involving Anionic Template at the Transition State

Several kinetic models for the macrocyclization of aC2pseudopeptide with a dihalide through aSN2reaction have been developed. These models not only focus on the kinetic analysis of the main macrocyclization reaction, but also consider the competitive oligomerization/polymerization processes yielding undesired oligomeric/polymeric byproducts. The effect of anions has also been included in the kinetic models, as they can act as catalytic templates in the transition state reducing and stabilizing the transition state. The corresponding differential equation systems for each kinetic model can be solved numerically. Through a comprehensive analysis of these results, it is possible to obtain a better understanding of the different parameters that are involved in the macrocyclization reaction mechanism and to develop strategies for the optimization of the desired processes.

Synthesis and Characterization of Nano Crystalline Hydroxyapatite Spheroids Using Anionic Template for Bio Applications

Nano crystalline Hydroxyapatite (HAp) spheroids of uniform size distribution of diameter ~200 nm have been prepared by co-precipitation method at room temperature. The anionic surfactant SDS has been used as the template material. The calcinated samples were subjected to FTIR and XRD characterizations to confirm the phase of HAp. The Ca/P ratio that has been measured from the EDS spectrum 1.69 has good agreement with the theoretical value. The SEM and TEM images reveal the nano spherical nature and narrow size distribution of the HAp particles, which were good candidates for drug delivery applications.