Evaluating interactions between emotion regulation strategies through the interpersonal context of female friends

Introduction: There is a growing interest in examining how interpersonal relationships may shape associations between emotion regulation (ER) strategies and psychopathology.Methods: We used multilevel modeling to test if respondents’ self-reported intrapersonal ER, friends’ self-reported intrapersonal ER, and their interaction were associated with psychopathology in a sample of 120 female friend dyads.Results: Respondents’ use of brooding rumination, expressive suppression, and worry were positively associated with respondent psychopathology. Friend reappraisal moderated the association between respondent reappraisal and respondent psychopathology. Consistent with an interference hypothesis, respondent cognitive reappraisal was only associated with respondent psychopathology when friend cognitive reappraisal was low. Consistent with a compensatory hypothesis, respondent reappraisal was primarily associated with respondent psychopathology when friend repetitive negative thought was high.Discussion: Results support the extension of models of ER strategy interactions from intrapersonal to interpersonal contexts. Future research is needed to replicate the interference and compensatory interactions observed in the data.

Sympathetic baroreflex sensitivity is inversely related to vascular transduction in men but not women

Sympathetic baroreflex sensitivity (BRS) is a measure of how effectively the baroreflex buffers beat-to-beat changes in blood pressure through the modulation of muscle sympathetic nerve activity (MSNA). However, current methods of assessment do not take into account the transduction of sympathetic nerve activity at the level of the vasculature, which is known to vary between individuals. In this study we tested the hypothesis that there is an inverse relationship between sympathetic BRS and vascular transduction. In 38 (18 men) healthy adults, continuous measurements of blood pressure, MSNA and superficial femoral artery diameter and blood flow (Doppler ultrasound) were recorded during 10 min of rest. Spontaneous sympathetic BRS was quantified as the relationship between diastolic pressure and MSNA burst incidence. Vascular transduction was quantified by plotting the changes in leg vascular conductance for 10 cardiac cycles following each burst of MSNA, and taking the nadir. In men, sympathetic BRS was inversely related to vascular transduction ( r = −0.49; P = 0.04). However, this relationship was not present in women ( r = −0.17; P = 0.47). To conclude, an interaction exists between sympathetic BRS and vascular transduction in healthy men, such that men with high sympathetic BRS have low vascular transduction and vice versa. This may be to ensure that blood pressure is regulated effectively, although further research is needed to explore what mechanisms are involved and examine why this relationship was not apparent in women. NEW & NOTEWORTHY Evidence suggests that compensatory interactions exist between factors involved in cardiovascular control. This study was the first to demonstrate an inverse relationship between sympathetic BRS and beat-to-beat vascular transduction. Those with low sympathetic BRS had high vascular transduction and vice versa. However, this interaction was present in young men but not women.

The roles of vision and antennal mechanoreception in hawkmoth flight control

Flying animals need continual sensory feedback about their body position and orientation for flight control. The visual system provides essential but slow feedback. In contrast, mechanosensory channels can provide feedback at much shorter timescales. How the contributions from these two senses are integrated remains an open question in most insect groups. In Diptera, fast mechanosensory feedback is provided by organs called halteres and is crucial for the control of rapid flight manoeuvres, while vision controls manoeuvres in lower temporal frequency bands. Here, we have investigated the visual-mechanosensory integration in the hawkmoth Macroglossum stellatarum. They represent a large group of insects that use Johnston’s organs in their antennae to provide mechanosensory feedback on perturbations in body position. Our experiments show that antennal mechanosensory feedback specifically mediates fast flight manoeuvres, but not slow ones. Moreover, we did not observe compensatory interactions between antennal and visual feedback.

Genetic robustness and functional evolution of gene duplicates

Gene duplications are a major source of evolutionary innovations. Understanding the functional divergence of duplicates and their role in genetic robustness is an important challenge in biology. Previously, analyses of genetic robustness were primarily focused on duplicates essentiality and epistasis in several laboratory conditions. In this study, we use several quantitative data sets to understand compensatory interactions between Saccharomyces cerevisiae duplicates that are likely to be relevant in natural biological populations. We find that, owing to their high functional load, close duplicates are unlikely to provide substantial backup in the context of large natural populations. Interestingly, as duplicates diverge from each other, their overall functional load is reduced. At intermediate divergence distances the quantitative decrease in fitness due to removal of one duplicate becomes smaller. At these distances, yeast duplicates display more balanced functional loads and their transcriptional control becomes significantly more complex. As yeast duplicates diverge beyond 70% sequence identity, their ability to compensate for each other becomes similar to that of random pairs of singletons.