Intertwin differences in umbilical artery pulsatility index are associated with infant survival in twin-to-twin transfusion syndrome

Objectives To evaluate the association of intertwin differences in umbilical artery pulsatility index (DUAPI) and infant survival in twin-to-twin transfusion syndrome (TTTS). Methods Absolute DUAPI was calculated prior to laser surgery. Receiver-operating characteristics (ROC) curve analysis provided an intertwin DUAPI cutoff of 0.4 for the prediction of double twin survival to 30 days of life. Infant survival was compared between women with an intertwin DUAPI <0.4 and ≥0.4 in the whole cohort, in TTTS cases with Quintero stages I/II and in those with Quintero stages III/IV. Regression analyses were performed to evaluate the association of intertwin DUAPI <0.4 and infant survival adjusted for confounders. Results In total, 349 TTTS cases were included. Double twin survival to 30 days was observed in 67% (234/349) of cases. Significant differences in double twin survival was seen between intertwin DUAPI groups in the whole cohort (76.8 vs. 52.2%; p<0.001), in women with TTTS Quintero stage I or II (77.8 vs. 58.5%; p=0.015) as well as in women with TTTS Quintero stage III or IV (75 vs. 49.5%; p=0.001). Intertwin DUAPI <0.4 conferred a threefold increased chance for double twin survival. Conclusions Small intertwin DUAPI is associated with increased double infant survival in early and advanced TTTS stages.

CzeV1731: The unique doubly eclipsing quadruple system

We report the discovery of the relatively bright (V = 10.5 mag), doubly eclipsing 2+2 quadruple system CzeV1731. This is the third known system of its kind, in which the masses are determined for all four stars and both the inner and outer orbits are characterized. The inner eclipsing binaries are well-detached systems moving on circular orbits: pair A with period PA = 4.10843 d and pair B with PB = 4.67552 d. The inner binaries contain very similar components (q ≈ 1.0), making the whole system a so-called double twin. The stars in pair B have slightly larger luminosities and masses and pair A shows deeper eclipses. All four components are main-sequence stars of F/G spectral type. The mutual orbit of the two pairs around the system barycenter has a period of about 34 yr and an eccentricity of about 0.38. However, further observations are needed to reveal the overall architecture of the whole system, including the mutual inclinations of all orbits. This is a promising target for interferometry to detect the double at about 59 mas and ΔMbol < 1 mag.