Salient features of maximum temperature distribution over Tamil Nadu

In this paper an attempt is made to study the spatial variations of maximum temperature over Tamil Nadu. From the data of daily maximum temperature of eleven stations in Tamil Nadu for the first six months from 1981 to 1997, it is observed that there are two separate regions namely high maximum temperature region of interior stations and low maximum temperature region of coastal stations from January to May and the distinction disappears in June. Hill station Kodaikanal recorded less maximum temperature that Ootacamund from January to May and it reverses in June. During onset phase of southwest monsoon, maximum temperature decreases over Coimbatore, Pamban and Kanyakumari. In the presence of cyclonic storm over the Bay of Bengal the maximum temperatures are fallen during the period when the storm affects Tamil Nadu or Andhra coast in May and June whereas when the storms moves farther away from the coast maximum temperature over interior places decreases and increases over north coastal stations.

Contrasting movement of wind based equatorial trough and equatorial cloud zone over Indian southern peninsula and adjoining Bay of Bengal during the onset phase of northeast monsoon

ABSTRACT. The northeast monsoon sets in over southern parts of peninsular India after the retreat of southwest monsoon and in association with the southward movement of equatorial trough. The INSAT satellite imageries scrutinised during the past several years revealed that the cloud bands at the time of northeast monsoon onset moved from south Bay into the southern peninsula, a feature that contrasts with the north to south movement of the equatorial trough. The paper investigates this aspect based on a dataset of lower level upper winds of the peninsula, rainfall data and INSAT OLR data for the 20 year period 1981–2000. The super epoch profiles of zonal winds, latitudinal position of equatorial trough with reference to northeast monsoon onset dates have been derived and studied. The region with OLR values less than 230 W/m2 was defined as the equatorial cloud zone and the movement of northern limit of ECZ was studied based on the normal pentad OLR data and also the superposed epoch profiles. From these analysis it has been established that at the time of northeast monsoon onset, the wind based equatorial trough moves south of Comorin whereas the cloud zone in the Bay of Bengal moves from south to north. Reasons for the occurrence of such a contrasting feature have been ascribed to features such as decreasing strength of lower level easterlies from north to south over coastal Tamil Nadu, reversal of temperature gradient between Chennai and Thiruvananthapuram at the time of onset and the dynamics of 40-day oscillation. The northeast monsoon activity over coastal Tamil Nadu has been found to be negatively correlated with the low level zonal winds over the coast, the degree of relation decreasing from north to south and also from October to December. Based on the results derived in the study and also the other known features of northeast monsoon a thematic model of northeast monsoon onset listing the events that precede and succeed the onset has been postulated.

Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination

Background Brain astroglia are activated preceding the onset of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). We characterized the effects of brain astroglia on spinal cord inflammation, focusing on astroglial connexin (Cx)43, because we recently reported that Cx43 has a critical role in regulating neuroinflammation. Methods Because glutamate aspartate transporter (GLAST)+ astroglia are enriched in the brain gray matter, we generated Cx43fl/fl;GLAST-CreERT2/+ mice that were brain gray matter astroglia-specific Cx43 conditional knockouts (Cx43 icKO). EAE was induced by immunization with myelin oligodendroglia glycoprotein (MOG) 35–55 peptide 10 days after tamoxifen injection. Cx43fl/fl mice were used as controls. Results Acute and chronic EAE signs were significantly milder in Cx43 icKO mice than in controls whereas splenocyte MOG-specific responses were unaltered. Histologically, Cx43 icKO mice showed significantly less demyelination and fewer CD45+ infiltrating immunocytes, including F4/80+ macrophages, and Iba1+ microglia in the spinal cord than controls. Microarray analysis of the whole cerebellum revealed marked upregulation of anti-inflammatory A2-specific astroglia gene sets in the pre-immunized phase and decreased proinflammatory A1-specific and pan-reactive astroglial gene expression in the onset phase in Cx43 icKO mice compared with controls. Astroglia expressing C3, a representative A1 marker, were significantly decreased in the cerebrum, cerebellum, and spinal cord of Cx43 icKO mice compared with controls in the peak phase. Isolated Cx43 icKO spinal microglia showed more anti-inflammatory and less proinflammatory gene expression than control microglia in the pre-immunized phase. In particular, microglial expression of Ccl2, Ccl5, Ccl7, and Ccl8 in the pre-immunized phase and of Cxcl9 at the peak phase was lower in Cx43 icKO than in controls. Spinal microglia circularity was significantly lower in Cx43 icKO than in controls in the peak phase. Significantly lower interleukin (IL)-6, interferon-γ, and IL-10 levels were present in cerebrospinal fluid from Cx43 icKO mice in the onset phase compared with controls. Conclusions The ablation of Cx43 in brain gray matter astroglia attenuates EAE by promoting astroglia toward an anti-inflammatory phenotype and suppressing proinflammatory activation of spinal microglia partly through depressed cerebrospinal fluid proinflammatory cytokine/chemokine levels. Brain astroglial Cx43 might be a novel therapeutic target for MS.

Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation

Immune tolerance research is essential for kidney transplantation. Other than antibody and T cell-mediated immune rejection, macrophage-mediated innate immunity plays an important role in the onset phase of transplantation rejection. However, due to the complexity of the kidney environment as well as its diversity and low abundance, studies pertaining to monocyte/macrophages in kidney transplantation require further elucidation. In this study, kidney samples taken from healthy human adults and biopsy specimens from patients undergoing rejection following kidney transplantation were analysed and studied. By conducting a single-cell RNA analysis, the type and status of monocyte/macrophages in kidney transplantation were described, in which monocyte/macrophages were observed to form two different subpopulations: resident and infiltrating monocyte/macrophages. Furthermore, previously defined genes were mapped to all monocyte/macrophage types in the kidney and enriched the differential genes of the two main subpopulations using gene expression databases. Considering that various cases of rejection may be of the monocyte/macrophage type, the present data may serve as a reference for studies regarding immune tolerance following kidney transplantation.