Organic nanoelectronics inside us: charge transport and localization in RNA could orchestrate ribosome operation

Translation—protein synthesis at the ribonucleic acid (RNA) based molecular machine, ribosome, — proceeds in a similar manner in all life forms. However, despite several decades of research, the physics underlying this process remains enigmatic. Specifically, during translation, a ribosome undergoes large-scale conformational changes of its distant parts, and these motions are precisely synchronized by an unknown mechanism. In this study, we suggest that such a mechanism could be related to charge (electron hole) transport along and between the RNA molecules, localization of these charges at certain sites and successive relaxation of molecular geometry. Thus, we suppose that RNA-based molecular machines, e.g., ribosome, are electronically controlled, having “wires”, “actuators”, “battery”, and other “circuitry”. Taking transfer RNA as an example, we justify the reasonability of our suggestion using ab initio and atomistic simulations. We anticipate that our findings will qualitatively advance the understanding of the key biological processes and could inspire novel approaches in medicine.

Transient Rotational Flow of Radiative Nanofluids over an Impermeable Riga Plate with Variable Properties

The present investigation imparts an analysis on the effect of time-varying rotation and thermal radiation on diversified nanofluids possessing water as base fluid and Magnetite , Cupper Oxide (CuO), and Titania (TiO) as nanoparticles. Variable fluid properties such as variable viscosity and variable thermal conductivity are taken into consideration. Ensuring implementation, Successive Relaxation method is the instrumental in obtaining the most appropriate numerical solution of the transformed differential equations. One of the marvel outcomes of the current study is that moderate rotation reduces the axial and transverse wall shear stresses and augments the heat transfer rate while higher rotation exhibits the reverse trend for Water-Magnetite, Water-Cupper Oxide, Water-Titania nanofluids.

Psycho-Physiological Approaches to Assessing the Effectiveness of a Comprehensive Program of Psychological Correction on the Basis of Body-Oriented Psychotherapy

In the present time the methods of psychotherapy for correction of prenosological states have no objective criteria in the selection of targets of influence, and in evaluating the effectiveness of applied psychotherapeutic techniques. In this regard, the purpose of this study is devoted to a psycho-physiological evaluation of effectiveness of the developed complex body-oriented psychotherapy. On the basis of the developed psychotherapeutic techniques of body-oriented effects, the authors surveyed 70 respondents of dangerous professions. The exchange control efficiency was carried out according to variational pulsometry by Baevsky R. M. and spectral analysis of heart rhythm, the complex physiological and psychological methods (i.e. «Simple visual-motor reaction», «Reaction to a moving object»). The use of the developed program complex psychological correction on the basis of body-oriented psychotherapy, consisting of successive relaxation techniques and mobilization, allows to reduce a functional stress adaptation mechanisms, an emotional stress and the severity of stress reactions in persons with psycho-physiological disorders, and also to raise the functional reserves of the organism, the functional state of the nervous system and stress (statistically significant dynamics of the indicator "Stability of reaction", "Total deviation from autologous standards) in healthy people. It is stated a vegeto-stabilizing action of the developed complex (according to the assessment of HRV).