Multi-Modal Mass Spectrometric Imaging of Uveal Melanoma

Matrix assisted laser desorption ionisation mass spectrometry imaging (MALDI-MSI), was used to obtain images of lipids and metabolite distribution in formalin fixed and embedded in paraffin (FFPE) whole eye sections containing primary uveal melanomas (UM). Using this technique, it was possible to obtain images of lysophosphatidylcholine (LPC) type lipid distribution that highlighted the tumour regions. Laser ablation inductively coupled plasma mass spectrometry images (LA-ICP-MS) performed on UM sections showed increases in copper within the tumour periphery and intratumoural zinc in tissue from patients with poor prognosis. These preliminary data indicate that multi-modal MSI has the potential to provide insights into the role of trace metals and cancer metastasis.

Corrigendum to “Modal Mass and Length of Mode Shapes in Structural Dynamics”

The literature about the mass associated with a certain mode, usually denoted as the modal mass, is sparse. Moreover, the units of the modal mass depend on the technique used to normalize the mode shapes, and its magnitude depends on the number of degrees of freedom (DOFs) used to discretize the model. This has led to a situation where the meaning of the modal mass and the length of the associated mode shape is not well understood. As a result, normally, both the modal mass and the length measure have no meaning as individual quantities, but only when they are combined in the frequency response function. In this paper, the problems of defining the modal mass and mode shape length are discussed, and solutions are found to define the quantities in such a way that they have individual physical meaning and can be estimated in an objective way.

Effect of Frequency Characteristics of Ground Motion on Response of Tuned Mass Damper Controlled Inelastic Concrete Frame

This paper investigates the performance of tuned mass damper (TMD) and dynamic behavior of TMD-controlled concrete structure considering the ground motion (GM) characteristics based on frequency content. The effectiveness of TMD in reducing the structural response and probability of collapse of the building frames are affected by the frequency characteristics of GMs. To attenuate the seismic vibration of the buildings, the TMD controlled building has been designed based on the modal analysis (modal frequencies and modal mass participation ratio). In this study, to investigate the performance of TMD, four different heights (i.e., 3, 5, 10, 20 stories) inelastic concrete moment-resisting frames equipped with TMDs are developed using an open-source finite element software. A series of numerical analyses have been conducted using sixty earthquakes classified into three categories corresponding to low, medium, and high-frequency characteristics of GMs. To evaluate the proposed strategy, peak lateral displacements, inter-story drift, and the probability of collapse using fragility analysis have been investigated through the structures equipped with and without TMD. The results appraise the effect of TMD and compare the seismic responses of earthquake frequency contents and the vibration control system of the inelastic building frames.