rodent glioma
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2021 ◽  
pp. molcanres.MCR-19-0995-E.2019
Author(s):  
Amelie Vezina ◽  
Monica Manglani ◽  
DreeAnna Morris ◽  
Brandon Foster ◽  
Matthew McCord ◽  
...  

2019 ◽  
Vol 9 (11) ◽  
pp. 303 ◽  
Author(s):  
Ricardo Vallejo ◽  
David C. Platt ◽  
Jonathan A. Rink ◽  
Marjorie A. Jones ◽  
Courtney A. Kelley ◽  
...  

Glial cells comprise the majority of cells in the central nervous system and exhibit diverse functions including the development of persistent neuropathic pain. While earlier theories have proposed that the applied electric field specifically affects neurons, it has been demonstrated that electrical stimulation (ES) of neural tissue modulates gene expression of the glial cells. This study examines the effect of ES on the expression of eight genes related to oxidative stress and neuroprotection in cultured rodent glioma cells. Concentric bipolar electrodes under seven different ES types were used to stimulate cells for 30 min in the presence and absence of extracellular glutamate. ES consisted of rectangular pulses at 50 Hz in varying proportions of anodic and cathodic phases. Real-time reverse-transcribed quantitative polymerase chain reaction was used to determine gene expression using the ∆∆Cq method. The results demonstrate that glutamate has a significant effect on gene expression in both stimulated and non-stimulated groups. Furthermore, stimulation parameters have differential effects on gene expression, both in the presence and absence of glutamate. ES has an effect on glial cell gene expression that is dependent on waveform composition. Optimization of ES therapy for chronic pain applications can be enhanced by this understanding.


Author(s):  
Thomas Linsenmann ◽  
Anna Jawork ◽  
Thomas Westermaier ◽  
Gy�rgy Homola ◽  
Camelia Monoranu ◽  
...  

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi218-vi218
Author(s):  
Xi Feng ◽  
Katherine Grue ◽  
Sharon Liu ◽  
Nalin Gupta ◽  
Susanna Rosi

2013 ◽  
Vol 27 (3) ◽  
pp. 253-260 ◽  
Author(s):  
Junzhong Xu ◽  
Ke Li ◽  
Zhongliang Zu ◽  
Xia Li ◽  
Daniel F. Gochberg ◽  
...  

2012 ◽  
Vol 17 (12) ◽  
pp. 126017 ◽  
Author(s):  
Abhishek Rege ◽  
Alan C. Seifert ◽  
Dan Schlattman ◽  
Yu Ouyang ◽  
Khan W. Li ◽  
...  

2012 ◽  
Vol 111 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Ananth K. Vellimana ◽  
Violette Renard Recinos ◽  
Lee Hwang ◽  
Kirk D. Fowers ◽  
Khan W. Li ◽  
...  
Keyword(s):  

Author(s):  
Hikmat Assi ◽  
Marianela Candolfi ◽  
Pedro R. Lowenstein ◽  
Maria G. Castro
Keyword(s):  

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