Synthesis, Spectroscopic, and Biological Assessments on Some New Rare Earth Metal Adrenaline Adducts

Adrenaline (Adr) reacts with chlorides of Y3+, Ce3+, Nd3+ and Sm3+ in methanol at 60 °C to yield metal ion adducts of definite composition. These compounds are characterized by elemental analyses, molar conductivity, UV-Vis., 1H–NMR, Raman laser, scanning electron microscopy, energy-dispersive X-ray spectroscopy (EDX), and mid infrared spectral measurement investigations. The adducts are found to have the formulae [Y2(Adr)2(H2O)8]Cl3.8H2O, [Ce(Adr)2(H2O)2]Cl3.10H2O, [Nd(Adr)2(H2O)2]Cl3.6H2O, and [Sm(Adr)2(H2O)2]Cl3.12H2O, respectively. The two phenolic groups of the catechol moiety are linked to central metal ions based on the infrared and Raman laser spectra. The new compounds were tested against five gram-positive and two-gram negative bacteria, in addition to two Aspergillus strains. Metal adducts were shown to have stronger antibacterial and antifungal properties than free adrenaline compounds.

The synthesis and metal binding chemistry of carbahemiporphyrazines with an electron withdrawing substituent

Benziphthalocyanine (bzpc) and dicarbahemiporphyrazine (dchp) are phthalocyanine analogs where one and two of the isoindoline units have been replaced with benzene rings. In this report, we present dchp and bzpc analogs 1 and 2 where CF3 groups have been placed on the 5-position of the benzene rings. Compounds 1 and 2 have identical structural features as their unmodified parent macrocycles, but some differences are observed in their metal adducts. Complex 1Ag shows few differences with the analogous dchp complex, but compounds 1Cu and 2Co exhibit reductions in M – C bond lengths arising from the electron withdrawing nature of the CF3 unit.