Comparative analysis of the secondary structure of non-histone chromatin proteins HMGB1 and HMGB2

The non-histone chromosomal proteins HMGB1 and HMGB2 were found in the cells of all studied eukaryotes. They are involved in cell decision and many biological processes such as replication, transcription, repair, etc. In this work, the secondary structure of the HMGB1 and HMGB2 proteins was studied by the circular dichroism method. It was shown that, despite the high homology between them, the secondary structure of these proteins is different. The revealed structural features, most likely, should influence their functions in the cell nucleus, in particular, the interaction with DNA and other proteins.