Spotlight influenza: Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, Belgium, 2015 to 2019

Background Seasonal influenza-like illness (ILI) affects millions of people yearly. Severe acute respiratory infections (SARI), mainly influenza, are a leading cause of hospitalisation and mortality. Increasing evidence indicates that non-influenza respiratory viruses (NIRV) also contribute to the burden of SARI. In Belgium, SARI surveillance by a network of sentinel hospitals has been ongoing since 2011. Aim We report the results of using in-house multiplex qPCR for the detection of a flexible panel of viruses in respiratory ILI and SARI samples and the estimated incidence rates of SARI associated with each virus. Methods We defined ILI as an illness with onset of fever and cough or dyspnoea. SARI was defined as an illness requiring hospitalisation with onset of fever and cough or dyspnoea within the previous 10 days. Samples were collected in four winter seasons and tested by multiplex qPCR for influenza virus and NIRV. Using catchment population estimates, we calculated incidence rates of SARI associated with each virus. Results One third of the SARI cases were positive for NIRV, reaching 49.4% among children younger than 15 years. In children younger than 5 years, incidence rates of NIRV-associated SARI were twice that of influenza (103.5 vs 57.6/100,000 person-months); co-infections with several NIRV, respiratory syncytial viruses, human metapneumoviruses and picornaviruses contributed most (33.1, 13.6, 15.8 and 18.2/100,000 person-months, respectively). Conclusion Early testing for NIRV could be beneficial to clinical management of SARI patients, especially in children younger than 5 years, for whom the burden of NIRV-associated disease exceeds that of influenza.

Towards the closure of Collar’s triangle by optical diagnostics

An experimental methodology is proposed for the study of aeroelastic systems. The approach locally evaluates the forces involved in Collar’s triangle, namely aerodynamic, elastic, and inertial forces. The position of flow tracers as well as of markers on the object surface is monitored by a volumetric PIV system. From the recorded images, the flow tracers and surfare markers are separated based on their optical characteristics. The resulting images are then analysed by Lagrangian particle tracking. The inertial and elastic forces are obtained solely analysing the motion and the deformation of the solid object, whereas the aerodynamic force distribution is obtained via the pressure-from-PIV technique. Experiments are conducted on a benchmark problem of fluid-structure interaction, featuring a flexible panel installed at the trailing edge of a cylinder. A polynomial fit of the markers’ positions is carried out to determine the panel’s instantaneous shape, from which the inertial and elastic forces are evaluated. The pressure loads on the panel are determined via solution of the Poisson equation for pressure, imposing adaptive boundary conditions that comply with the panel. The simultaneous measurement of the three forces allows to assess the equilibrium of forces, and in turn to close Collar’s triangle.

Noise reduction of Parallel barrier integrated with compact flexible panel device

Erection of parallel barriers to control environmental noise such as traffic noise and construction noise is commonly seen in community. Owing to the formation of multiple reflection waves between the parallel barriers, their performance may be worse than a single barrier. To improve the performance of parallel barriers, a small piece of flush-mounted panels backed by a slender cavity in an otherwise rigid wall of barriers is proposed. With the excitation of the incident wave from a sound source inside parallel barriers, the flexible panel vibrates and sound is radiated out to undergo acoustics interference with sound field between the parallel barriers so that the sound intensity in this space and diffraction wave at the barrier top edge is reduced over a broadband in the low-frequency regime. The use of the panel provides flexibility in controlling range of stopband with high insertion loss by varying mass and bending stiffness. A semi-analytical model for dealing with vibroacoustic coupling between the open cavity and vibrating panel in a two-dimensional configuration is established in order to understand the sound suppression mechanism within the shadow zone. With the optimal structural properties of the panel, the extra averaged insertion loss of about 5dB in the frequencies ranging from 50 to 1000 Hz is reached for the parallel barrier.

Frequency–Amplitude Relationship of a Nonlinear Symmetric Panel Absorber Mounted on a Flexible Wall

This study addresses the frequency–amplitude relationship of a nonlinear symmetric panel absorber mounted on a flexible wall. In many structural–acoustic works, only one flexible panel is considered in their models with symmetric configuration. There are very limited research investigations that focus on two flexible panels coupled with a cavity, particularly for nonlinear structural–acoustic problems. In practice, panel absorbers with symmetric configurations are common and usually mounted on a flexible wall. Thus, it should not be assumed that the wall is rigid. This study is the first work employing the weighted residual elliptic integral method for solving this problem, which involves the nonlinear multi-mode governing equations of two flexible panels coupled with a cavity. The reason for adopting the proposed solution method is that fewer nonlinear algebraic equations are generated. The results obtained from the proposed method and finite element method agree reasonably well with each other. The effects of some parameters such as vibration amplitude, cavity depth and thickness ratio, etc. are also investigated.

Two Actuation Methods for a Complete Morphing System Composed of a VGTM and a Compliant Parallel Mechanism

Presented in this paper is a complete morphing system consisting of a variable geometry truss manipulator (VGTM) that is fully covered by a flexible panel skin. Two approaches are studied for morphing control. The first one is to have the VGTM act as a driving mechanism and the flexible panels as a passive system. In this case, the VGTM is composed of active members and passive lockable members. It is shown that the morphing system can reach the desired shapes through intermediate steps. The second method is to have the flexible panels act as drivers and the VGTM as a passive supporting structure. In this case, the VGTM is only composed of passive lockable members. The morphing system can also achieve the desired poses through intermediate steps. The control strategies of the two methods are discussed along with kinematic analysis, a comparison study is conducted to show their pros and cons, and two prototypes are fabricated to verify the feasibility of two actuation methods.

Extending influenza surveillance to detect non-influenza respiratory viruses of public health relevance: analysis of surveillance data, 2015-2019, Belgium

BACKGROUNDSeasonal influenza-like illness (ILI) affects millions of people yearly. Severe acute respiratory infections (SARI), mainly caused by influenza, are a leading cause of hospitalisation and mortality. Increasing evidence indicates that non-influenza respiratory viruses (NIRVs) also contribute to the burden of SARI. In Belgium, SARI surveillance by a network of sentinel hospitals is ongoing since 2011.AIMHere, we report the results of using in-house multiplex PCRs for the detection of a flexible panel of viruses in respiratory ILI and SARI samples and the estimated incidence rates of SARI associated to each virus.METHODSILI was defined as an infection with onset of fever and cough or dyspnoea. SARI was defined as an infection requiring hospitalization with onset of fever and cough or dyspnoea within the previous 10 days. Samples were collected during four winter seasons and tested by multiplex RT-qPCRs for influenza virus and NIRVs. Using catchment population estimates, incidence rates of SARI associated to each virus were calculated.RESULTSOne third of the SARI cases were positive for NIRVs, reaching 49.4% among children under fifteen. In children under five, incidence rates of NIRV-associated SARI were double that of influenza (103.4 versus 57.6 per 100000 person-months), with NIRV co-infections, respiratory syncytial viruses, human metapneumoviruses and picornaviruses contributing the most (33.1, 13.6, 15.8 and 18.2 per 100000 person-months, respectively).CONCLUSIONEarly testing for NIRVs could be beneficial to clinical management of SARI patients, especially in children under five, for whom the burden of NIRV-associated disease exceeds that of influenza.