“Reading” a new chapter in protozoan parasite transcriptional regulation

Protozoan parasites continue to cause a significant health and economic burden worldwide. As infectious organisms, they pose unique and difficult challenges due to a level of conservation of critical eukaryotic cellular pathways with their hosts. Gene regulation has been pinpointed as an essential pathway with enough divergence to warrant investigation into therapeutically targeting. Examination of human parasites such as Plasmodium falciparum, Toxoplasma gondii, and kinetoplastids have revealed that epigenetic mechanisms play a key role in their gene regulation. The enzymes involved in adding and removing epigenetic posttranslational modifications (PTMs) have historically been the focus of study. However, the reader proteins that recognize and bind PTMs, initiating recruitment of chromatin-modifying and transcription complexes, are now being realized for their critical role in regulation and their potential as drug targets. In this review, we highlight the current knowledge on epigenetic reader proteins in model parasitic protozoa, focusing on the histone acyl- and methyl-reading domains. With this knowledge base, we compare differences between medically relevant parasites, discuss conceivable functions of these understudied proteins, indicate gaps in knowledge, and provide current progress in drug development.

A CONFIGURABLE MINING APPROACH FOR LEARNING SERVICES CUSTOMIZATION

There is no doubt that this age is the age of data and technology. Moreover, there is tremendous development in all fields. The personalized material is a good approach in the different fields. It provides a fit material that matches the styles of readers. It supports readers in various reading domains. This research paper aims to support students in the educational system. Additionally, the research paper designs to increase education values for students. Furthermore, the research paper builds the smart appropriate materials through Egyptian Knowledge Banking (EKB) based on the learner question. The Egyptian Knowledge Bank (EKB) is a rich platform for data. The research paper is implemented in the faculty of Commerce and Business Administration, Business Information System program (BIS) at Helwan University, Egypt.

Using English Language Arts to Teach a Song

Music and reading domains require similar auditory processing skills. Students employ these skills when learning a new song through an oral/aural or rote-teaching approach. In this article, I review literature on the effectiveness of immersion and phrase-by-phrase approaches for teaching a song with or without words. Then, using an amusing analogy, I suggest a process for using the English language arts to teach a song using a rote approach. Two lessons are described that include prompts to aid teachers in analyzing songs to teach music through language.