retinal antigen
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Author(s):  
Keitaro Hase ◽  
Kenichi Namba ◽  
Haruka Wada ◽  
Hyuma Tsuji ◽  
Aoi Maeda ◽  
...  

2009 ◽  
Vol 183 (2) ◽  
pp. 814-822 ◽  
Author(s):  
Dale S. Gregerson ◽  
Neal D. Heuss ◽  
Ute Lehmann ◽  
Scott W. McPherson

2008 ◽  
Vol 40 (3-4) ◽  
pp. 154-159 ◽  
Author(s):  
Dale S. Gregerson ◽  
Neal D. Heuss ◽  
Ute Lehmann ◽  
Scott W. McPherson

2007 ◽  
Vol 179 (8) ◽  
pp. 5146-5158 ◽  
Author(s):  
Phyllis B. Silver ◽  
Rajeev K. Agarwal ◽  
Shao-Bo Su ◽  
Isabelle Suffia ◽  
Rafael S. Grajewski ◽  
...  

2007 ◽  
Vol 110 (2) ◽  
pp. 269-271 ◽  
Author(s):  
Maria Ejma ◽  
Marta Misiuk-Hojło ◽  
Wojciech A. Gorczyca ◽  
Ryszard Podemski ◽  
Stanisław Szymaniec ◽  
...  

2003 ◽  
Vol 198 (11) ◽  
pp. 1665-1676 ◽  
Author(s):  
Dody Avichezer ◽  
Rafael S. Grajewski ◽  
Chi-Chao Chan ◽  
Mary J. Mattapallil ◽  
Phyllis B. Silver ◽  
...  

Immunologically privileged retinal antigens can serve as targets of experimental autoimmune uveitis (EAU), a model for human uveitis. The tolerance status of susceptible strains, whose target antigen is not expressed in the thymus at detectable levels, is unclear. Here, we address this issue directly by analyzing the consequences of genetic deficiency versus sufficiency of a uveitogenic retinal antigen, interphotoreceptor retinoid-binding protein (IRBP). IRBP-knockout (KO) and wild-type (WT) mice on a highly EAU-susceptible background were challenged with IRBP. The KO mice had greatly elevated responses to IRBP, an altered recognition of IRBP epitopes, and their primed T cells induced exacerbated disease in WT recipients. Ultrasensitive immunohistochemical staining visualized sparse IRBP-positive cells, undetectable by conventional assays, in thymi of WT (but not of KO) mice. IRBP message was PCR amplified from these cells after microdissection. Thymus transplantation between KO and WT hosts demonstrated that this level of expression is functionally relevant and sets the threshold of immune (and autoimmune) reactivity. Namely, KO recipients of WT thymi generated reduced IRBP-specific responses, and WT recipients of KO thymi developed enhanced responses and a highly exacerbated disease. Repertoire culling and thymus-dependent CD25+ T cells were implicated in this effect. Thus, uveitis-susceptible individuals display a detectable and functionally significant tolerance to their target antigen, in which central mechanisms play a prominent role.


2003 ◽  
Vol 44 (11) ◽  
pp. 4805 ◽  
Author(s):  
Hui Xu ◽  
Phyllis B. Silver ◽  
Teresa K. Tarrant ◽  
Chi-Chao Chan ◽  
Rachel R. Caspi

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