Intra-Site Structure of the Early Ahmarian Site of Al-Ansab 1, AH 1 (Jordan)

The Early Ahmarian represents an Early Upper Palaeolithic cultural unit, which spans throughout the Levant to the Sinai Peninsula. At least 40 sites belong to this unit. Both open-air and cave sites provide different amounts of archaeological material at various spatial resolutions. The team of the Collaborative Research Centre 806 “Our Way to Europe” excavated the site of Al-Ansab 1, Wadi Sabra, since 2009. The site provides one of the largest lithic assemblages of the Early Ahmarian. Analysis of intra-site distributions and patterns has been conducted for a small number of sites, providing scarce information on the spatial makeup of Early Ahmarian occupation layers. The internal structure testifies to repeated settlement without task specialisation. While this has been described for the sites on the Sinai Peninsula, the situation has been unclear for locations placed in the escarpments of the Transjordanian Highlands. At Al-Ansab 1, we can observe the repeated, relatively ephemeral occupation of a specific location in the Wadi Sabra for the execution of various tasks such as processing of faunal elements and raw material exploitation. Our results correlate to a pattern of mobility observable at other Early Ahmarian sites such as Abu Noshra II. These sites are usually attributed to relatively small and highly mobile bands of hunter-gatherers. Analysing these patterns of intra-site and regional spatial behaviour in the context of environmental patterning highlights potential external drivers to the expression of human occupation at sites such as Al-Ansab 1, archaeological horizon 1.

THREE-DIMENSIONAL COMPUTATIONAL MODEL OF EARLY UPPER LIMB DEVELOPMENT

Limb development begins during embryogenesis when a series of biochemical interactions are triggered between a particular region of the mesoderm and the ectoderm. These processes affect the morphogenesis and growth of bones, joints, and all the other constituent elements of limbs; nevertheless, how the biochemical regulation affects mesenchymal condensation is not entirely clear. In this study, a three-dimensional computational model is designed to predict the appearance and location of the mesenchymal condensation in the stylopod and zeugopod; the biochemical events were described with reaction–diffusion equations that were solved using the finite elements method. The result of the gene expression in our model was consistent with the one reported in literature; the obtained patterns of Fgf8, Fgf10, and Wnt3a can predict the shape of the mesenchymal condensation of early upper limb development; the simple diffusive patterns of molecules were suitable to explain the areas where sox9 is expressed. Furthermore, our results suggest that the expression of Tgf-[Formula: see text] in the upper limb could be due to the inhibition of retinoic acid. These results suggest the importance of building computational scenarios where pathologies may be comprehensively examined.

Utilization of Ultrasonic Image Characteristics Combined with Endoscopic Detection on the Basis of Artificial Intelligence Algorithm in Diagnosis of Early Upper Gastrointestinal Cancer

The aim of this study was to evaluate the diagnostic value of artificial intelligence algorithm combined with ultrasound endoscopy in early esophageal cancer and precancerous lesions by comparing the examination of conventional endoscopy and artificial intelligence algorithm combined with ultrasound endoscopy, and by comparing the real-time diagnosis of endoscopy and the ultrasonic image characteristics of artificial intelligence algorithm combined with endoscopic detection and pathological results. 120 cases were selected. According to the inclusion and exclusion criteria, 80 patients who met the criteria were selected and randomly divided into two groups: endoscopic examination combined with ultrasound imaging based on intelligent algorithm processing (cascade region-convolutional neural network (Cascade RCNN) model algorithm group) and simple use of endoscopy group (control group). This study shows that the ultrasonic image of artificial intelligence algorithm is effective, and the detection performance is better than that of endoscopic detection. The results are close to the gold standard of doctor recognition, and the detection time is greatly shortened, and the recognition time is shortened by 71 frames per second. Compared with the traditional convolutional neural network (CNN) algorithm, the accuracy and recall of image analysis and segmentation using feature pyramid network are increased. The detection rates of CNN model, Cascade RCNN model, and endoscopic detection alone in early esophageal cancer and precancerous lesions are 56.3% (45/80), 88.8% (71/80), and 44.1% (35/80), respectively. The detection rate of Cascade RCNN model and CNN model was higher than that of endoscopy alone, and the difference was statistically significant ( P < 0.05 ). The sensitivity, specificity, positive predictive value, and negative predictive value of Cascade RCNN model were higher than those of CNN model, which was close to the gold standard for physician identification. This provided a reference basis for endoscopic ultrasound identification of early upper gastrointestinal cancer or other gastrointestinal cancers.

Evidence of the use of soft footwear in the Gravettian cave of Cussac (Dordogne, France)

Humans appear to have regularly worn footwear since at least the Early Upper Palaeolithic. However, due to the perishable nature of footwear, the archaeological record of its presence during the Pleistocene is poor. While footwear would have played an essential role in protecting the foot, it could also have been used as ornamentation and/or as a social marker. Footprints may provide the most relevant insight regarding the origin and function of footwear. Here we report the discovery of footprints in Cussac Cave (southwest France) at 28–31 ka cal BP and the results of a multi-focal approach, including experimentation, that demonstrate that Gravettian people most likely wore footwear while moving through the cave. These singular footprints would constitute one of the oldest cases of indirect evidence for this unusual practice in decorated Palaeolithic caves and reinforce the exceptional nature of Cussac already attested by the presence of monumental engravings and funerary deposits.

Between two worlds: Cova Eirós and the Middle-Upper Palaeolithic transition in NW Iberia

Iberia, a natural cul-de-sac peninsula, plays a major role in the study of the Neanderthals demise and its eventual relationship with the spread of Anatomically Modern Humans (AMH) in Europe. The site of Cova Eirós (Galicia, Spain), located in NW Iberia, contains Middle and Upper Palaeolithic levels, based on the cultural remains recovered at the site. No human remains directly associated with those levels were discovered yet. The available radiocarbon dates from the levels 2 (c. 35 ka cal BP, Early Upper Paleolithic) and 3 (c. 41 ka cal BP, Late Middle Paleolithic), point to a late survival of Neanderthal groups in North Iberia and to a relative quick arrival of the AMH, c. 35-36 ka cal BP, with respect to other territories of the Iberian Peninsula. The archaeological record shows clear differences between the Middle and the Upper Palaeolithic occupations, regarding raw-material acquisition, lithic technology and subsistence strategies. The location of Cova Eirós in the westernmost margin of the Cantabrian Rim and in the Atlantic Façade, makes this site a key place to understand the spread of the first AMH and the progressive demise of Neanderthal populations.

Revisiting the Middle and Upper Palaeolithic archaeology of Gruta do Caldeirão (Tomar, Portugal)

Gruta do Caldeirão features a c. 6 m-thick archaeological stratification capped by Holocene layers ABC-D and Ea, which overlie layer Eb, a deposit of Magdalenian age that underwent significant disturbance, intrusion, and component mixing caused by funerary use of the cave during the Early Neolithic. Here, we provide an updated overview of the stratigraphy and archaeological content of the underlying Pleistocene succession, whose chronology we refine using radiocarbon and single-grain optically stimulated luminescence dating. We find a high degree of stratigraphic integrity. Dating anomalies exist in association with the succession’s two major discontinuities: between layer Eb and Upper Solutrean layer Fa, and between Early Upper Palaeolithic layer K and Middle Palaeolithic layer L. Mostly, the anomalies consist of older-than-expected radiocarbon ages and can be explained by bioturbation and palimpsest-forming sedimentation hiatuses. Combined with palaeoenvironmental inferences derived from magnetic susceptibility analyses, the dating shows that sedimentation rates varied in tandem with the oscillations in global climate revealed by the Greenland oxygen isotope record. A steep increase in sedimentation rate is observed through the Last Glacial Maximum, resulting in a c. 1.5 m-thick accumulation containing conspicuous remains of occupation by people of the Solutrean technocomplex, whose traditional subdivision is corroborated: the index fossils appear in the expected stratigraphic order; the diagnostics of the Protosolutrean and the Lower Solutrean predate 24,000 years ago; and the constraints on the Upper Solutrean place it after Greenland Interstadial 2.2. (23,220–23,340 years ago). Human usage of the site during the Early Upper and the Middle Palaeolithic is episodic and low-intensity: stone tools are few, and the faunal remains relate to carnivore activity. The Middle Palaeolithic is found to persist beyond 39,000 years ago, at least three millennia longer than in the Franco-Cantabrian region. This conclusion is upheld by Bayesian modelling and stands even if the radiocarbon ages for the Middle Palaeolithic levels are removed from consideration (on account of observed inversions and the method’s potential for underestimation when used close to its limit of applicability). A number of localities in Spain and Portugal reveal a similar persistence pattern. The key evidence comes from high-resolution fluviatile contexts spared by the site formation issues that our study of Caldeirão brings to light—palimpsest formation, post-depositional disturbance, and erosion. These processes. are ubiquitous in the cave and rock-shelter sites of Iberia, reflecting the impact on karst archives of the variation in climate and environments that occurred through the Upper Pleistocene, and especially at two key points in time: between 37,000 and 42,000 years ago, and after the Last Glacial Maximum. Such empirical difficulties go a long way towards explaining the controversies surrounding the associated cultural transitions: from the Middle to the Upper Palaeolithic, and from the Solutrean to the Magdalenian. Alongside potential dating error caused by incomplete decontamination, proper consideration of sample association issues is required if we are ever to fully understand what happened with the human settlement of Iberia during these critical intervals, and especially so with regards to the fate of Iberia’s last Neandertal populations.

“Poor” archeological levels not to be forgotten: units of Middle and early Upper Magdalenian age in El Mirón Cave (Ramales de la Victoria, Cantabria, Spain)

This succinct contribution focuses on description and preliminary interpretation of “minor” occupations of the large, strategically located El Mirón Cave on the edge of the Cantabrian Cordillera in eastern Cantabria (Spain) during the Middle and early Upper Magalenian that followed upon the massive, culturally rich, faunally dense, functionally complex deposits of the Initial and Lower Magdalenian. The ten levels analyzed here date to the Late Glacial, c. 15.5-12.5 uncal kya BP. At a time when the classic Middle Magdalenian of the nearby French Pyrenees developed and major residential sites with clear social links to it (via the key site of Isturitz) were occupied in the lowland coastal zone of Cantabria and Asturias (e.g. La Garma, Llonín, La Viña), El Mirón had reverted for the most part to the role of a short-term, special-purpose, perhaps logistical campsite, rather than as a long-term, large-scale hub residential base. It is tempting (and indeed traditional) to focus on levels with large numbers of lithic and osseous artifacts, as well as works of portable art and personal ornaments, which are so characteristic of the most famous Magdalenian occupations. However, in hunter-gatherer subsistence systems, the “minor” locations played a significant role in the human exploitation of territories (especially ones with such complex, high relief as Cantabrian Spain). The levels in question here include some that can be interpreted as hunting camps (suggested by high percentages of worked and unworked bladelets and some antler points within the small assemblages), partially reminiscent of the use to which the cave may have been put during pre-Initial Magdalenian times, notably during the Solutrean, which was relatively rich in stone points.