Regulation Awareness and Experience of Additional Monitoring among Healthcare Professionals in Finland

Background: Challenges in post-marketing adverse event reporting are generally recognized. To enhance reporting, the concept of additional monitoring was introduced in 2012. Additional monitoring aims to enhance reporting of adverse events (AE) for medicines for which the clinical evidence base is less well developed. Purpose: The purpose was to get a deeper understanding of the underlying reasons why additional monitoring has not increased AE reporting as much as initially hoped. We examined how healthcare professionals (HCPs) in Finland perceive additional monitoring, why they do or do not report AEs more readily for these medicines and how they interact with patients treated with additionally monitored medicines. Methods: An anonymous, open questionnaire was developed and made available online at the e-form portal of University of Helsinki. Physicians, nurses, and pharmacists were invited to complete the questionnaire via their respective trade or area unions. Content analysis of answers to open-ended questions was performed by two independent coders. Results: Pharmacists have the best understanding about additional monitoring but at the same time do not recognize their role in enhancing monitoring. Only 40% of HCPs working with patients knows always or often if a specific medicine is additionally monitored. Half (53%) of HCPs do not tell or tell only rarely patients about additional monitoring. 18% of HCPs reported having received additional monitoring training whereas 29% had received general AE reporting training. AE reporting was more common among HCPs who had received training. Conclusions: Additional monitoring awareness among HCPs and patients should be increased by organizing regular educational events and making additional monitoring more visible. Educational events should emphasize the significance additional monitoring has on patient safety and promote a reporting culture among HCPs.

Advanced fluid models for resonant online oil condition monitoring systems

Two main topics are presented in this work which enable more efficient use of oil condition monitoring systems based on resonant fluid sensing. A new fluid model for a recently introduced compact measurement unit for oil condition monitoring based on simultaneous measurement of viscosity and density is discussed. It is shown that a new fluid model allows achieving higher accuracies, which is demonstrated by comparison to earlier models. The second topic deals with measuring fluid parameters over varying temperatures and thus providing additional monitoring parameters and enhanced data consistency. We propose an alternative representation of the Vogel model using transformed parameters having a clear physical meaning and which are more stable in presence of measurement noise.

▼Romosozumab for osteoporosis

Generic name: RomosozumabBrand name: EvenityFormulation: 105 mg solution for injection in a pre-filled penMarket Authorisation holder: UCB Pharma LimitedIndication: treatment of severe osteoporosis in postmenopausal women at high risk of fractureDose: 210 mg romosozumab (administered as two subcutaneous injections of 105 mg each) once a month for 12 months. It is recommended that patients begin antiresorptive therapy after completing treatment with romosozumab.Cost: £427.75 for two pre-filled pens each containing 105 mg romosozumabClassification: Prescription only medicine (POM) subject to additional monitoring (▼)

Improved control and monitor two different PLC using LabVIEW and NI-OPC server

<span>This paper proposes an improved control and monitors between two different PLCs, the Mitsubishi, and Omron. The main advantage is interoperability and communication between both PLC. The use of NI OPC server as the software interface reached interoperability and communication. There were developed two field applications to test interoperability. Laboratory virtual instrument engineering workbench (LabVIEW) uses as the software application for creating the user interface to control and monitor. This improvement show OPC server technology solves data compatibility issue between different driver controller’s and reducing development cost. Regardless of whether there are more than two different PLCs, it's enough to use the NI OPC server. So the benefit of the NI OPC server is not limited to two types of PLC used right now but can also use the other manufacturers. Besides, the improvement of the previous study is the use of the LabVIEW makes data from the OPC server displayed more realistic. The use of LabVIEW allows additional monitoring functions, one of which is LabVIEW vision. Data utilization becomes more flexible, and so it can use for more complex purposes. It is envisaged that this is very useful for Integrator engineer to implement this method in industrial automation</span>

A multi-site, year-round turbulence microstructure atlas for the deep perialpine Lake Garda

A multi-site, year-round dataset comprising a total of 606 high-resolution turbulence microstructure profiles of shear and temperature gradient in the upper 100 m depth is made available for Lake Garda (Italy). Concurrent meteorological data were measured from the fieldwork boat at the location of the turbulence measurements. During the fieldwork campaign (March 2017-June 2018), four different sites were sampled on a monthly basis, following a standardized protocol in terms of time-of-day and locations of the measurements. Additional monitoring activity included a 24-h campaign and sampling at other sites. Turbulence quantities were estimated, quality-checked, and merged with water quality and meteorological data to produce a unique turbulence atlas for a lake. The dataset is open to a wide range of possible applications, including research on the variability of turbulent mixing across seasons and sites (demersal vs pelagic zones) and driven by different factors (lake-valley breezes vs buoyancy-driven convection), validation of hydrodynamic lake models, as well as technical studies on the use of shear and temperature microstructure sensors.

Assessment of Parasitological Water Quality from House Kitchens and Desalination Plants Filters in Gaza Strip

This study was conducted to assess parasitological water quality from house kitchens and desalination plants filters in Gaza Strip. A total of 420 samples were collected from the five Governorates of Gaza Strip; 300 samples were collected from 100 houses and 120 samples were collected from 40 desalination plants. All samples were examined using direct wet mount, acid fast stain and Polymerase Chain Reaction. The randomlly distributed questionnaire included questions regarding economic and social factors, water sources, reported symptoms and public health. Results revealed that only Cryptosporidium spp. oocysts were detected in eight of drinking water samples 1.9% (8/420). Eight samples were positive when using acid-fast stain (Cryptosporidium spp.) in Reverse osmosis (RO) house filters. Using PCR to identify Cryptosporidium spp. (C. parvum and C. hominis), only one sample (0.24%) was positive for C. parvum while there are no positive samples for C. hominis. The occurrence of Cryptosporidium oocysts in the investigated water supplies may require the water utilities and water authorities in Gaza Strip to apply additional monitoring, treatment and/or watershed controls for safe drinking water.

Individual and Additive Effects of Insecticide and Mating Disruption in Integrated Management of Navel Orangeworm in Almonds

Damage from Amyelois transitella, a key pest of almonds in California, is managed by destruction of overwintering hosts, timely harvest, and insecticides. Mating disruption has been an increasingly frequent addition to these management tools. Efficacy of mating disruption for control of navel orangeworm damage has been demonstrated in experiments that included control plots not treated with either mating disruption or insecticide. However, the navel orangeworm flies much farther than many orchard pests, so large plots of an expensive crop are required for such research. A large almond orchard was subdivided into replicate blocks of 96 to 224 ha and used to compare harvest damage from navel orangeworm in almonds treated with both mating disruption and insecticide, or with either alone. Regression of navel orangeworm damage in researcher-collected harvest samples from the interior and center of management blocks on damage in huller samples found good correlation for both and supported previous assumptions that huller samples underreport navel orangeworm damage. Blocks treated with both mating disruption and insecticide had lower damage than those treated with either alone in 9 of the 10 years examined. Use of insecticide had a stronger impact than doubling the dispenser rate from 2.5 to 5 per ha, and long-term comparisons of relative navel orangeworm damage to earlier- and later-harvested varieties revealed greater variation than previously demonstrated. These findings are an economically important confirmation of trade-offs in economic management of this critical pest. Additional monitoring tools and research tactics will be necessary to fulfill the potential of mating disruption to reduce insecticide use for navel orangeworm.

Applicability of a Commercially Available Active Extremity Dose-Rate Meter to Eye Lens Dose Monitoring

A commercially available active extremity dosemeter is a promising candidate for medical staff aid individual monitoring of the eye lens. We investigated the applicability of the newly developed active extremity dosemeter, which uses a low-energy photon probe, to eye lens dose monitoring by performing a complete characterization of the dosemeters. Performance tests revealed that the active extremity dosemeter would overestimate personal dose equivalent, Hp(3), when the probe is worn close to the lens of the eye of a medial worker without any improvement in the response. Introducing an appropriate filter into the probe for low-energy photon has proven to improve the response. The dosemeter then satisfies the criteria of the personal dosemeter for eye lens dosimetry and can be applicable to individual monitoring of eye lens dose. This article also discusses the applicability of the dosemeter to area monitoring for decision making regarding additional monitoring of the eye lens and the extremities.

Luteal phase pregnancy after mirena coil insertion for intrauterine septum resection

This report is of an unusual case of an intrauterine singleton pregnancy with a Mirena Coil (IUS) in situ following an elective hysteroscopic intrauterine septum resection for treatment of primary subfertility in a 27-year-old female. The patient elected to continue with the pregnancy and underwent additional monitoring via ultrasound. A caesarean section was undertaken at 39-weeks gestation and a healthy male infant was born. The Mirena coil was recovered intraoperative and was visualised in the placental membranes. Pregnancy occurring with Mirena coil insertion as an adjunct to hysteroscopic septum resection in our case is an unusual clinical scenario with no management recommendations and limited recorded outcomes. Therefore, this case demonstrates potential management of such a case and learning points for intrauterine septum excision in the context of primary subfertility.