A simple cognitive task intervention to prevent intrusive memories after trauma in patients in the Emergency Department: A randomized controlled trial terminated due to COVID-19

Objective This randomised controlled trial (RCT) aimed to investigate the effects of a simple cognitive task intervention on intrusive memories ("flashbacks") and associated symptoms following a traumatic event. Patients presenting to a Swedish emergency department (ED) soon after a traumatic event were randomly allocated (1:1) to the simple cognitive task intervention (memory cue + mental rotation instructions + computer game "Tetris" for at least 20 min) or control (podcast, similar time). We planned follow-ups at one-week, 1-month, and where possible, 3- and 6-months post-trauma. Anticipated enrolment was N = 148. Results The RCT was terminated prematurely after recruiting N = 16 participants. The COVID-19 pandemic prevented recruitment/testing in the ED because: (i) the study required face-to-face contact between participants, psychology researchers, ED staff, and patients, incurring risk of virus transmission; (ii) the host ED site received COVID-19 patients; and (iii) reduced flow of patients otherwise presenting to the ED in non-pandemic conditions (e.g. after trauma). We report on delivery of study procedures, recruitment, treatment adherence, outcome completion (primary outcome: number of intrusive memories during week 5), attrition, and limitations. The information presented and limitations may enable our group and others to learn from this terminated study. Trial registration ClinicalTrials.gov: NCT04185155 (04-12-2019)

Anticipating Peer Ranking Causes Hormonal Adaptations That Benefit Cognitive Performance

Performance ranking is common across a range of professional and recreational domains. Even when it has no economic consequences but does order people in terms of their social standing, anticipating such performance ranking may affect how people feel and perform. We examined this possibility by asking human subjects to execute a simple cognitive task while anticipating their performance being ranked by an outside evaluator. We measured baseline and postperformance levels of testosterone and cortisol. We find that (1) anticipating performance ranking reduces testosterone and increases cortisol, (2) both these hormonal responses benefit cognitive performance, which explains why (3) anticipation of being ranked by a peer increases cognitive performance.

More than Means: Characterizing Individual Differences in Pupillary Dilations

This study sought to characterize individual differences in pupillary dilations during a simple cognitive task. Eighty-four Navy and Marine Corps student pilots performed a digit memory recall test while their pupillary data were recorded. Results showed that peak pupil sizes significantly increased with difficulty of the memory task, however variability in pupillary dilations was substantial, with only 51% of individuals’ data corresponding with the aggregate results and dilations varying between participants by as much as 1 millimeter. The analyses presented in this paper illustrate the large individual variability that exists in pupil data, between individuals and even within individuals on a trial by trial basis. This work serves as a benchmark for understanding variability in pupillary dilations and encourages follow on work to explore casual mechanisms of differences in pupil dilations across individuals, especially before using pupil data for applied purposes.

Automatic Responses to Acoustically Rough Intervals: Evidence from a Word Evaluation task

The aim of the present study is to determine which acoustic components of harmonic consonance and dissonance influence automatic responses in a simple cognitive task. In a series of experiments, ten musical interval pairs were used to measure the influence of acoustic roughness and harmonicity on response times in an affective priming task conducted online. There was a significant correlation between the difference of roughness for each pair of intervals and a response time index. Harmonicity did not influence response times on the cognitive task. More detailed analysis suggests that the presence of priming in intervals is binary: in the negative primes that create congruency effects the intervals’ fundamentals and overtones coincide within the same equivalent rectangular bandwidth (i.e. the minor and major seconds). Intervals that fall outside this equivalent rectangular bandwidth do not elicit priming effects, regardless of their dissonance or cultural conventions of negative affect. The results are discussed in the context of recent developments in consonance/dissonance research and vocal similarity.

Balance Dysfunction in Parkinson’s Disease: The Role of Posturography in Developing a Rehabilitation Program

Balance dysfunction (BD) in Parkinson’s disease (PD) is a disabling symptom, difficult to treat and predisposing to falls. The dopaminergic drugs or deep brain stimulation does not always provide significant improvements of BD and rehabilitative approaches have also failed to restore this condition. In this study, we investigated the suitability of quantitative posturographic indicators to early identify patients that could develop disabling BD. Parkinsonian patients not complaining of a subjective BD and controls were tested using a posturographic platform (PP) with open eyes (OE) and performing a simple cognitive task [counting (OEC)]. We found that patients show higher values of total standard deviation (SD) of body sway and along the medio-lateral (ML) axis during OE condition. Furthermore, total and ML SD of body sway during OE condition and total SD of body sway with OEC were higher than controls also in a subgroup of patients with normal Berg Balance Scale. We conclude that BD in Parkinsonian patients can be discovered before its appearance using a PP and that these data may allow developing specific rehabilitative treatment to prevent or delay their onset.