Microwave-assisted organo-catalyzed C-C and C-X (heteroatom) bond-forming reactions-An overview

: Organocatalysis defines small organic molecules exclusively containing carbon, hydrogen, oxygen, nitrogen, sulfur and phosphorous atom to speed-up the chemical reactions. Researcher demonstrated large area of applications in various organic transformations catalyzed by the organocatalysts, due to their less moisture sensitivity and air, easy abundance, less polluting, not interfere with the final product and inexpensive. This highlights high demand and direct benefits in the pharmaceutical intermediate and fine chemical manufacture compared to other conventional transition metal and enzyme catalysts. This review article intends to compile literature reported application of the microwave accelerated organocatalyzed carbon-carbon and carbon–heteroatom bond formation reactions reported in the literature.

Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications

Continuous flow chemistry is becoming an established technology platform that finds frequent application in industrial chemical manufacture with support and endorsements by the FDA for pharmaceuticals. Amongst the various advantages that are commonly cited for flow chemistry over batch processing, sustainability continues to require further advances and joint efforts by chemists and chemical engineers in both academia and industry. This short review highlights developments within the last 5 years that positively impact on the green credentials associated with flow chemistry, specifically when applied to the preparation of pharmaceuticals. An industrial perspective on current challenges is provided to whet discussion and stimulate further investment towards achieving greener modern synthetic technologies.

Process intensification of ozonolysis reactions using dedicated microstructured reactors

Ozonolysis reactions are generally high-yielding, highly selective, and sustainable processes, especially when performed in green solvents. However, ozonolysis is underutilized in organic synthesis and chemical manufacture due to the safety...

Electrocatalytic hydrogenation of lignin monomer to methoxy-cyclohexanes with a high faradaic efficiency

Developing efficient renewable electrocatalytic processes for chemical manufacture is of commercial interest, especially from the biomass-derived feedstock. Selective electrocatalytic hydrogenation (ECH) of biomass-derived lignin monomers to high-value oxygen-functional compounds is...

Advances in biological conversion technologies: new opportunities for reaction engineering

Reaction engineering needs to embrace biological conversion technologies, on the road to identify more sustainable routes for chemical manufacture.

FUNCTIONAL MODELING OF THE PROCESS OF CHOOSING THE BEST AVAILABLE TECHNIQUE

Due to the relevance of the problem of implementation of the Best Available Techniques (BAT) in the chemical industry of the Russian Federation it is necessary to develop a scientifically defensible transition process to BAT for chemical manufactures. For this purpose, the functional modeling methodology was used in the graphical notation IDEF0 standardized in the Russian Federation. The production process for the transition of a chemical manufacture to BAT was described as a hierarchical structure represented as a diagram consisting of functional blocks and arcs that connect them. First, the simulation object was represented as a single block with boundary arrows, which show how the simulated process is related to the environment. Then it was sequentially decomposed into diagrams of a lower level, i.e., stepwise hierarchical decomposition of the top-level context diagram was performed, which resulted in a set of interrelated diagrams that describe the processes and relationships between them and the environment. This allows us to clearly establish the order of actions that are performed at each stage of the transfer of chemical manufacture to BAT.