This chapter explores the role of a musical pattern, the Romanesca schema, as a signifier of spiritual meanings in opera. It addresses the relationship between the Romanesca and the hymn topic and argues that the schema, semantically empty in its origins, acquired in the late eighteenth century connotations of ceremony, solemnity, alterity, and even transcendence. Several vignettes from operas by Haydn and Mozart illustrate how composers deployed the pattern in scenes depicting worship, prayers, and ritual actions. Beethoven’s Fidelio occupies the final section, a case study that shows the Romanesca interacting with other elements of the musical structure for expressive purposes. The chapter provides a novel interpretation of certain moments of the opera, suggesting that Beethoven relied on the sacred implications of the Romanesca—arguably available to historical listeners—to intensify the spiritual dimension of the drama.