Design and Conduct of Clinical Studies by Integration of Quality by Design (QbD) into Quality Management System (QMS) - A Pragmatic Approach

Quality is a prerequisite during entire drug development cycle. Clinical studies are required to prove effectiveness of experiment drug and to evaluate its safety profile in humans. To have a smooth design and conduct of clinical studies; Quality-by-Design (QbD) approach can be integrated with Quality Management System (QMS) to ensure the end-to-end quality optimization. Quality by Design is not widely used currently in clinical research.

Endoscopic Yield in Anemia of Chronic Disease: A Single-Center Retrospective Study of U.S. Veteran Population

Goals: The aim of the study was to evaluate endoscopic yield in patients with Anemia of Chronic Disease (ACD) who had no Gastrointestinal (GI) symptoms. We analyzed the impact of laboratory and clinical variables on endoscopic yield in this cohort.

The Static Air-Mattress-Inflation Pressure and Nosocomial Pressure Injury-An Innovation in Preventing Pressure Injuries

Background: Pressure injuries are said to be nosocomial when they occur after twenty-four (24) hours on admission. Prevention of pressure injuries in high-risk patients such as those with spinal cord injury, the unconscious, and those with femoral neck fracture is essential. The static air-mattress is one of the pressure relieving devices used to prevent pressure injury in low resource countries. However, some patients develop pressure injuries despite being nursed on the air-mattress. The inflation pressure of the static air-mattress is usually not measured, thus is unknown. Therefore, the air-mattress may be over-inflated or under-inflated and ineffective in the prevention of pressure injury.

A Review of Post-Burn Contracture Release Procedures at the National Orthopaedic Hospital, Enugu

Background: Contracture release surgeries are done to correct functional impairment, pain or discomfort, recurrent ulceration and cosmetic challenges associated with contractures across joints and mobile structures such as the eyelids.

A Preliminary Study on Various Types of 4-Aminoquinolines for Pre- or PostExposure Prophylaxis and for Treatment in Severe COVID-19

Background: LiveWell Initiative LWI is a self-funded nonprofit social enterprise which thrives on innovation.