The Adaptive Complex Enterprise framework presented provides a basis for integrating many related areas of research into a services discipline. We have shown the framework is widely applicable to any kind of organization. Here our focus is on the articulation of further research needed for the IT-enabled business innovation, resilience and effectiveness. At a high level, see Figure 1, the related research topics are 1) ACE Co-engineering Theory which covers the development of context- based methods for the conceptualization, prioritization, and implementation of service-oriented solutions; 2) Knowledge Infrastructure for delivery of services, 3) Integrated Development Environment for service life-cycle management and continuous improvement of highly distributed complex systems, and 4) Transformation and Innovation Practice. While it is true that technology research in emerging trends like bio-info-nano integration will increase in importance, there is also a fundamental realization that the management of complexity will itself become a critical area of research. This is especially true since other related IT trends like virtualization, miniaturization, and distribution will also increase the complexity of deployed systems. Here we will explore the underlying challenges.