Serum Hepcidin Hormone Level and Its Genes Polymorphism

This chapter sheds light on hepcidin, historical view of hepcidin, and the time of its discovery in the first section. Then this chapter gives information about the genetic aspect and the importance of gene knowledge of hepcidin in explaining many disorders in human beings, supported by illustration figures. The regulation of iron in the human body as an essential function of hepcidin is discussed in this chapter. Examples of the genes of hepcidin (HAMP and HFE) are highlighted in detail as they are essential in regulating iron as well as discussing the genetic mutations that occur in these genes and their medical and clinical impacts for many diseases such as thalassemia. Finally, the inherited disorders related to hepcidin that lead to genetic diseases are discussed.

Exploring Plant Genetic Variations with Morphometric and Molecular Markers

For centuries, crop improvement has served as the basis of food security of ever increasing human population. Though vast germplasm collections are available; their exploitation for crop improvement still depends upon efficient assessment of genetic diversity. Genetic variability is the key element in adaptation of plants to varying climates. While crops with narrow genetic diversity are vulnerable to stresses. The estimation of extent and pattern of genetic variability is a prerequisite for generating superior varieties. Genetic diversity analysis generates key information to dissect genetic variations in crop germplasm with the help of morphometrical, biochemical and molecular tools. Among these, DNA markers provide a reliable and detailed insight into the similarities and differences among crops. In this chapter, we discuss the applications of phenotypic and molecular markers to probe genetic divergence in crops and present case studies that describe the significance of these tools to characterize sorghum germplasm. Furthermore, we spotlight sorghum biodiversity exploration efforts worldwide and propose future directions.

Genetic Variability through Induced Mutation

The success of plant breeding is based on the accessibility of genetic variation, information about desired traits with well-organized approach that make it likely to develop existing genetic resources. Food security demands to break the yield barrier through increasing new cultivars which can adapt to wide range of environment. It is especially important to observe the character association for yield along with its components before recognizing novel technique to break the yield barrier. There are numerous methods for improved exploiting of the inherent genetic makeup of crops with heritable variations. It is recommended that recognized parental resources can also be induced to mutate for unmasking novel alleles of genes that organize the traits suitable for the crop varieties of the 21st century world. Chemical mutagens have extensively been applied to make genetic changes in crop plants for breeding investigation as well as genetic studies. Ethyl methane sulphonate (EMS) is the most frequently applied as chemical agents in plants. EMS normally induces GC → AT transitions in the genome causing mutated protein that performed different functions rather than normal. It is exposed that the utilization of EMS is an efficient approach for developing novel gene pool.

Genetics in Osteoarthritis Knee

Osteoarthritis (OA) is a debilitating joint disorder with a complex pathogeny wherein diverse factors interact, causing a process of deterioration of the articular cartilage and the subchondral bone. It can be primary or secondary but has common clinical, radiological, and pathological manifestations. Unfortunately, there are no curative or preventive options available for this disease. The knee is the most common site to develop OA among all synovial joints. Both environmental and genetic factors play an essential role in the initiation of the disease. Identifying the genes underlying the genetic background could give new insights into the pathophysiology of knee osteoarthritis (KOA) and could potentially lead to new drug targets. Several genes involving developmental processes or maintenance of cartilage and bone are found to be associated with KOA susceptibility and progression. Understanding the gene functions has improved the knowledge towards the disease pathogenesis. So, it will be of interest to investigate the role of gene-gene interaction in the disease.