But how should a community manage its efforts? Locales seeking to promote innovation-based growth must think carefully not only about the needed actions, but also about the public agencies chosen to lead them. Strikingly, there has been almost no research on how to design and develop innovation agencies. Further, anyone who wants to model innovation agencies on the example of successful organizations could be forgiven for ending in utter confusion. Effective innovation agencies include large, powerful, central organizations as well as small, lightly funded ones. Some innovation agencies have clear technological objectives and manage much of the research themselves, whereas others have delegated these decisions to private sector actors. In short, there is considerable variation, with no clear lessons. The chapter cuts through this fog by demonstrating that the different designs of innovation agencies are similar to the different innovation models needed to excel in different stages of production, and each of which necessitates different set of capabilities. Effective institutional design thus depends on an agency’s mission or the specific type of innovation it seeks to pursue. The chapter distinguishes among four different types of innovation agencies, illustrated by multiple case studies: “directed upgraders,” “productivity facilitators,” “state-led disruptors,” and “transformation enablers.” These categories reflect different choices concerning (i) the level of public sector R&D involvement, (ii) the positioning of the agencies within the public sector, and (iii) the degree of embedding within private industry. Building on these case studies, the chapter discusses the implications for communities as they plan their innovation-based future.