Distressing side-effects of minocycline hydrochloride

Nasal involvement in lepromatous leprosy is universal and occurs early in the course of the disease. Nasal symptoms include obstruction, crusting, bleeding, and hyposmia. Traditional therapy with dapsone, rifampin, and clofazimine is limited by its cost and toxicity. Minocycline hydrochloride, a tetracycline antibiotic with limited side effects, is promising as a new treatment for leprosy. A case is presented that highlights the clinical presentation, diagnosis, and treatment of lepromatous leprosy.

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A Comparative Trial of Minocin (Minocycline Hydrochloride) and Ampicillin in the Treatment of Acute Exacerbations of Chronic Bronchitis

Journal of International Medical Research ◽

10.1177/030006057500300503 ◽

1975 ◽

Vol 3 (5) ◽

pp. 304-308 ◽

Cited By ~ 4

Author(s):

G R F Burrow ◽

A S Fox ◽

R J E Daniel

Keyword(s):

Clinical Trial ◽

Side Effects ◽

Chronic Bronchitis ◽

Therapeutic Efficacy ◽

Comparative Trial ◽

Double Blind ◽

Significant Difference ◽

Acute Exacerbations ◽

Minocycline Hydrochloride ◽

Long Acting

One hundred and fifteen patients suffering from acute exacerbations of chronic bronchitis took part in a double-blind, multicentre, clinical trial designed to compare the therapeutic efficacy and tolerability of ampicillin and minocycline hydrochloride, a new, long-acting, semi-synthetic tetracycline. Both antibiotics were equally successful in treatment, there being no statistically significant difference between the two in any of the parameters studied. Side-effects were few and far between. Only one patient out of the 57 who took minocycline, complained of dizziness.

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Distressing Side-Effects of Minocycline Hydrochloride

Archives of Internal Medicine ◽

10.1001/archinte.1976.03630070009005 ◽

1976 ◽

Vol 136 (7) ◽

pp. 761 ◽

Cited By ~ 13

Author(s):

W. Lee Fanning

Keyword(s):

Side Effects ◽

Minocycline Hydrochloride

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SIDE-EFFECTS OF MINOCYCLINE HYDROCHLORIDE

The Lancet ◽

10.1016/s0140-6736(74)90893-9 ◽

1974 ◽

Vol 304 (7889) ◽

pp. 1139 ◽

Cited By ~ 5

Author(s):

G. Masterton ◽

C.B.S. Schofield

Keyword(s):

Side Effects ◽

Minocycline Hydrochloride

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Topical Application of Minocycline Hydrochloride and Systemic Nicotinamide and Traditional Chinese Medicine for Benign Mucous Membrane Pemphigoid: A Case Report

10.22541/au.163406413.33046845/v1 ◽

2021 ◽

Author(s):

QianQian Wang ◽

Miao Li ◽

XiuYun Ren ◽

Fang Zhang ◽

Bin Zhao ◽

...

Keyword(s):

Case Report ◽

Chinese Medicine ◽

Side Effects ◽

Traditional Chinese Medicine ◽

Mucous Membrane ◽

Healing Process ◽

Mucous Membrane Pemphigoid ◽

Systemic Glucocorticoid ◽

History Of ◽

Minocycline Hydrochloride

A history of recurrent benign mucous membrane pemphigoid episodes had plagued patients. Major treatments include immunosuppressant or systemic glucocorticoid drugs, but all of them have side effects. Therefore, we tried to find a way to minimize side effects by using traditional Chinese medicine, and speeding up the healing process.

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Gastric Ulcers Produced by Cisplatin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099337 ◽

1981 ◽

Vol 39 ◽

pp. 582-583

Author(s):

S.K. Aggarwal ◽

J. San Antonio

Keyword(s):

Electron Microscopy ◽

Single Dose ◽

Side Effects ◽

Antitumor Agent ◽

Gastric Ulcers ◽

Enzyme Cytochemistry ◽

Intestinal Toxicity ◽

Ovarian Cancers ◽

Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

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Effects of cisplatin treatment on the rat neurohypophysis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100142256 ◽

1986 ◽

Vol 44 ◽

pp. 122-123

Author(s):

J.M. Fadool ◽

P.J. Boyer ◽

S.K. Aggarwal

Keyword(s):

Side Effects ◽

Urine Output ◽

Morphological Changes ◽

Limiting Factor ◽

Antineoplastic Drugs

Cisplatin (CDDP) is currently one of the most valuable antineoplastic drugs available. However, it has severe toxic side effects of which nephrotoxicity is the major dose limiting factor in its use. It induces morphological changes in the kidney with hampered urine output. The present study is an effort to determine the influence of the drug on the neurohypophysis for any antidiuretic effects on the kidney.

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Severe Drooling and Treatment With Botulinum Toxin

Perspectives on Swallowing and Swallowing Disorders (Dysphagia) ◽

10.1044/sasd21.1.15 ◽

2012 ◽

Vol 21 (1) ◽

pp. 15-21

Author(s):

Merete Bakke ◽

Allan Bardow ◽

Eigild Møller

Keyword(s):

Botulinum Toxin ◽

Side Effects ◽

Health Risk ◽

Flow Rate ◽

Clinical Evidence ◽

Acetylcholine Release ◽

Psychosocial Problems ◽

Rate Reduction ◽

Local Inhibition ◽

Surgical Treatments

Severe drooling is associated with discomfort and psychosocial problems and may constitute a health risk. A variety of different surgical and non-surgical treatments have been used to diminish drooling, some of them with little or uncertain effect and others more effective but irreversible or with side effects. Based on clinical evidence, injection with botulinum toxin (BTX) into the parotid and submandibular glands is a useful treatment option, because it is local, reversible, and with few side effects, although it has to be repeated. The mechanism of BTX is a local inhibition of acetylcholine release, which diminishes receptor-coupled secretion and results in a flow rate reduction of 25–50% for 2–7 months.

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