Treatment of Malignant Tumors of Minor Salivary Glands

Surgery was performed on 622 patients with tumors of the salivary glands from 1929 to 1972; the gland affected was the parotid in 527 cases, the submandibular glands in 50, and minor salivary glands of palate and other sites in 45. The analysis of distant results point out that both for benign and malignant tumors total sialoadenectomy must be the treatment of choice, as demonstrated by the high rate of recurrence after local excision or partial resection of the gland, even in cases of surely benign lesions such as mixed tumors. It is worthy of being quoted the high rate of recurrence from cylindromas, especially of the palate (48.5%), after surgical removal. As to malignancies of parotid and submandibular glands 5-years survival rates after radical surgery were of 52 % and 30 % respectively.

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Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature

Allergy & Rhinology ◽

10.1177/2152656719889030 ◽

2019 ◽

Vol 10 ◽

pp. 215265671988903 ◽

Cited By ~ 1

Author(s):

Madison J. Malfitano ◽

Meghan N. Norris ◽

Wesley H. Stepp ◽

Griffin D. Santarelli ◽

T. Danielle Samulski ◽

...

Keyword(s):

Case Report ◽

Salivary Glands ◽

Clear Cell ◽

Malignant Tumors ◽

Treatment Strategies ◽

Low Grade ◽

Minor Salivary Glands ◽

Presenting Symptoms ◽

Nasopharyngeal Mass ◽

The Right

Background Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx. Methods A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Results A 48-year-old man underwent biopsy of a 4.5 cm mass of the right nasopharynx with pathology suggesting an intermediate grade mucoepidermoid carcinoma. After discussing management with the patient, an endoscopic resection was performed. Final pathology revealed an HCCC which was confirmed after negative Mastermind-like 2 (MAML2) and positive Ewing sarcoma breakpoint region 1 (ESWR1) gene rearrangements on fluorescence in situ hybridization (FISH) studies. Literature review of other nasopharyngeal HCCC cases shows diverse presentation and overall excellent prognosis through surgical and radiation therapy. Conclusion HCCCs are rare, low-grade malignant tumors of the minor salivary glands and can present as a nasopharyngeal mass. Presenting symptoms are diverse but frequently involve otologic and sinonasal disturbances. HCCC is an indolent tumor with an excellent prognostic outcome when treated appropriately with surgical resection and adjuvant radiotherapy.

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Postoperative radiation therapy for malignant tumors of minor salivary glands. Outcome and patterns of failure

Cancer ◽

10.1002/1097-0142(19940515)73:10<2563::aid-cncr2820731018>3.0.co;2-x ◽

1994 ◽

Vol 73 (10) ◽

pp. 2563-2569 ◽

Cited By ~ 128

Author(s):

Adam S. Garden ◽

Randal S. Weber ◽

K. Kian Ang ◽

William H. Morrison ◽

Jan Matre ◽

...

Keyword(s):

Radiation Therapy ◽

Salivary Glands ◽

Malignant Tumors ◽

Minor Salivary Glands ◽

Postoperative Radiation ◽

Patterns Of Failure ◽

Postoperative Radiation Therapy

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Surgery for Malignant Tumors of the Minor Salivary Glands

Salivary Gland Cancer ◽

10.1007/978-3-030-02958-6_7 ◽

2019 ◽

pp. 97-122

Author(s):

Davide Lombardi ◽

Remo Accorona ◽

Davide Lancini ◽

Vittorio Rampinelli ◽

Anna Bozzola ◽

...

Keyword(s):

Salivary Glands ◽

Malignant Tumors ◽

Minor Salivary Glands

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Minor intraoral salivary gland tumors: a clinical-pathological study

Einstein (São Paulo) ◽

10.1590/s1679-45082016ao3749 ◽

2016 ◽

Vol 14 (4) ◽

pp. 508-512 ◽

Cited By ~ 3

Author(s):

Dmitry José de Santana Sarmento ◽

◽

Maria de Lourdes Silva de Arruda Morais ◽

Antonio de Lisboa Lopes Costa ◽

Éricka Janine Dantas da Silveira ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Mucoepidermoid Carcinoma ◽

Malignant Tumors ◽

Minor Salivary Gland ◽

Malignant Neoplasms ◽

Minor Salivary Glands ◽

Pathological Study ◽

Hematoxylin And Eosin ◽

Retromolar Region

ABSTRACT Objective To evaluate the clinical-pathological profile of patients with minor salivary gland neoplasms. Methods A retrospective study of specific cases diagnosed as benign and malignant tumors of the minor salivary glands was performed. The data were collected from medical records of patients seen at a hospital over a period of 15 years. The sample was made up of 37 cases. For the pathological study, slides containing 5μm thick sections stained with hematoxylin and eosin were used. The data were tabulated using descriptive statistics. Results Malignant neoplasms represented 70.3% of cases. The mucoepidermoid carcinoma was the most common neoplasm (45.9%), followed by pleomorphic adenoma (24.4%). Most patients were female (70.3%), aged between 71 and 80 years. The palate (67.6%) and the retromolar region (10.8%) were the most affected sites. Conclusion Mucoepidermoid carcinoma was the most common tumor in minor salivary glands. These tumors are more common in females aged over 40 years. The palate was the most common affected site.

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A Demographic Study on Oral Non Squamous Cell Malignant Tumors

Update Dental College Journal ◽

10.3329/updcj.v3i2.17997 ◽

2014 ◽

Vol 3 (2) ◽

pp. 34-38

Author(s):

Md Amirul Islam ◽

Md Shahjahan Ali ◽

Md Mahfuz Hossain ◽

Md Nazmul Hasan ◽

Tazdik G Chowdhury

Keyword(s):

Malignant Melanoma ◽

Salivary Glands ◽

Squamous Cell ◽

Clinical Presentation ◽

Malignant Tumors ◽

Maxillofacial Surgery ◽

Malignant Neoplasm ◽

Minor Salivary Glands ◽

Female Ratio ◽

Oral Malignancies

Background: Nonsquamous cell malignant tumors of jaw and oral soft tissue are rare constituting between 6%-10% of all malignancies in the region. A few case reports of individual tumors are available while reviews of significant series is lacking. This report presents 22 cases of Nonsquamous cell malignant tumors collected over 8 months at a tertiary oral care centre in Dhaka, Bangladesh. Objective: To find out the distribution & pattern of oral nonsquamous cell malignant tumors among all oral malignancy and to find out the age, sex, site, clinical presentation, the histological types of these tumors. Method: This descriptive cross sectional study was done in Oral and Maxillofacial Surgery Department, Dhaka Dental College and Hospital.The entire patient histopathologically diagnosed as any type of Nonsquamous cell tumor were selected. Data were collected in a summarized data sheet. Then histopathological types of them were analyzed to indicate the distribution according to age, gender, site and clinical presentation. Result: There were 107 Oral malignancies of which 22(20.56%) were Nonsquamous cell malignant tumors which is significant in comparison to Squamous cell carcinoma in Bangladesh. Among the respondents, 9(40.91%) were diagnosed as minor salivary glands malignant tumors, 7(31.2%) were diagnosed as sarcomas, Malignant melanoma were 4(18.18%) and Non- Hodgkins lymphoma were 2(9.09%). The male to female ratio was 1:1.2 with ages were between 9 years to 70 years old (mean age 35.45 ± 21.76 years) with most patients (36.36%) in 16 to 30 years of life. Cases presented with symptoms such as swelling (100%), pain, paresthesia, loose tooth and tissue ulceration. Conclusion: In Dhaka Dental College Hospital, nonsquamous cell malignant tumors account for 20.56% of all oral malignancies among them minor salivary glands malignant neoplasm and malignant melanoma were the predominant type. Most affected were people in the 2nd and 3rd decades of life with no sex predilection. Most common site of involvement was maxilla. The need for improved medical awareness, diagnostic facilities and upgrading of infrastructure was stressed. DOI: http://dx.doi.org/10.3329/updcj.v3i2.17997 Update Dent. Coll. j: 2013; 3 (2): 34-38

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Laryngeal adenoid cystic carcinoma: case report

Sao Paulo Medical Journal ◽

10.1590/s1516-31802007000500010 ◽

2007 ◽

Vol 125 (5) ◽

pp. 295-296 ◽

Cited By ~ 14

Author(s):

André Del Negro ◽

Edson Ichihara ◽

Alfio José Tincani ◽

Albina Altemani ◽

Antônio Santos Martins

Keyword(s):

Case Report ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Clinical Characteristics ◽

Clinical Course ◽

Malignant Tumors ◽

Definitive Treatment ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Therapeutic Evaluation

CONTEXT: Adenoid cystic carcinomas are malignant tumors that occur in both the major and the minor salivary glands. A laryngeal location is rare because of the paucity of accessory salivary glands in this area. Adenoid cystic carcinomas account for less than 1% of all malignant tumors in the larynx, and only about 120 cases have been reported in the literature. These tumors have a slight female predisposition, and their peak incidence is in the fifth and sixth decades of life. In this article, we describe a case of laryngeal adenoid cystic carcinoma and discuss its clinical characteristics and treatment. CASE REPORT: We report on a case of laryngeal adenoid cystic carcinoma in a 55 year-old female patient who presented with dyspnea and hoarseness. Features of the diagnostic and therapeutic evaluation are described and the clinical management of such cases is outlined. The clinical course, definitive treatment strategy and surgical procedure, and also adjuvant treatment with irradiation are discussed. Although the tumor is radiosensitive, it is not radiocurable.

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