Long-term Cognition, Achievement, Socioemotional, and Behavioral Development of Healthy Late-Preterm Infants

In order to explore the prediction effect of amplitude-integrated EEG on the brain damage and long-term nervous system development of late preterm infants, this paper uses the hospital’s late preterm infants as the research object and analyzes the prediction effect of amplitude-integrated EEG on the brain damage and long-term nervous system development of late preterm infants through controlled trials. Among them, the test group used amplitude-integrated EEG for prediction analysis, and the control group used traditional clinical prediction methods. Furthermore, the real-time monitoring and short-term prediction effects of amplitude-integrated EEG on brain damage in late preterm babies and the prediction impact on long-term nervous system development are evaluated in this study. It incorporates statistical techniques to evaluate the findings statistically. In addition, a nonparametric rank-sum test is used in this work, and a chi-square test is used to compare enumeration data across groups. Through experimental research, it can be seen that the amplitude-integrated EEG has a pronounced prediction effect on the brain damage and long-term nervous system development of late preterm infants, and the effect is higher than that of the traditional clinical prediction methods.

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Late prematuriteit: een risicopopulatie?

Tijdschrift voor Geneeskunde ◽

10.47671/tvg.77.21.075 ◽

2021 ◽

Author(s):

B. DEVOCHT ◽

K. SMETS ◽

L. GARABEDIAN

Keyword(s):

Preterm Infants ◽

Relative Size ◽

Late Preterm ◽

Late Preterm Infant ◽

Term Infants ◽

Feeding Difficulties ◽

Developmental Problems ◽

Late Preterm Infants ◽

Near Term

Late preterm infant: a population at risk? Late preterm infants, infants born between 34 0/7 and 36 6/7 weeks of gestation, were called near term before 2005, which may lead to the assumption that they are mature and an underestimation of their risks. Late preterm infants are physiologically and metabolically immature. Compared to term infants they have increased morbidity rates, including problems such as hypothermia, hypoglycemia, hyperbilirubinemia, feeding difficulties and respiratory and immunological issues. In late preterm infants there are increased mortality rates, prolonged hospitalizations at birth, more readmissions and higher healthcare costs. The infants also have a higher risk of neurological and developmental problems and long-term respiratory, cardiovascular and metabolic difficulties. Despite their relative size and apparently mature appearance, late preterm infants should not be treated like term infants. They require careful monitoring immediately after birth, as well as during childhood and even adolescence. Child-birth should not be scheduled during the late preterm period without medical indication. The risk of continuing the pregnancy must be weighed against the risk of premature birth. The prevention and a better monitoring of late preterm infants can lead to healthcare savings.

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Early amplitude-integrated EEG monitoring 6 h after birth predicts long-term neurodevelopment of asphyxiated late preterm infants

European Journal of Pediatrics ◽

10.1007/s00431-015-2490-z ◽

2015 ◽

Vol 174 (8) ◽

pp. 1043-1052 ◽

Cited By ~ 11

Author(s):

Chun-Ming Jiang ◽

Yi-Hua Yang ◽

Li-Qiong Chen ◽

Xiang-Hua Shuai ◽

Hui Lu ◽

...

Keyword(s):

Preterm Infants ◽

Late Preterm ◽

Eeg Monitoring ◽

Late Preterm Infants

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Neurological development and iron supplementation in healthy late-preterm neonates: a randomized double-blind controlled trial

European Journal of Pediatrics ◽

10.1007/s00431-021-04181-1 ◽

2021 ◽

Author(s):

R. Luciano ◽

D. M. Romeo ◽

G. Mancini ◽

S. Sivo ◽

C. Dolci ◽

...

Keyword(s):

Iron Deficiency ◽

Preterm Infants ◽

Iron Supplementation ◽

Late Preterm ◽

Double Blind ◽

Late Preterm Infants ◽

Neurological Outcomes ◽

Increased Risk ◽

The Mean

AbstractLate-preterm infants (LPT) are at increased risk for long-term neurodevelopmental sequelae and iron deficiency. The aim of the study is to assess the positive effect of iron supplementation on psychomotor development in healthy LPT. We designed a randomized placebo-controlled double-blind trial dividing the newborns into two groups. Every patient was assessed using the Griffiths Mental Development Scales (GMDS)-II edition at 12-month post-conceptional age. The study was performed at the Neonatology Unit of our Hospital, in Italy. Sixty-six healthy LPT infants born between 340⁄7 and 366⁄7 weeks of gestational age were enrolled in the study. One group received martial prophylaxis from the third week of life to 6 months of post-conceptional age (2 mg/kg/day of iron pidolate), the other received placebo. Fifty-two of the enrolled infants were assessed using the GMDS at 12-month of post-conceptional age. Statistical analysis of the mean scores of the Griffiths subscales was performed. There was a difference in the mean developmental quotient (DQ) (p < 0.01) between the two groups: iron group mean DQ 121.45 ± 10.53 vs placebo group mean DQ 113.25 ± 9.70. Moreover, mean scores of the Griffiths subscales A, B, and D showed significant differences between the two groups (scale A p < 0.05, scale B p < 0.02, scale D p < 0.01, respectively).Conclusions: We recommend that all LPT neonates receive iron supplementation during the first 6 months of life in order to improve their 1-year neurodevelopmental quotient. What is Known:• Late-preterm infants (LPT) are at increased risk for long-term neurodevelopmental sequelae and also for iron deficiency.• Iron deficiency is an independent risk factor for adverse neurological outcomes. What is New:• Healthy late-preterm who received iron supplementation during the first 6 months of life achieved better neurological outcomes at 12-month post-conceptional age than LPT who received placebo.• Our study strongly supports the need for the implementation of martial prophylaxis in LPT neonates.

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