scholarly journals Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function

JAMA ◽  
2015 ◽  
Vol 314 (8) ◽  
pp. 791 ◽  
Author(s):  
Emily Y. Chew ◽  
Traci E. Clemons ◽  
Elvira Agrón ◽  
Lenore J. Launer ◽  
Francine Grodstein ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Function ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Nutrient Supplementation

scholarly journals Omega-3 Fatty Acids and Fecundation, Pregnancy and Breastfeeding

2020 ◽  
Vol 42 (03) ◽  
pp. 160-164
Author(s):  
Carlos Alberto Politano ◽  
Jorge López-Berroa
Keyword(s):  
Fatty Acids ◽  
Cognitive Function ◽  
Oocyte Maturation ◽  
Neurodevelopmental Disorders ◽  
Fetal Development ◽  
Premature Delivery ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Docosahexaenoic Acids ◽  
Long Chain

AbstractLong-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as the eicosapentaenoic and docosahexaenoic acids, have been linked to human health in all stages of life, from fetal development to aging. These PUFAs act as precursors for various metabolites involved in the prevention of certain diseases. The recognizable effects of these supplements prior to pregnancy (oocyte maturation), during pregnancy (improvement in the risk of premature delivery, among others) and in the offspring (in terms of cognitive function and the approach to neurodevelopmental disorders) are described in the present narrative review. We concluded that the diffusion of these supplements may improve the prognosis of these patients in a simple, effective way, and with high safety rates.

scholarly journals Cognitive function after supplementation with B vitamins and long-chain omega-3 fatty acids: ancillary findings from the SU.FOL.OM3 randomized trial

2011 ◽  
Vol 94 (1) ◽  
pp. 278-286 ◽  
Author(s):  
Valentina A Andreeva ◽  
Emmanuelle Kesse-Guyot ◽  
Pascale Barberger-Gateau ◽  
Léopold Fezeu ◽  
Serge Hercberg ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Function ◽  
Randomized Trial ◽  
B Vitamins ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Long Chain

scholarly journals Omega-3 Fatty Acids and Cognitive Function in Women

2010 ◽  
Vol 6 (1) ◽  
pp. 119-134 ◽  
Author(s):  
Jennifer G Robinson ◽  
Nkechinyere Ijioma ◽  
William Harris
Keyword(s):  
Fatty Acids ◽  
Cognitive Function ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Regional Brain Volumes As Mediators of the Association Between Circulating Omega-3 Fatty Acids and Cognitive Function: The Boston Puerto Rican Health Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1014-1014
Author(s):  
Sherman Bigornia ◽  
Guan Yi ◽  
Bang-Bon Kim ◽  
Xiyuan Zhang ◽  
Tammy Scott ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cognitive Function ◽  
Puerto Rican ◽  
Acid Concentration ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Global Cognitive Function ◽  
Regional Brain

Abstract Objectives To assess the mediating role of regional brain volume in the relationship between circulating very-long-chain omega-3 fatty acids and global cognitive function. Methods Data are from individuals of the Boston Puerto Rican Health Study with a T1-weighted MRI brain scan available approximately 8 y from the baseline visit (n = 200, mean age at baseline = 54.7 y, 77.5% female). Red blood cell fatty acid composition was measured at baseline and very-long-chain omega-3 fatty acid was defined as the sum of EPA and DHA. A battery of 7 cognitive tests was administered at baseline and 8-y follow-up in the language of preference. Global cognitive function was the average z-score of the cognitive tests. Whole MRI brain volumetric measures (of cortical and subcortical grey matter) were quantified using the FreeSurfer processing pipeline. Structural equation modeling was conducted to examine the mediating effect of regional brain volumetric measures on the association between omega-3 fatty acid concentration and global cognitive function. Bivariate associations were assessed by age- and sex-adjusted partial Spearman's rho correlation coefficient with FDR correction. Results The association between baseline omega-3 fatty acid concentration and 8-y global cognitive function was mediated by several cortical regions including the left caudal middle frontal gyrus, right inferior parietal lobes, and right isthmus of cingulate gyrus. Significant mediators in the subcortex included the putamen, amygdala, left ventral dorsal tract, and right thalamus. Omega-3 fatty acid concentration was positively correlated with global cognitive function (rs = 0.17, P < 0.05) and with brain regions identified as significant mediators (rs = 0.17 to 0.21, P < 0.05 for all). Greater volume of the brain region mediators was associated with higher global cognitive function score (rs = 0.17 to 0.24, P < 0.05 for all). Conclusions These results suggest that, among older Puerto Rican adults, greater circulating omega-3 fatty acids may be related to better cognitive function and that this relationship may be explained by maintenance of specific cortical and subcortical brain regions. Funding Sources NIA R01AG055948.

scholarly journals Omega-3 fatty acids moderate effects of physical activity on cognitive function

2014 ◽  
Vol 59 ◽  
pp. 103-111 ◽  
Author(s):  
Regina L. Leckie ◽  
Stephen B. Manuck ◽  
Neha Bhattacharjee ◽  
Matthew F. Muldoon ◽  
Janine M. Flory ◽  
...  
Keyword(s):  
Physical Activity ◽  
Fatty Acids ◽  
Cognitive Function ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Dietary and supplemental long-chain omega-3 fatty acids as moderators of cognitive impairment and Alzheimer’s disease

2021 ◽  
Author(s):  
Amy H. R. Wood ◽  
Helen F. Chappell ◽  
Michael A. Zulyniak
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Observational Studies ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Long Chain

Abstract Purpose There is an ever-growing body of literature examining the relationship between dietary omega-3 polyunsaturated fatty acids (ω3 PUFAs) and cerebral structure and function throughout life. In light of this, the use of ω3 PUFAs, namely, long-chain (LC) ω3 PUFAs (i.e., eicosapentaenoic acid and docosahexaenoic acid), as a therapeutic strategy to mitigate cognitive impairment, and progression to Alzheimer’s disease is an attractive prospect. This review aims to summarise evidence reported by observational studies and clinical trials that investigated the role of LC ω3 PUFAs against cognition impairment and future risk of Alzheimer’s disease. Methods Studies were identified in PubMed and Scopus using the search terms “omega-3 fatty acids”, “Alzheimer’s disease” and “cognition”, along with common variants. Inclusion criteria included observational or randomised controlled trials (RCTs) with all participants aged ≥ 50 years that reported on the association between LC ω3 PUFAs and cognitive function or biological markers indicative of cognitive function linked to Alzheimer’s disease. Results Evidence from 33 studies suggests that dietary and supplemental LC ω3 PUFAs have a protective effect against cognitive impairment. Synaptic plasticity, neuronal membrane fluidity, neuroinflammation, and changes in expression of genes linked to cognitive decline have been identified as potential targets of LC ω3 PUFAs. The protective effects LC ω3 PUFAs on cognitive function and reduced risk of Alzheimer’s disease were supported by both observational studies and RCTs, with RCTs suggesting a more pronounced effect in individuals with early and mild cognitive impairment. Conclusion The findings of this review suggest that individuals consuming higher amounts of LC ω3 PUFAs are less likely to develop cognitive impairment and that, as a preventative strategy against Alzheimer’s disease, it is most effective when dietary LC ω3 PUFAs are consumed prior to or in the early stages of cognitive decline.

scholarly journals The Efficacy of Omega–3 Fatty Acids on Cognitive Function in Aging and Dementia: A Systematic Review

2006 ◽  
Vol 21 (2) ◽  
pp. 88-96 ◽  
Author(s):  
Amalia M. Issa ◽  
Walter A. Mojica ◽  
Sally C. Morton ◽  
Shana Traina ◽  
Sydne J. Newberry ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
Cognitive Function ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

2019 ◽  
pp. 1-7
Author(s):  
Hadeer Zakaria ◽  
Tarek M. Mostafa ◽  
Gamal A. El-Azab ◽  
Nagy AH Sayed-Ahmed
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Fish Oil ◽  
Wheat Germ ◽  
Hemodialysis Patients ◽  
Nutritional Indices ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wheat Germ Oil ◽  
Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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