Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders

Background: Obesity is becoming an important issue for health promotion. The World Health Organization estimated that around 1.5 billion adults were overweight (body mass index (BMI) 25 kg/m2) and about 500 million people were obese (BMI 30 kg/m2) in 2008. The relationship between obesity and mental health is also considered important. In a community-based study, obesity was positively associated with several mental disorders, especially mood disorders and anxiety disorders. The aim of the study is the assessment of current and lifetime psychiatric disorders among morbidly obese patients. Methods: This case control study was conducted on 60 participants from outpatient clinic of GIT surgery unit and community. All participants were subjected to: Body weight and body mass index, Psychiatric interview for diagnosis of psychiatric disorders by Arabic version of MINI, Scale for diagnosis of Bulimia nervosa by Shokeer, Scale for diagnosis of Anorexia Nervosa by Shokeer, Binge Eating Disorder Screener-7, Eating attitude test, Hamilton Depressions Rating Scale and Hamilton anxiety scale. Results: There was a significant increase in anxiety in patients with morbid obesity compared to control group. There was a significant difference between both groups showing the high prevalence of depression in patients with morbid obesity. Based on EAT test, there was a significant prevalence of abnormal eating behaviors in patients group compared to none of control group. A screening test for the presence of Binge eating symptoms revealed significant increase of symptoms in patients’ group. Conclusions: Psychiatric disorders are prevalent in morbidly obese patients and are associated with significantly worse quality of life. In addition, morbidly obese patients had significantly worse physical and mental health relative to control group from general population. High rates of psychiatric disorders among morbidly obese patients seem to be the rule rather than an exception.

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Shared genetic influences on adolescent body mass index and brain structure: A voxel-based morphometry study in twins

NeuroImage ◽

10.1016/j.neuroimage.2019.05.053 ◽

2019 ◽

Vol 199 ◽

pp. 261-272 ◽

Cited By ~ 1

Author(s):

James T. Kennedy ◽

Serguei V. Astafiev ◽

Semyon Golosheykin ◽

Ozlem Korucuoglu ◽

Andrey P. Anokhin

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Brain Structure ◽

Genetic Influences ◽

Voxel Based Morphometry ◽

Shared Genetic

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Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Molecular Psychiatry ◽

10.1038/mp.2016.71 ◽

2016 ◽

Vol 22 (2) ◽

pp. 192-201 ◽

Cited By ~ 26

Author(s):

A Hinney ◽

◽

M Kesselmeier ◽

S Jall ◽

A-L Volckmar ◽

...

Keyword(s):

Body Mass Index ◽

Anorexia Nervosa ◽

Body Mass ◽

Genetic Loci

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Body Mass Index Status across Different Psychiatric Disorders in a National Survey amongst Children and Adolescents: To Identify the Role of Gender

Iranian Journal of Psychiatry ◽

10.18502/ijps.v14i4.1975 ◽

2019 ◽

Cited By ~ 1

Author(s):

Mohammad Reza Mohammadi ◽

Seyed-Ali Mostafavi ◽

Zahra Hooshyari ◽

Ali Khaleghi ◽

Nastaran Ahmadi

Keyword(s):

Body Mass Index ◽

Children And Adolescents ◽

Psychiatric Disorders ◽

Body Mass ◽

National Survey ◽

Separation Anxiety ◽

Separation Anxiety Disorder ◽

Oppositional Defiant ◽

The Status

Objective: Body mass index undergoes a substantial change in some psychiatric disorders. This study aimed to explore the status of body mass index (BMI) in different psychiatric disorders in a national survey among children and adolescents and to identify the role of gender in this regard. Method: A total of 30 532 children and adolescents were randomly selected using cluster sampling method with equal blocks of three age groups and two genders. Psychiatric disorders were assessed using a standardized face-to-face diagnostic interview of Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (KSADS-PL), and Body Mass Index (BMI) was measured for each participant. Results: In this study, 22 730 children and adolescents (109 46 boys and 11784 girls), with valid data of BMI, completed the KSADS-PL interview. The prevalence of psychiatric disorders was 21.2% among underweight participants, 22.8% among overweight participants, and 22.2% among obese participants, which was significantly higher than normal weight participants with 19.6% (X2 = 17.55; p = 0.001). In boys’ subgroup, depression and separation anxiety were mostly seen among the underweight category, while tic disorder was mostly seen in the obese category. In girls’ subgroup, on the other hand, generalized anxiety was mostly observed in the underweight category, while oppositional defiant disorder (ODD), depression, and mental retardation were mostly observed in the obese category. In total, the highest mean BMI rates were among the children and adolescents with alcohol abuse disorder, mania, and panic disorder. However, the lowest BMI rates were among those with attention deficit hyperactivity disorder (ADHD), separation anxiety disorder (SAD), and enuresis. Conclusion: This study gives an overall picture of BMI status in different psychiatric disorders according to gender. Furthermore, in a multidisciplinary approach, the results of this study drew the attention of child psychiatrists to the status of BMI in their clients.

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