The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control

Author(s):  
Luis Varela ◽  
Tamas L. Horvath
Author(s):  
Randy J. Seeley ◽  
Deborah J. Clegg ◽  
Michael W. Schwartz ◽  
Stephen C. Woods

1977 ◽  
Vol 36 ◽  
pp. 143-180 ◽  
Author(s):  
J.O. Stenflo

It is well-known that solar activity is basically caused by the Interaction of magnetic fields with convection and solar rotation, resulting in a great variety of dynamic phenomena, like flares, surges, sunspots, prominences, etc. Many conferences have been devoted to solar activity, including the role of magnetic fields. Similar attention has not been paid to the role of magnetic fields for the overall dynamics and energy balance of the solar atmosphere, related to the general problem of chromospheric and coronal heating. To penetrate this problem we have to focus our attention more on the physical conditions in the ‘quiet’ regions than on the conspicuous phenomena in active regions.


Author(s):  
Gandhi M. ◽  
Swaminathan S.

Ghrelin as human natural hormones is involved in fundamental regulatory process of eating and energy balance. It is a stomach derived hormone that acts as at the ghrelin receptor in multiple tissues throughout to the body. Its properties includes increasing appetite, decreasing systemic inflammation, decreasing vascular resistance ,increasing cardiac output, increasing glucose and IGF-1 levels, Hence it may play a significant role in Diabetes mellitus. Many studies have linked ghrelin to obesity and this paper is an attempt to bring out recent findings on the role of ghrelin in Diabetes Mellitus, particularly type2 Diabetes mellitus.


2020 ◽  
Vol 33 (1) ◽  
pp. 30-38
Author(s):  
Naglaa Y. Nafeh ◽  
Mona A. Said

Pharmacology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Vanessa Gonzalez-Covarrubias ◽  
Héctor Sánchez-Ibarra ◽  
Karla Lozano-Gonzalez ◽  
Sergio Villicaña ◽  
Tomas Texis ◽  
...  

<b><i>Introduction:</i></b> Genetic variants could aid in predicting antidiabetic drug response by associating them with markers of glucose control, such as glycated hemoglobin (HbA1c). However, pharmacogenetic implementation for antidiabetics is still under development, as the list of actionable markers is being populated and validated. This study explores potential associations between genetic variants and plasma levels of HbA1c in 100 patients under treatment with metformin. <b><i>Methods:</i></b> HbA1c was measured in a clinical chemistry analyzer (Roche), genotyping was performed in an Illumina-GSA array and data were analyzed using PLINK. Association and prediction models were developed using R and a 10-fold cross-validation approach. <b><i>Results:</i></b> We identified genetic variants on <i>SLC47A1, SLC28A1, ABCG2, TBC1D4,</i> and <i>ARID5B</i> that can explain up to 55% of the interindividual variability of HbA1c plasma levels in diabetic patients under treatment. Variants on <i>SLC47A1</i>, <i>SLC28A1</i>, and <i>ABCG2</i> likely impact the pharmacokinetics (PK) of metformin, while the role of the two latter can be related to insulin resistance and regulation of adipogenesis. <b><i>Conclusions:</i></b> Our results confirm previous genetic associations and point to previously unassociated gene variants for metformin PK and glucose control.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S406-S406
Author(s):  
Miyong T Kim

Abstract The purpose of this study was to explicate the underlying mechanisms of the role of health literacy (HL) in diabetes management process involving a group of Korean Americans with type 2 diabetes mellitus (DM). We used data from a randomized clinical trial of an HL-focused diabetes self-management intervention (n = 250). A series of path analyses identified the level of self-efficacy and self-care skills as a significant mediator between HL and glucose control (HbA1C) and quality of life for the target population. In addition, education and acculturation were revealed as the most significant correlates of HL for this new immigrant group. Despite inconsistent empirical findings regarding the statistically significant effect of HL on glucose control, this study confirmed the apriority hypothesis that HL indirectly influences health outcome through mediators such self-care skills as self-efficacy. This study highlighted the importance of HL in chronic disease management for people with limited HL.


Diabetes ◽  
2021 ◽  
pp. db201045
Author(s):  
Mattia Albiero ◽  
Serena Tedesco ◽  
Francesco Ivan Amendolagine ◽  
Marianna D'Anna ◽  
Ludovica Migliozzi ◽  
...  

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