Design, Simulation, and Dynamic Control of Large-Scale Manufacturing Process with Different forms of Uncertainties

Author(s):  
Hyunsoo Lee ◽  
Amarnath Banerjee
2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Peiran Zhang ◽  
Joseph Rufo ◽  
Chuyi Chen ◽  
Jianping Xia ◽  
Zhenhua Tian ◽  
...  

AbstractThe ability to precisely manipulate nano-objects on a large scale can enable the fabrication of materials and devices with tunable optical, electromagnetic, and mechanical properties. However, the dynamic, parallel manipulation of nanoscale colloids and materials remains a significant challenge. Here, we demonstrate acoustoelectronic nanotweezers, which combine the precision and robustness afforded by electronic tweezers with versatility and large-field dynamic control granted by acoustic tweezing techniques, to enable the massively parallel manipulation of sub-100 nm objects with excellent versatility and controllability. Using this approach, we demonstrated the complex patterning of various nanoparticles (e.g., DNAs, exosomes, ~3 nm graphene flakes, ~6 nm quantum dots, ~3.5 nm proteins, and ~1.4 nm dextran), fabricated macroscopic materials with nano-textures, and performed high-resolution, single nanoparticle manipulation. Various nanomanipulation functions, including transportation, concentration, orientation, pattern-overlaying, and sorting, have also been achieved using a simple device configuration. Altogether, acoustoelectronic nanotweezers overcome existing limitations in nano-manipulation and hold great potential for a variety of applications in the fields of electronics, optics, condensed matter physics, metamaterials, and biomedicine.


Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4362-4362
Author(s):  
Jürgen Siekmann ◽  
Purtscher Martin ◽  
Oliver Zöchling ◽  
Robert Kellerer ◽  
Hanspeter Rottensteiner ◽  
...  

Abstract Abstract 4362 Baxter and Nektar have developed BAX 855, a PEGylated form of Baxter’s recombinant FVIII (rFVIII) product based on the ADVATE™ manufacturing process. The conjugation process for preparing BAX 855 uses proprietary stable PEGylation from Nektar Therapeutics. Similar Nektar technology has been successfully employed for marked and licensed PEGylated drug products and drugs in clinical use. The manufacturing process for BAX 855 comprises several steps, including chromatographic purification on a MacroCap SP resin, a strong cation exchanger, which allows the fractionation of species with different PEGylation degrees and concentration of the conjugate collected by an ultra- / diafiltration step leading to the pre-formulated bulk drug substance (BDS). Final formulation of the BDS includes a filling and lyophilization step to obtain the final drug product. The process described is suited to manufacture BAX 855 in gram scale and showed a good batch to batch consistency, ensuring an equivalent product quality for each batch. BAX 855 manufactured by this process has a specific activity similar to that of rFVIII in ADVATE™ and PEGylation degrees in the narrow range of 2 to 3 mols PEG / mol rFVIII. SDS-PAGE and Western blot analysis of BAX 855 confirm the stable PEGylation and demonstrate an increase in the molecular weight of the various FVIII domains. PK studies in different species display longer survival of BAX 855 compared to ADVATE™. Disclosures: Siekmann: Baxter Innovations GmbH: Employment. Martin:Baxter Innovations GmbH: Employment. Zöchling:Baxter Innovations GmbH: Employment. Kellerer:Baxter Innovations GmbH: Employment. Rottensteiner:Baxter Innovations GmbH: Employment. Mitterer:Baxter Innovations GmbH: Employment. Bossard:Nektar Therapeutics: Employment. Phillips:Nektar Therapeutics: Employment. Ehrlich:Baxter Innovations GmbH: Employment. Scheiflinger:Baxter Innovations GmbH: Employment. Turecek:Baxter Innovations GmbH: Employment.


2002 ◽  
Vol 17 (10) ◽  
pp. 2484-2488 ◽  
Author(s):  
Travis L. Brown ◽  
Srinivasan Swaminathan ◽  
Srinivasan Chandrasekar ◽  
W. Dale Compton ◽  
Alexander H. King ◽  
...  

In spite of their interesting properties, nanostructured materials have found limited uses because of the cost of preparation and the limited range of materials that can be synthesized. It has been shown that most of these limitations can be overcome by subjecting a material to large-scale deformation, as occurs during common machining operations. The chips produced during lathe machining of a variety of pure metals, steels, and other alloys are shown to be nanostructured with grain (crystal) sizes between 100 and 800 nm. The hardness of the chips is found to be significantly greater than that of the bulk material.


Author(s):  
ALISTAIR D. C. HOLDEN ◽  
STEVEN C. SUDDARTH

The control of small-scale systems using either knowledge-based or neural net methods is quite feasible. Large scale systems, however, introduce complexities in modeling and excessive computation time. This paper attacks these difficulties by breaking down the problem into a hierarchy of control contexts. The lowest level of this hierarchy is implemented as rule sets and/or neural networks. A method using "hints" is shown to greatly reduce training time in back-propagation neural nets.


2014 ◽  
Vol 615 ◽  
pp. 88-92
Author(s):  
Tian Shu Bi ◽  
Jin Meng Chen

It has significant impact on the safe operation of the power grid for large scale power transformer. The technique is complex, and the manufacture process is long. The users always take the manufacturing supervision on spot as the quality control method. The quality is determined during the manufacturing process. The quality defects may cause serious safe problems. It has important significance to strengthen the risk assessment and prevention. The quality defects of power transformer are classified based on the fault tree analysis theory. The quality defects of power transformer from the manufacturing supervision of State Grid Corporation of China (SGCC) in 2012 are analyzed as examples. The manufacturing process has multiple layers and factors. The index system for comprehensive evaluation of transformer is put forward. A risk assessment model for power transformer based on fuzzy synthetic evaluation is built. The example shows that the method can estimate the risk effectively. It can provide feasible decision basis for the risk management and maintenance.


ChemInform ◽  
2010 ◽  
Vol 29 (26) ◽  
pp. no-no
Author(s):  
J. D. HAYLER ◽  
S. L. B. HOWIE ◽  
R. G. GILES ◽  
A. NEGUS ◽  
P. W. OXLEY ◽  
...  

2014 ◽  
Vol 933 ◽  
pp. 482-486
Author(s):  
Masaya Yoshikawa ◽  
Yusuke Mori ◽  
Takeshi Kumaki

Recently, the threat of hardware Trojans has garnered attention. Hardware Trojans are malicious circuits that are incorporated into large-scale integrations (LSIs) during the manufacturing process. When predetermined conditions specified by an attacker are satisfied, the hardware Trojan is triggered and performs subversive activities without the LSI users even being aware of these activities. In previous studies, a hardware Trojan was incorporated into a cryptographic circuit to estimate confidential information. However, Trojan triggers have seldom been studied. The present study develops several new Trojan triggers and each of them is embedded in a field-programmable gate array (FPGA). Subsequently, the ease of detection of each trigger is verified from the standpoint of area.


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