Transcription Factors: Deciphering the Transcription Factor Network of Dendritic Cell Development

2008 ◽  
pp. 53-71
Author(s):  
Thomas Hieronymus ◽  
Martin Zenke
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Dendritic Cell ◽  
Cell Development ◽  
Transcription Factor Network

scholarly journals A RETINOBLASTOMA-RELATED transcription factor network governs egg cell differentiation and stress response in Arabidopsis

2019 ◽  
Author(s):  
Olga Kirioukhova-Johnston ◽  
Pallavi Pawar ◽  
Geetha Govind ◽  
Pramod Pantha ◽  
René Lemcke ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Cell Differentiation ◽  
Stress Response ◽  
Eukaryotic Cell ◽  
Cell Development ◽  
Egg Cell ◽  
Transcription Factor Network ◽  
Sexual And Asexual Reproduction ◽  
Myb Proteins

AbstractThe multicellular embryo, and ultimately the entire organism, is a derivative of the fertilized egg cell. Unlike in animals, transcription factor networks orchestrating faithful egg development are still largely unknown in plants. We have identified that egg cell differentiation in Arabidopsis require interplay between evolutionarily conserved onco-protein homologs RETINOBLASTOMA-RELATED (RBR) and redundant MYB proteins MYB64/MYB119. RBR physically interacts with the MYBs; and with plant-specific transcription factors belonging to the RWP-RK-domain (RKD) family and LEAFY COTYLEDON1 (LEC1), which participate in development of egg cells and inherent stress response. RBR binds to most of these egg cell-expressed loci at the DNA level, partially overlapping with sites of histone methylation H3K27me3. Since deregulation of RKDs phenocopies mutants of RBR and the MYBs in terms of cell proliferation in the egg cell spatial domain, all the corresponding proteins are likely required to restrict parthenogenetic cell divisions of the egg cells. Cross-talk among these transcription factors, and direct regulation by RBR, govern egg cell development and expression of egg-to-zygotic polarity factors of the WUSCHEL RELATED HOMEOBOX family. Together, a network of RBR-centric transcription factors underlies egg cell development and stress response, possibly, in combination with several other predicted nodes.Author summaryThe RETINOBLASTOMA protein is one of the core components of the Eukaryotic cell cycle, and corresponding evolutionary homologs have been implicated not only to repress cell division but also to control differentiation and development. How RETINOBLASTOMA RELATED (RBR) associate with other higher order regulators to control faithful egg cell development in sexual plants is pivotal for manipulation of successful reproduction in general, and engineering of parthenogenesis when asexual or apomictic seed progeny are desirable over sexual plants. Using a suite of molecular methods, we show that a RBR-associated transcription factor network operates to specify egg cells in Arabidopsis. Complex cross-regulation within these transcription factors seems to be necessary for successful maternal egg cell to zygotic transition and reproductive stress response. Detailed genetic analysis implicate that RBR and its interactive partners belonging to MYB and RWP-RK transcription factor families are possibly required to prevent parthenogenesis of the sexual egg cells. Novel RBR networks and stress nodes explained in this study might help to improve our understanding of sexual and asexual reproduction.

scholarly journals IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF

2005 ◽  
Vol 201 (8) ◽  
pp. 1197-1203 ◽  
Author(s):  
Kazu Kikuchi ◽  
Anne Y. Lai ◽  
Chia-Lin Hsu ◽  
Motonari Kondo
Keyword(s):  
Transcription Factor ◽  
B Cells ◽  
B Cell ◽  
Target Genes ◽  
Cell Development ◽  
B Cell Development ◽  
Receptor Signaling ◽  
Cell Stage ◽  
Transcription Factor Network ◽  
Stage Transition

Cytokine receptor signals have been suggested to stimulate cell differentiation during hemato/lymphopoiesis. Such action, however, has not been clearly demonstrated. Here, we show that adult B cell development in IL-7−/− and IL-7Rα2/− mice is arrested at the pre–pro-B cell stage due to insufficient expression of the B cell–specific transcription factor EBF and its target genes, which form a transcription factor network in determining B lineage specification. EBF expression is restored in IL-7−/− pre–pro-B cells upon IL-7 stimulation or in IL-7Rα−/− pre–pro-B cells by activation of STAT5, a major signaling molecule downstream of the IL-7R signaling pathway. Furthermore, enforced EBF expression partially rescues B cell development in IL-7Rα−/− mice. Thus, IL-7 receptor signaling is a participant in the formation of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage transition from the pre–pro-B to further maturational stages.

scholarly journals Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Immunity ◽  
2020 ◽  
Vol 53 (2) ◽  
pp. 353-370.e8 ◽  
Author(s):  
Urszula Cytlak ◽  
Anastasia Resteu ◽  
Sarah Pagan ◽  
Kile Green ◽  
Paul Milne ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dendritic Cell ◽  
Cell Development

scholarly journals The Signal Transducer STAT5 Inhibits Plasmacytoid Dendritic Cell Development by Suppressing Transcription Factor IRF8

Immunity ◽  
2008 ◽  
Vol 28 (4) ◽  
pp. 509-520 ◽  
Author(s):  
Eiji Esashi ◽  
Yui-Hsi Wang ◽  
Olivia Perng ◽  
Xiao-Feng Qin ◽  
Yong-Jun Liu ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Cell Development ◽  
Signal Transducer

scholarly journals Transcription factor networks in dendritic cell development

2011 ◽  
Vol 23 (5) ◽  
pp. 388-397 ◽  
Author(s):  
Ansuman T. Satpathy ◽  
Kenneth M. Murphy ◽  
Wumesh KC
Keyword(s):  
Transcription Factor ◽  
Dendritic Cell ◽  
Cell Development ◽  
Transcription Factor Networks

Enhancer landscape dynamics during monocyte and dendritic cell development and the role of the transcription factor IRF8

2015 ◽  
Vol 43 (9) ◽  
pp. S98
Author(s):  
Daisuke Kurotaki ◽  
Jun Nakabayashi ◽  
Akira Nishiyama ◽  
Haruka Sasaki ◽  
Naofumi Kaneko ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dendritic Cell ◽  
Cell Development ◽  
Landscape Dynamics

scholarly journals Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells

Blood ◽  
2011 ◽  
Vol 117 (6) ◽  
pp. 1880-1887 ◽  
Author(s):  
Hak-Jong Choi ◽  
Yanbiao Geng ◽  
Hoonsik Cho ◽  
Sha Li ◽  
Pramod Kumar Giri ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Nk Cells ◽  
Nk Cell ◽  
Nkt Cells ◽  
Cell Development ◽  
Intrinsic Defect ◽  
Nkt Cell ◽  
Ets Family ◽  
And Function

Abstract E26 Transformation specific (Ets) family transcription factors control the expression of a large number of genes regulating hematopoietic cell development and function. Two such transcription factors, Ets-1 and myeloid Elf-1–like factor (MEF), have been shown to play critical roles in both natural killer (NK)– and NKT-cell development, but not in the development of conventional T cells. In this study, we address the role of E74-like factor 1 (Elf-1), another Ets family transcription factor that is closely related to MEF but divergent from Ets-1, in NK- and NKT-cell development using Elf-1–deficient (Elf-1−/−) mice. Whereas the proportion of NK cells in Elf-1−/− mice was normal, the proportion of NKT cells was significantly reduced in the thymus and periphery of Elf-1−/− mice compared with wild-type (WT) mice. Although Ets-1–deficient mice lack NKT cells altogether, Elf-1−/− mice exhibited only a partial block in NKT-cell development caused by a cell-intrinsic defect in the selection, survival, and maturation of NKT cells. In addition, residual NKT cells found in Elf-1−/− mice produced less cytokine upon antigen stimulation compared with WT NKT cells. Our data demonstrate that Elf-1 plays an important and nonredundant role in the development and function of NKT cells, but is not involved in NK-cell development.

scholarly journals Regulatory Non-Coding RNAs Modulate Transcriptional Activation During B Cell Development

2021 ◽  
Vol 12 ◽  
Author(s):  
Mary Attaway ◽  
Tzippora Chwat-Edelstein ◽  
Bao Q. Vuong
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
B Cell ◽  
Transcriptional Activation ◽  
Subsequent Development ◽  
Cell Development ◽  
B Cell Development ◽  
Hematopoietic Stem ◽  
Cell Fate Decisions ◽  
Non Coding Rnas

B cells play a significant role in the adaptive immune response by secreting immunoglobulins that can recognize and neutralize foreign antigens. They develop from hematopoietic stem cells, which also give rise to other types of blood cells, such as monocytes, neutrophils, and T cells, wherein specific transcriptional programs define the commitment and subsequent development of these different cell lineages. A number of transcription factors, such as PU.1, E2A, Pax5, and FOXO1, drive B cell development. Mounting evidence demonstrates that non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), modulate the expression of these transcription factors directly by binding to the mRNA coding for the transcription factor or indirectly by modifying cellular pathways that promote expression of the transcription factor. Conversely, these transcription factors upregulate expression of some miRNAs and lncRNAs to determine cell fate decisions. These studies underscore the complex gene regulatory networks that control B cell development during hematopoiesis and identify new regulatory RNAs that require additional investigation. In this review, we highlight miRNAs and lncRNAs that modulate the expression and activity of transcriptional regulators of B lymphopoiesis and how they mediate this regulation.

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