Causal mediation analysis of the relationship of canakinumab's effect against subsequent gout flares and high‐sensitivity C‐reactive protein in CANTOS

2021 ◽  
Author(s):  
Kazuki Yoshida ◽  
Robert J. Glynn ◽  
Hyon K. Choi ◽  
Brendan M. Everett ◽  
Yi Li ◽  
...  
Keyword(s):  
Mediation Analysis ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Causal Mediation ◽  
Causal Mediation Analysis ◽  
Relationship Of ◽  
The Relationship ◽  
Gout Flares

scholarly journals Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Sameer Shaharyar ◽  
Lara L. Roberson ◽  
Omar Jamal ◽  
Adnan Younus ◽  
Michael J. Blaha ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
High Sensitivity ◽  
Abdominal Ultrasound ◽  
Normal Weight ◽  
C Reactive Protein ◽  
Cvd Risk ◽  
Reactive Protein ◽  
Metabolically Healthy Obese ◽  
Metabolically Healthy ◽  
Relationship Of

Background. Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes. The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities.Methods. We evaluated 5,519 healthy, Brazilian subjects (43±10years, 78% males), free of known cardiovascular disease. Those with <2 metabolic risk factors (MRF) were considered metabolically healthy, and those with BMI ≥ 25 kg/m2and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW). High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound.Results. Overall, 40% of OW individuals were metabolically healthy, and 12% normal-weight had ≥2 MRF. The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22% versus 12%, and 40% versus 8% respectively (P<0.001). Both MHO individuals and metabolically unhealthy normal weight (MUNW) phenotypes were associated with elevated hsCRP and HS.Conclusion. Our study suggests that MHO and MUNW phenotypes may not be benign and physicians should strive to treat individuals in these subgroups to reverse these conditions.

scholarly journals A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sarah Tan Siyin ◽  
Tong Liu ◽  
Wenqiang Li ◽  
Nan Yao ◽  
Guoshuai Xu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Regression Models ◽  
Primary Liver Cancer ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
The Relationship ◽  
New Onset

Abstract Background Competing risk method has not been used in a large-scale prospective study to investigate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) elevate the risk of primary liver cancer (PLC). Our study aims to prospectively investigate the relationship between hs-CRP and new-onset PLC. Methods and results Ninety-five thousand seven hundred fifty-nine participants without the diagnosis of PLC, and who had their demographic characteristics and biochemical parameters recorded, were analyzed from the Kailuan Cohort study. Cox proportional hazards regression models and competing risk regression models were used to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of PLC. During a median follow-up of 11.07 years, 357 incidental PLC cases were identified over a total of 1,035,039 person-years. The multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.07(0.82 ~ 1.38), 1.51(1.15 ~ 1.98) in a Cox proportional hazard regression analysis adjusted for other potential confounders. In the cause-specific hazard model, the multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.06(0.81 ~ 1.40), 1.50(1.14 ~ 1.99). Similar results were also observed in the sub-distribution hazard function model with corresponding multivariate HRs (95%CI) of 1.05(0.80 ~ 1.40), 1.49(1.13 ~ 1.98) in hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L group, respectively. Conclusions This prospective study found a significant association of higher levels of hs-CRP with new-onset PLC. The main clinical implications would be an increased awareness of hs-CRP and its correlation to the risk of PLC. This study should be a steppingstone to further research on chronic inflammation and PLC. Trial registration Registration number:ChiCTR–TNRC–11001489.

scholarly journals Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Dan Jin ◽  
Dao-Min Zhu ◽  
Hong-Lin Hu ◽  
Meng-Nan Yao ◽  
Wan-Jun Yin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lipid Profile ◽  
High Sensitivity ◽  
Vitamin D Status ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship
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